Vitamin E Supplementation and In Vivo Immune Response in Healthy Elderly Subjects

Meydani, Simin Nikbin; Meydani, Mohsen; Blumberg, Jeffrey B.; Leka, Lynette S.; Siber, George R.; Loszewski, R.; Thompson, Chris; Pedrosa, Marcos; Diamond, RD; Stollar, B. David

doi:10.1001/jama.1997.03540410058031

Cited by 444 publications

(167 citation statements)

References 29 publications

Supporting

Mentioning

154

Contrasting

Unclassified

Order By: Relevance

“…The age-related decline in some of the T cell immune parameters such as proliferative response and IL-2 production has been contributed to the age-associated increase in macrophage PGE 2 production resulting from increased cyclooxygenase 2 activity in the old mice (15,46). The effect of supplemental vitamin E on lowering macrophage PGE 2 production and the resulting enhancement of cell-mediated immunity have previously been described both for mice and for human subjects (15)(16)(17)46). However, other effects of supplemental vitamin E on T cell immunity that may not involve PGE 2 have been suggested (17).…”

Section: Discussionmentioning

confidence: 98%

“…In addition, measures of cell-mediated immune function, such as delayed-type hypersensitivity (DTH) response, in vitro T cell proliferation and IL-2 production in response to the T cell mitogen Con A were increased compared with those fed 30 ppm (an adequate dietary level) of vitamin E. A dietary supplement of 800 mg of vitamin E for 30 days to men and woman over 60 years of age, increased DTH, mitogenic response to Con A, and the production of IL-2 (15). A subsequent randomized double-blind, placebo-controlled trial by Meydani et al (16) found that vitamin E supplementation improved DTH response in a group of healthy elderly subjects. In addition, Ab titer against T cell-dependent hepatitis B vaccine was significantly increased in subjects receiving supplemental vitamin E. Previous studies from our laboratory show that vitamin E exerts its effect in part by reducing macrophage PGE 2 production (14,17).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Vitamin E-Enhanced IL-2 Production in Old Mice: Naive But Not Memory T Cells Show Increased Cell Division Cycling and IL-2-Producing Capacity

Adolfsson

Huber

Meydani

2001

The Journal of Immunology

Self Cite

130

113

View full text Add to dashboard Cite

Aging is associated with reduced T cell function, as demonstrated by decreased T cell proliferation and IL-2 production. These changes respond to supplemental vitamin E both in animals and humans, in part by the reduction of T cell suppressive PGE2, the production of which by macrophages is increased with age. To evaluate whether vitamin E has a direct PGE2-independent effect on T cell responses, T cells purified from the spleens of young and old mice were preincubated with vitamin E or vehicle control. Activation-induced cell division of T cells from old mice was lower than that by young, and the production of IL-2 following 48-h activation was less by T cells from old mice. There was an age-related decline in both the number of IL-2+ T cells and the amount of IL-2 produced per cell. Despite decreased IL-2 protein at 48 h, the expression of IL-2 mRNA at 6 h and IL-2 protein production at 6 and 16 h was greater by T cells from old mice compared with that of young. Age-related decline in cell division and IL-2 production at 48 h was only observed within the naive T cell subpopulation. Vitamin E increased both cell-dividing and IL-2-producing capacity of naive T cells from old mice, with no effect on memory T cells. These data indicate that naive T cells exhibit the greatest age-related defect and show for the first time that supplemental vitamin E has direct immunoenhancing effect on naive T cells from old mice.

show abstract

Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 99%

Vitamin E-Enhanced IL-2 Production in Old Mice: Naive But Not Memory T Cells Show Increased Cell Division Cycling and IL-2-Producing Capacity

Adolfsson

Huber

Meydani

2001

The Journal of Immunology

Self Cite

130

113

View full text Add to dashboard Cite

show abstract

“…The vitamin E levels were selected based on our previous studies in which 500 ppm vitamin E was shown to significantly improve T cell-mediated function in old mice (4,7). In addition, this is the level of vitamin E that results in similar fold increases (2-to 2.7-fold) in blood ␣-tocopherol levels of mice compared with those observed in humans following consumption of 200 -800 mg/day for a short period of time (4,10,11). All animal procedures were approved by the HNRCA Animal Care and Use Committee.…”

