Vitamin D Stored in Fat Tissue During a 5-Year Intervention Affects Serum 25-Hydroxyvitamin D Levels the Following Year

Martinaityte, Ieva; Kamycheva, Elena; Didriksen, Allan; Jakobsen, Jette; Jorde, Rolf

doi:10.1210/jc.2017-01187

Cited by 61 publications

(53 citation statements)

References 26 publications

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“…There was a negative trend in serum 25(OH)D concentrations that was fastest in the first 3 months and yielded a half-life of 83 days. The half-life of serum 25(OH)D thereafter was 255 days, indicating a much slower decrease of 25(OH)D after the first 3 months (27). A similar pattern of elimination was demonstrated in our dog where serum 25(OH)D concentrations substantially decreased in the first 4 months and then proceeded to gradually decrease thereafter.…”

Section: Discussionsupporting

confidence: 85%

“…However, even this tightly regulated negative feedback system can be circumvented by markedly increased 25(OH)D concentrations, which can activate vitamin D receptors as well as displace calcitriol from its carrier protein resulting in excessive "free" calcitriol concentrations (24)(25)(26). The reported half-life of serum 25(OH)D following cholecalciferol rodenticide toxicosis is variable and likely longer than reported in the veterinary literature, as demonstrated by a recent human study that examined vitamin D storage following administration of oral cholecalciferol for 5 years (27). Interestingly, that study identified that the serum half-life of 25(OH)D and thus rate of elimination varied with time.…”

Section: Discussionmentioning

confidence: 99%

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Persistent Increase in Serum 25-Hydroxyvitamin D Concentration in a Dog Following Cholecalciferol Intoxication

Gerhard

Jaffey

2020

Front. Vet. Sci.

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Cholecalciferol is becoming an increasingly utilized rodenticide in the United States due to changes implemented by the Environmental Protection Agency (EPA) to reduce unintended exposure of wildlife to second-generation anticoagulant rodenticides. The lipophilic properties of cholecalciferol and prolonged tissue elimination are well-documented; however, long-term clinical ramifications are unknown. This report describes unique clinicopathologic and treatment features during the acute phase of cholecalciferol rodenticide toxicosis in a 4-year-old neutered Shih-Tzu mix that presented for intermittent vomiting, anorexia, polyuria, and polydipsia. In addition, this report also highlights the potential benefit of serial measurements of serum 25-hydroxyvitamin D concentrations and long-term treatment in the chronic phase of cholecalciferol rodenticide toxicosis in dogs.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Persistent Increase in Serum 25-Hydroxyvitamin D Concentration in a Dog Following Cholecalciferol Intoxication

Gerhard

Jaffey

2020

Front. Vet. Sci.

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“…The amount of time spent in the sun shown to be beneficial may be such that sufficient amounts of vitamin D are created for storage and release during the winter, when temperatures and low UVB radiation availability make vitamin D production impossible-such as at northern latitudes. Previous research has shown vitamin D produced as a result of solar UVR exposure can be stored in adipose tissue and released during times of vitamin D insufficiency (Martinaityte et al 2017). The lack of a greater protective effect with higher sun exposure may also be influenced by a sublinear relationship between sun exposure and dermal synthesis of vitamin D (Nair-Shalliker et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Solar Ultraviolet Radiation and Breast Cancer Risk: A Systematic Review and Meta-Analysis

