Vitamin D, Race, and Excessive Daytime Sleepiness

McCarty, David E.; Reddy, Aronkumar; Keigley, Quinton; Kim, Paul Y.; Marino, Andrew A.

doi:10.5664/jcsm.2266

Cited by 101 publications

(81 citation statements)

References 27 publications

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“…It is clear that there is a link between lipids, such as polyunsaturated fatty acids, cholesterol or vitamin D and various neuropsychiatric diseases. For example, vitamin D deficiency can impact mental health in various ways: as relevant for depression, it can cause seasonal affective disorders (discomfort, depression, fatigue); is relevant to schizophrenia and autism, as the foetal brain develops vitamin D deficiency may cause permanent brain function impairment [119]; it leads to sleep disorders [120]. It is also hypothesised that vitamin D deficiency in adults may lead to parental germ cell degradation, causing autistic disorders.…”

Section: Discussionmentioning

confidence: 99%

Application of fatty acid and lipid measurements in neuropsychiatry

Grela

Rachel

Cole

et al. 2016

Clinical Chemistry and Laboratory Medicine (CCLM)

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Abstract:The importance of lipids in the understanding of disease states is constantly increasing. Whilst the link between metabolic disorders and lipids seems to be clear, interpreting lipid regulation in the context of neuropsychiatric disorders is a new approach. Mental disorders account for almost 15% of the total global disease burden with Alzheimer's disease, depression or schizophrenia being amongst the most widespread mental disorders in the general population. For this reason rapid and early diagnosis is crucial and finding the right biomarkers is of great importance. Lipids appear to be essential in learning the aetiopathology of neuropsychiatric diseases as well as in biomarker research as they are most abundantly present in the brain. This study discusses recent findings in neuropsychiatry in the context of lipid analysis.

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Section: Discussionmentioning

confidence: 99%

Application of fatty acid and lipid measurements in neuropsychiatry

Grela

Rachel

Cole

et al. 2016

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…1 about our recent publication, 2 that a relationship between the Epworth Sleepiness Scale score (ESSs) and circulating 25-OH Vitamin D is interesting, but disagree that the research as presented was confusing. Instead, we would suggest a more accurate assessment is that the identifi ed relationships are complex and requiring of further study.…”

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confidence: 99%

We've Only Just Begun: A Conversation Started Shouldn't Be Mistaken for The Last Word

McCarty

Marino

2013

Journal of Clinical Sleep Medicine

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1 about our recent publication, 2 that a relationship between the Epworth Sleepiness Scale score (ESSs) and circulating 25-OH Vitamin D is interesting, but disagree that the research as presented was confusing. Instead, we would suggest a more accurate assessment is that the identifi ed relationships are complex and requiring of further study. These points were stated fairly clearly in the discussion.To be included in this cohort, subjects merely had to admit to the presence of moderate or severe musculoskeletal pain either interfering with sleep or interfering with daytime function. Dr. Ganguly raises the point that one would expect "insomnia secondary to medical condition" to be the most prevalent sleep disorder, whereas insomnia was only reported in 16% of our sample. In response to this, we can only state that, according to the judgment of the physician caring for the patient (DM), the most appropriate clinical diagnoses were given at the time of the encounter, and these diagnoses were abstracted and reported during the process of research-related chart review. These data were provided merely to provide some degree of background information to clinicians who wish to see if the population we studied was at all comparative to clinical populations they serve. The fact that the data don't adhere to Dr. Ganguly's expectations is noted, but is also arguably irrelevant to the major fi ndings presented.Next, Dr. Ganguly raises multiple questions about the underlying mechanism of EDS within the cohort we studied, stating that EDS may be related to each subject's underlying sleep disorders, tendency toward noncompliance, whether melanin may somehow be involved, and so forth. The issue of causation was clearly addressed in the discussion section of the paper-an association between two variables does not guarantee causation. It is crucial to emphasize, how- ever, that this study was never designed to provide conclusive data on causation. To this point, we gently remind Dr. Ganguly that causation cannot be investigated at all if an association is not recognized to exist. We hope this paper helps initiate the scientifi c conversation about the possible role of Vitamin D defi ciency in the pathophysiology of sleep disorders, as well as the potential role of Vitamin D supplementation in the treatment and/ or prevention of diseases encountered by Sleep Medicine specialists. We agree with Dr. Ganguly that more research is needed to help resolve these unanswered questions. CITATIONMcCarty DE; Marino AA. We've only just begun: a conversation started shouldn't be mistaken for the last word. J Clin Sleep Med 2013;9(5):519. REFERENCES1. Ganguly G. Vitamin D defi ciency, excessive daytime sleepiness:an epiphenomenon or a "chicken or an egg-which came fi rst" issue?

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“…T he new research by McCarty et al 1 titled "Vitamin D, Race, and Excessive Daytime Sleepiness" was very interesting as well as somewhat confusing. The authors reported that more than half of their patients with somatic pain and sleep disruption had vitamin D defi ciency.…”

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confidence: 99%