Vitamin E and Immune Response in the Aged

Meydani, Simin Nikbin; Beharka, A.A.

doi:10.1159/000059469

Cited by 13 publications

(16 citation statements)

References 34 publications

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“…Elevated PGE2 concentration has been associated in the elderly with unfavorable effects on the immune system. 30 Our results reinforce previous findings on the potential benefit to the immune system of increasing vit-E intake. Serum levels of cytokines (TNF-␣ and IL-1␤) were lower among stroke patients (6.0Ϯ0.4 and 0.5Ϯ0.05 pg/mL, respectively) than among controls (7.0Ϯ0.2 and 1.5Ϯ0.3 pg/mL; Table 2), perhaps because the blood was collected 48 to 120 hours after stroke.…”

Section: Resultssupporting

confidence: 91%

Decreased Levels of Plasma Vitamin C and Increased Concentrations of Inflammatory and Oxidative Stress Markers After Stroke

Sánchez‐Moreno

Dashe

Scott

et al. 2004

Stroke

170

108

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Background and Purpose-Inflammatory response is a critical component of the complex pathophysiological response to stroke. Vitamin C has been shown to have important roles in cell performance and vascular function. In this study, we compared the nutritional status and levels of inflammatory markers between stroke cases and controls and assessed which antioxidant was associated with levels of inflammatory markers and oxidative stress among cases and controls. Methods-We evaluated the nutritional status and measured plasma levels of vitamins C and E, uric acid, serum levels of C-reactive protein (CRP), the cytokines tumor necrosis factor-␣ and interleukin-1␤, intercellular adhesion molecule-1 (ICAM-1) and chemokine monocyte chemoattractant protein-1 (MCP-1), prostaglandins PGE2 and PGI2, and 8-isoprostanes (8-epiPGF 2␣ ) for 15 patients with ischemic stroke within 2 to 5 days after stroke onset and for 24 control subjects. Results-Stroke patients had significantly lower plasma levels of vitamin C than did controls. Among stroke patients, CRP was significantly elevated, as were the ICAM-1, MCP-1, and 8-epiPGF 2␣ , but the prostaglandins PGE2 and PGI2 were significantly reduced. Interestingly, vitamin C concentration was significantly inversely correlated with the levels of CRP and 8-epiPGF 2␣ among stroke patients, and 8-epiPGF 2␣ was significantly associated with the levels of CRP. Uric acid was also elevated among stroke patients. Conclusions-Lower

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Section: Resultssupporting

confidence: 91%

Decreased Levels of Plasma Vitamin C and Increased Concentrations of Inflammatory and Oxidative Stress Markers After Stroke

Sánchez‐Moreno

Dashe

Scott

et al. 2004

Stroke

170

108

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“…Dietary vitamin E supplementation increased IgM and interleukin production by bovine peripheral mononuclear cells (Stabel et al, 1992) and also modulated prostaglandin release from activated macrophages during infections (Likoff et al, 1981). Prostaglandins inhibit the functional activity of lymphocytes and macrophages by decreasing the susceptibility of cells to mitogen stimulation and subsequent cellular differentiation (Meydani and Hafek, 1992). Zinc supplementation enhances cow's immunity by increasing resistance to infections and by decreasing severity of infection (Goff and Stabel, 1990;Campbell and Miller, 1998).…”

Section: Introductionmentioning

confidence: 99%

Effect of additional vitaminEand zinc supplementation on immunological changes in peripartumSahiwal cows