O’Sullivan

Brenner

et al. 2020

Environ Health Perspect

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BACKGROUND: A protective relationship has been hypothesized between exposure to solar ultraviolet radiation (UVR) and the development of breast cancer. OBJECTIVE: The objective of this study was to conduct a systematic literature review and meta-analysis of studies examining the association of exposure to solar UVR and breast cancer risk. METHODS: We searched Medline, EMBASE, and Web of Science for all studies investigating exposure to solar UVR and breast cancer risk. Separate analyses were performed using estimates of time spent in the sun, and ambient UVR. Associations were estimated using DerSimonian and Laird random-effect models. Heterogeneity was investigated through subgroup analyses and I 2 statistics. RESULTS: Fourteen studies were included in the review and 13 in the meta-analysis, with the majority (n = 8) conducted in North America. We observed a decreased risk of breast cancer for individuals spending ≥1 h=d in the sun during summer months over a lifetime or usual adulthood compared with <1 h=d [pooled relative risk ðRRÞ = 0:84; 95% CI: 0.77, 0.91]. Spending ≥2 h=d in the sun had a similar protective effect as 1 to <2 h=d when compared with <1 h=d (RR = 0.83; 95% CI: 0.75, 0.93 vs. 0.83; 95% CI: 0.78, 0.89). Exposure during adolescence was suggestive of a lower risk of breast cancer than exposure later in life (≥45 years of age) (RR = 0.83; 95% CI: 0.71, 0.98 vs. 0.97; 95% CI: 0.85, 1.11). Ambient UVR was not associated with the risk of breast cancer (RR = 1.00; 95% CI: 0.93, 1.09). DISCUSSION: To our knowledge, this was the first meta-analysis to estimate the risk of developing breast cancer associated with time spent in the sun. The results suggest that obtaining greater than an hour a day in the sun during the summer months could decrease the risk of developing breast cancer.

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“…Supplementing with 20 000 international units (IU) of vitamin D 3 per week for 3-5 years leads to a substantial increase in vitamin D 3 content in subcutaneous abdominal adipose tissue, approximately sixfold greater than placebo (Didriksen et al 2015). The amount of 25(OH)D present in adipose explants remained correlated with serum 25(OH)D concentrations 1 year after supplementation had ceased (Martinaityte et al 2017). Although it is worth noting that values for serum 25(OH)D and adipose tissue vitamin D 3 measured in this study varied considerably between participants, which may be explained by the fourfold variation in body fat mass across the study population.…”

Section: Vitamin D Accumulation In Adiposementioning

confidence: 99%

Mobilising vitamin D from adipose tissue: The potential impact of exercise

et al. 2019

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Vitamin D is lipophilic and accumulates substantially in adipose tissue. Even without supplementation, the amount of vitamin D in the adipose of a typical adult is equivalent to several months of the daily reference nutrient intake (RNI). Paradoxically, despite the large amounts of vitamin D located in adipose tissue, individuals with obesity are often vitamin D deficient according to consensus measures of vitamin D status (serum 25‐hydroxyvitamin D concentrations). Thus, it appears that vitamin D can become ‘trapped’ in adipose tissue, potentially due to insufficient lipolytic stimulation and/or due to tissue dysfunction/adaptation resulting from adipose expansion. Emerging evidence suggests that exercise may mobilise vitamin D from adipose (even in the absence of weight loss). If exercise helps to mobilise vitamin D from adipose tissue, then this could have important ramifications for practitioners and policymakers regarding the management of low circulating levels of vitamin D, as well as chronically low levels of physical activity, obesity and associated health conditions. This perspective led us to design a study to examine the impact of exercise on vitamin D status, vitamin D turnover and adipose tissue vitamin D content (the VitaDEx project). The VitaDEx project will determine whether increasing physical activity (via exercise) represents a potentially useful strategy to mobilise vitamin D from adipose tissue.

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Vitamin D Stored in Fat Tissue During a 5-Year Intervention Affects Serum 25-Hydroxyvitamin D Levels the Following Year

Abstract: Vitamin D and 25(OH)D stored in adipose tissue after 3 to 5 years of vitamin D supplementation may have a clinically relevant effect on serum 25(OH)D level the following year.

Cited by 61 publications

References 26 publications

Persistent Increase in Serum 25-Hydroxyvitamin D Concentration in a Dog Following Cholecalciferol Intoxication

Persistent Increase in Serum 25-Hydroxyvitamin D Concentration in a Dog Following Cholecalciferol Intoxication

Solar Ultraviolet Radiation and Breast Cancer Risk: A Systematic Review and Meta-Analysis

Mobilising vitamin D from adipose tissue: The potential impact of exercise

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