Vitamin E pretreated Wharton’s jelly-derived mesenchymal stem cells attenuate CCl4-induced hepatocyte injury in vitro and liver fibrosis in vivo

Baig, Maria Tayyab; Ghufran, Hafiz; Mehmood, Azra; Azam, Maryam; Humayun, Shamsa; Riazuddin, Sheikh

doi:10.1016/j.bcp.2021.114480

Cited by 16 publications

(12 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Coculturing BMSCs with hepatocyte growth factor (HGF) and murine fetal liver cells on laminin-coated dishes could remarkably differentiate them into hepatic-like cells expressing ALB, AFP, and CK-19 [ 13 ]. Coculturing injured hepatocytes with WJMSCs pretreated with Vitamin E reduce hepatic markers such as ALT, and mRNA level of other factors include IL-1 β [ 14 ].…”

Section: Resultsmentioning

confidence: 99%

The Efficiency of Stem Cells (SCs) Differentiation into Functional Hepatocytes for Treating Liver Disorders: A Systematic Review

Nemati

Ebrahimi

Abolhassani

et al. 2023

BioMed Research International

View full text Add to dashboard Cite

Stem cells provided new opportunity to treat various diseases, including liver disorders. Stem cells are unspecialized cells, stimulating influential research interest be indebted to their multipotent self-renewal capacity and differentiation characteristics into several specialized cell types. Many factors contribute to their differentiation into different cell types such as insulin producing cells, osteoblast, and hepatocytes. Accordingly, wide range methods and materials have been used to transform stem cells into hepatocytes, but effectiveness of differentiation is different and depends on several factors such as cell-to-cell adhesion, cell-to-cell contact, and cell biological change. Search was done in PubMed, Scopus, and WOS to evaluate results of studies about stem cells differentiation for higher efficacy. Among more than 28000 papers, 51 studies were considered eligible for more evaluations. Results indicated that most studies were performed on mesenchymal stem cells compared with other types. Acute liver failure was the most investigated liver disorder, and tissue engineering was the most investigated differentiation methods. Also, functional parameters were the most evaluated parameters in assessing differentiation efficacy. We summarize recent advances in increasing efficiency of stem cells differentiation using varied materials, since promising results of this review, further studies are needed to assess efficiency and safety of these cells transplantation in some liver disease treatment.

show abstract

Section: Resultsmentioning

confidence: 99%

The Efficiency of Stem Cells (SCs) Differentiation into Functional Hepatocytes for Treating Liver Disorders: A Systematic Review

Nemati

Ebrahimi

Abolhassani

et al. 2023

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…Vitamin E pretreatment of Wharton's jelly-derived MSCs (Vit E-WJMSCs) ameliorated CCl4-induced hepatocyte injury in vitro. Furthermore, Vit E-WJMSCs recovered CCl4-induced liver fibrosis in rats and increased homing of WJMSCs [153]. In vitro, GSH or MT preconditioning improved ADMSC survival and migration.…”

Section: Pretreatment Of Mscsmentioning

confidence: 90%

“…Due to the severe oxidative stress microenvironment in end-stage liver diseases, preincubation of MSCs with antioxidants improves the effectiveness of MSCs [153]. Melatonin (MT) is an endogenous neurohormone produced mainly by the pineal gland that exerts immunomodulatory, anti-inflammatory, cytoprotective, and antioxidant effects [154].…”

Section: Pretreatment Of Mscsmentioning

confidence: 99%

Advance of Mesenchymal Stem Cells in Chronic End-Stage Liver Disease Control

Gao

Yin

Ren

2022

Stem Cells International

View full text Add to dashboard Cite

The chronic liver diseases will slowly develop into liver fibrosis, cirrhosis, and even liver cancer if no proper control is performed with high efficiency. Up to now, the most effective treatment for end-stage liver diseases is liver transplantation. However, liver transplantation has the problems of donor deficiency, low matching rate, surgical complications, high cost, and immune rejection. These problems indicate that novel therapeutic strategies are urgently required. Mesenchymal stem cells (MSCs) are somatic stem cells with multidirectional differentiation potential and self-renewal ability. MSCs can secrete a large number of cytokines, chemokines, immunomodulatory molecules, and hepatotrophic factors, as well as produce extracellular vesicles. They alleviate liver diseases by differentiating to hepatocyte-like cells, immunomodulation, homing to the injured site, regulating cell ferroptosis, regulating cell autophagy, paracrine effects, and MSC-mitochondrial transfer. In this review, we focus on the main resources of MSCs, underlying therapeutic mechanisms, clinical applications, and efforts made to improve MSC-based cell therapy efficiency.

show abstract

“…Preconditioning of MSCs with MT showed lower expressions of TGF-β1 and Bax and lowered ALT content but higher expressions of MMPs and Bcl2 with the MSCs group in the treatment of liver fibrosis ( 105 ). Similarly, vitamin E (Vit E) is widely considered one of the strongest antioxidants in nature, Vit E pretreated MSCs reduced the Timps/Mmps and promoted the degradation of ECM protein by inhibiting TGF-β1 signaling pathway during liver fibrosis ( 106 ). Most medications for liver fibrosis promote MSCs, but some may limit their viability or function.…”

Section: Discussionmentioning

confidence: 99%

Structural and Temporal Dynamics of Mesenchymal Stem Cells in Liver Diseases From 2001 to 2021: A Bibliometric Analysis

et al. 2022

View full text Add to dashboard Cite

BackgroundMesenchymal stem cells (MSCs) have important research value and broad application prospects in liver diseases. This study aims to comprehensively review the cooperation and influence of countries, institutions, authors, and journals in the field of MSCs in liver diseases from the perspective of bibliometrics, evaluate the clustering evolution of knowledge structure, and discover hot trends and emerging topics.MethodsThe articles and reviews related to MSCs in liver diseases were retrieved from the Web of Science Core Collection using Topic Search. A bibliometric study was performed using CiteSpace and VOSviewer.ResultsA total of 3404 articles and reviews were included over the period 2001-2021. The number of articles regarding MSCs in liver diseases showed an increasing trend. These publications mainly come from 3251 institutions in 113 countries led by China and the USA. Li L published the most papers among the publications, while Pittenger MF had the most co-citations. Analysis of the most productive journals shows that most are specialized in medical research, experimental medicine and cell biology, and cell & tissue engineering. The macroscopical sketch and micro-representation of the whole knowledge field are realized through co-citation analysis. Liver scaffold, MSC therapy, extracellular vesicle, and others are current and developing areas of the study. The keywords “machine perfusion”, “liver transplantation”, and “microRNAs” also may be the focus of new trends and future research.ConclusionsIn this study, bibliometrics and visual methods were used to review the research of MSCs in liver diseases comprehensively. This paper will help scholars better understand the dynamic evolution of the application of MSCs in liver diseases and point out the direction for future research.

show abstract

Vitamin E pretreated Wharton’s jelly-derived mesenchymal stem cells attenuate CCl4-induced hepatocyte injury in vitro and liver fibrosis in vivo

Cited by 16 publications

References 49 publications

The Efficiency of Stem Cells (SCs) Differentiation into Functional Hepatocytes for Treating Liver Disorders: A Systematic Review

The Efficiency of Stem Cells (SCs) Differentiation into Functional Hepatocytes for Treating Liver Disorders: A Systematic Review

Advance of Mesenchymal Stem Cells in Chronic End-Stage Liver Disease Control

Structural and Temporal Dynamics of Mesenchymal Stem Cells in Liver Diseases From 2001 to 2021: A Bibliometric Analysis

Contact Info

Product

Resources

About