Section: Animals and Dietsmentioning

confidence: 99%

Age and Vitamin E-Induced Changes in Gene Expression Profiles of T Cells

Han

Adolfsson

Lee

et al. 2006

The Journal of Immunology

Self Cite

View full text Add to dashboard Cite

T cells are vulnerable to age-associated changes. Vitamin E has been shown to improve T cell functions in the old. We studied gene expression profiles of T cells to better understand the underlying mechanisms of age and vitamin E-induced changes in T cell function. Young and old C57BL mice were fed diets containing 30 (control) or 500 (supplemented) ppm of vitamin E for 4 wks. Gene expression profiles of T cells were assessed using microarray analysis with/without anti-CD3/anti-CD28 stimulation. Genes associated with cytokines/chemokines, transcriptional regulation, signal transduction, cell cycle, and apoptosis were significantly up-regulated upon stimulation. Higher SOCS3 and lower growth factor independent 1 (Gfi-1) expression in old T cells may contribute to age-associated decline in proliferation. Higher Gadd45 and lower Bcl2 expression may contribute to increased apoptosis in old T cells. Vitamin E supplementation resulted in higher expression of genes involved in cell cycle regulation (Ccnb2, Cdc2, Cdc6) in old T cells. Vitamin E supplementation resulted in higher up-regulation of IL-2 expression in young and old T cells and lower up-regulation of IL-4 expression in old T cells following stimulation. These findings suggest that aging has significant effects on the expression of genes associated with signal transduction, transcriptional regulation, and apoptosis pathways in T cells, and vitamin E has a significant impact on the expression of genes associated with cell cycle and Th1/Th2 balance in old T cells. Further studies are needed to determine whether these changes are due to the effects of aging at a single-cell level or to the shift in the ratio of naïve:memory T cells with age.

show abstract

“…Other components of the capsules include fucoidans 12,13) , vitamin E [14][15][16] , zinc 17,18) , vitamin B6 and coenzyme Q10 19) . These supplements have been used in traditional Chinese medicine as nutritional fortification elements and are believed to improve immune function.…”

Section: Discussionmentioning

confidence: 99%

Effects of Health Food Containing Cistanche Deserticola Extract on QOL and Safety in Elderly: An Open Pilot Study of 12-week Oral Treatment

et al. 2011

View full text Add to dashboard Cite

Objective: The purpose of the present study was to elucidate the effects and safety of Cistanche deserticola Y. C. Ma extract (CDX), which was given to elderly persons as a 12-week oral administration via CDX containing health food. Methods: A non-controlled open study was conducted with 25 elderly persons, without severe illness. Participants were given test product containing 100 mg of CDX as well as vitamin E, vitamin B6, ubiquinone, zinc and fukoidan, by oral administration for 12 weeks, with examination conducted before and after the study. Results: Subjective symptoms of "tired eyes" and "feeling tired all the time" were significantly improved after 12 weeks. With regard to anthropometric measurements, pulse rate was significantly reduced (-8.0%, p = 0.002). Biochemical examinations showed significant changes in white blood cell count (-14.1%, p < 0.001), platelet count (-4.3%, p = 0.040), albumin (-3.7%, p < 0.001), albumin/globulin ratio (-3.7%, p = 0.016), and fasting blood sugar (-10.2%, p = .039). Immune function was significantly improved with elevation of percentage of CD4 positive cells (6.1%, p = 0.003), CD4/CD8 ratio (20.2%, p = 0.002) and natural killer (NK) cell activity (11.7%, p = 0.024) accompanied by a decrease in percentage of CD8 positive cells (-7.7%, p = 0.022). Arteriosclerosis examinations by fingertip acceleration pulse wave analysis showed significant improvement in vascular age (-4.2%, p = 0.016) and significant decrease in cardio ankle vascular index (CAVI) (right: -10.9%, p < 0.001, left: -12.6%, p <0.001). Conclusion:The test product appears to promote quality of life by decreasing fatigue, activating immune function and favorably affecting the vascular system in the elderly. No severe adverse effects were observed during the study.

show abstract

Vitamin E Supplementation and In Vivo Immune Response in Healthy Elderly Subjects

Abstract: Our results indicate that a level of vitamin E greater than currently recommended enhances certain clinically relevant in vivo indexes of T-cell-mediated function in healthy elderly persons. No adverse effects were observed with vitamin E supplementation.

Cited by 444 publications

References 29 publications

Vitamin E-Enhanced IL-2 Production in Old Mice: Naive But Not Memory T Cells Show Increased Cell Division Cycling and IL-2-Producing Capacity

Vitamin E-Enhanced IL-2 Production in Old Mice: Naive But Not Memory T Cells Show Increased Cell Division Cycling and IL-2-Producing Capacity

Age and Vitamin E-Induced Changes in Gene Expression Profiles of T Cells

Effects of Health Food Containing Cistanche Deserticola Extract on QOL and Safety in Elderly: An Open Pilot Study of 12-week Oral Treatment

Contact Info

Product

Resources

About