Chandra

Aggarwal

Kumar

et al. 2014

Animal Physiology Nutrition

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This study was conducted to exploit ameliorative effect of additional vitamin E and/or zinc supplementation on immune response of peripartum Sahiwal cows. Thirty-two pregnant dry Sahiwal cows were blocked into four treatment groups (n = 8), namely control, zinc (Zn), vitamin E (Vit E) and zinc + vitamin E (Zn + Vit E). Feeding regimen was same in all the groups except that the Sahiwal cows in the zinc-, vitamin E- and zinc + vitamin E-fed groups were additionally supplemented with 60 mg Zn/kg DM, 1000 IU vitamin E and 60 mg/kg + 1000 IU Zn + vitamin E, respectively, from day 60 pre-partum to day 90 post-partum. Blood samples were collected on days -60, -45, -30, -15, -7, -3, 0, 3, 7, 15, 30, 45, 60, 90 and 120 with respect to day of parturition and analysed for total immunoglobulin (TIG), immunoglobulin G (IgG), interleukin-2 (IL-2), vitamin E (Vit E) and zinc (Zn) status. Before calving, cows showed a decrease in plasma TIG, IgG, IL-2, Vit E and Zn levels. However, increased levels of plasma TIG, IgG, IL-2, Vit E and Zn were observed after calving. After calving, Sahiwal cows supplemented with Zn + Vit E had higher plasma TIG, IgG and IL-2 in comparison with cows of control and Zn + Vit E-fed groups. In the present study, plasma vitamin E level was higher in Vit E-fed and Zn + Vit E-fed cows; however, zinc level was higher in Zn- and Zn + Vit E-supplemented cows. In conclusion, a reduced immune response during peripartum period in Sahiwal cows was ameliorated by dietary vitamin E and zinc supplementation.

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“…Vitamin E supplementation at higher than recommended levels has been shown to enhance cellular (Cipriano et al, 1982) and humoral immune response (Samanta et al, 2006) in calves. More importantly, supplementation of vitamin E at higher levels than those currently recommended appears to be safe (Bendich and Machlin, 1988;Meydani and Hafek, 1992;Bendich, 1993). Looking into all these aspects, NRC (2001) has increased the vitamin E requirement of calves by 25 per cent, i.e.…”

Section: Introductionmentioning

confidence: 99%

Effect of vitamin E supplementation on serum alpha tocopherol and immune status of Murrah buffalo (<i>Bubalus bubalis</i>) calves

Rajeesh¹,

Dass²,

Garg³

et al. 2008

J. Anim. Feed Sci.

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The study evaluated the effect of graded levels of vitamin E supplementation on the serum α-tocopherol, retinol concentrations and immune response of buffalo calves. In a completely randomized design, 15 male Murrah buffalo calves (14-15 months old; 194.0 ± 3.5 kg average body weight) were divided into 3 equal groups on the basis of their body weights. All the calves were fed on wheat straw and concentrate mixture to meet their nutrients requirements. In addition, all the calves in group II and III were supplemented with 300 and 600 IU of feed grade DL-α-tocopheryl acetate/d, respectively. Blood samples were collected at zero day and subsequently at 30 days intervals up to 120 days to estimate serum α-tocopherol and retinol concentration. To assess humoral immune response, all the buffalo calves were sensitized with formalin inactivated Pasteurella multocida antigen and blood was collected on 0, 7, 14, 21 and 28 days post vaccination to study antibody production using indirect ELISA, whereas cell mediated immune response of buffalo calves was assessed by in vivo delayed type hypersensitivity (DTH) reaction against phytohaemaglutinin-P (PHA-P).Retinol concentration (µg/ml) in blood serum of three groups of calves was statistically similar (P>0.05), whereas the cumulative group mean serum α-tocopherol concentration (µg/dl) was significantly (P<0.01) higher in vitamin E supplemented groups as compared to control group. The pooled mean ELISA antibody titer against Pasteurella multocida was also signifi cantly (P<0.05) higher in buffalo calves given vitamin E as compared to control group calves, but cell mediated immune response was similar ((P>0.05) in three groups. Results of the present study indicated that vitamin E

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Vitamin E and Immune Response in the Aged

Cited by 13 publications

References 34 publications

Decreased Levels of Plasma Vitamin C and Increased Concentrations of Inflammatory and Oxidative Stress Markers After Stroke

Decreased Levels of Plasma Vitamin C and Increased Concentrations of Inflammatory and Oxidative Stress Markers After Stroke

Effect of additional vitaminEand zinc supplementation on immunological changes in peripartumSahiwal cows

Effect of vitamin E supplementation on serum alpha tocopherol and immune status of Murrah buffalo (<i>Bubalus bubalis</i>) calves

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