Vitamin D supplementation to improve pregnancy and perinatal outcomes: an overview of 42 systematic reviews

Bialy, Liza; Fenton, Tanis R.; Shulhan-Kilroy, Jocelyn; Johnson, David W.; McNeil, Deborah; Hartling, Lisa

doi:10.1136/bmjopen-2019-032626

Cited by 39 publications

(27 citation statements)

References 40 publications

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“…Thus, there is some evidence from observational studies about the associations between vitamin D serum levels and maternal outcomes, such as GDM development; however, an overview of several systematic reviews, examining effectiveness from RCTs on 25(OH)D supplementation, showed no effect in pregnancy (136).…”

Section: Nutritional Requirements and Role Of Nutraceuticals In Gdmmentioning

confidence: 99%

Nutrition and Metabolic Adaptations in Physiological and Complicated Pregnancy: Focus on Obesity and Gestational Diabetes

Parrettini

Caroli

Torlone³

2020

Front. Endocrinol.

164

108

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Pregnancy offers a window of opportunity to program the future health of both mothers and offspring. During gestation, women experience a series of physical and metabolic modifications and adaptations, which aim to protect the fetus development and are closely related to both pre-gestational nutritional status and gestational weight gain. Moreover, pre-gestational obesity represents a challenge of treatment, and nowadays there are new evidence as regard its management, especially the adequate weight gain. Recent evidence has highlighted the determinant role of nutritional status and maternal diet on both pregnancy outcomes and long-term risk of chronic diseases, through a transgenerational flow, conceptualized by the Development Origin of Health and Diseases (Dohad) theory. In this review we will analyse the physiological and endocrine adaptation in pregnancy, and the metabolic complications, thus the focal points for nutritional and therapeutic strategies that we must early implement, virtually before conception, to safeguard the health of both mother and progeny. We will summarize the current nutritional recommendations and the use of nutraceuticals in pregnancy, with a focus on the management of pregnancy complicated by obesity and hyperglycemia, assessing the most recent evidence about the effects of ante-natal nutrition on the long-term, on either maternal health or metabolic risk of the offspring.

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Section: Nutritional Requirements and Role Of Nutraceuticals In Gdmmentioning

confidence: 99%

Nutrition and Metabolic Adaptations in Physiological and Complicated Pregnancy: Focus on Obesity and Gestational Diabetes

Parrettini

Caroli

Torlone³

2020

Front. Endocrinol.

164

108

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“…In this review, we focus on UFs and vitamin D, and not pregnancy. We included references for readers interested in the relationship between vitamin D, reproduction, and pregnancy [16,[76][77][78].…”

Section: Vitamin D and Uterine Fibroids-perinatal Implicationsmentioning

confidence: 99%

The Significance of Measuring Vitamin D Serum Levels in Women with Uterine Fibroids

et al. 2020

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Uterine fibroids (UFs) are benign tumors originating from smooth muscle cells and are considered a common pathology that affects numerous women which is a notable socio-economic problem. Several UF risk factors have been identified including black race, obesity, and vitamin D deficiency. Vitamin D is steroid compound with pleiotropic effects on the human body. Vitamin D deficiency is a major public health concern worldwide. Several studies have shown that the majority of UF patients experienced hypovitaminosis D. In addition, sufficient vitamin D serum levels are associated with the reduced risk of UFs. In this review, we present available data highlighting the importance of measuring vitamin D serum levels in women with UFs and women at a high risk for UF development. We proposed a preliminary clinical instruction of 25-hydroxyvitamin D measurements and vitamin D supplementation for clinicians who are involved in the treatment of patients with UFs. Achieving sufficient serum levels of vitamin D might be of interest in patients with UFs. Screening, supplementation, treatment guidelines, and public health strategies for vitamin D deficiency in women with UFs as well as women at a high risk of UF development might be of potential importance as well.

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“…Similar findings have been reported in an umbrella review of meta-analyses of observational studies (16) . However, in an overview of forty-two systematic reviews, mixed results were presented for the associations between maternal vitamin D and LBW (17) . Current literature relating maternal vitamin D to birth weight is inconclusive.…”

mentioning

confidence: 99%

The association between maternal fat-soluble vitamin concentrations during pregnancy and infant birth weight in China

Yang

Jiao

et al. 2020

Br J Nutr

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Fat-soluble vitamins during pregnancy are of vital importance for fetal growth and development. The present study aimed at exploring the association between vitamin A, E and D status during pregnancy and birth weight. A total of 19,640 women with singleton deliveries from a retrospective study were included. Data were collected by the hospital electronic information system. Maternal serum vitamin A, E and D concentrations were measured during pregnancy. Logistic regression was performed to estimate the association between the vitamins status and low birth weight (LBW) or macrosomia. Women with excessive vitamin E were more likely to have macrosomia (OR: 1.30, 95% CI: 1.07-1.59) compared with adequate concentration. When focusing on Z scores, there was a positive association between vitamin E and macrosomia in the 1st (OR: 1.07, 95% CI: 1.00-1.14), 2nd (OR: 1.27, 95% CI: 1.11-1.46) and 3rd (OR: 1.28, 95% CI: 1.06-1.54) trimesters; vitamin A was positively associated with LBW in the 1st (OR: 1.14, 95% CI: 1.01-1.29), 2nd (OR: 1.31, 95% CI: 1.05-1.63) and 3rd (OR: 2.00, 95% CI: 1.45-2.74) trimesters, and negatively associated with macrosomia in the 2nd (OR: 0.79, 95% CI: 0.70-0.89) and 3rd (OR: 0.77, 95% CI: 0.62-0.95) trimesters. The study identified that high concentrations of vitamin E are associated with macrosomia. Maintaining a moderate concentration of vitamin A during pregnancy might be beneficial to achieve optimal birth weight. Further studies to explore the mechanism of associations above are warranted.

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Vitamin D supplementation to improve pregnancy and perinatal outcomes: an overview of 42 systematic reviews

Cited by 39 publications

References 40 publications

Nutrition and Metabolic Adaptations in Physiological and Complicated Pregnancy: Focus on Obesity and Gestational Diabetes

Nutrition and Metabolic Adaptations in Physiological and Complicated Pregnancy: Focus on Obesity and Gestational Diabetes

The Significance of Measuring Vitamin D Serum Levels in Women with Uterine Fibroids

The association between maternal fat-soluble vitamin concentrations during pregnancy and infant birth weight in China

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