Vitamin K and osteoporosis: Myth or reality?

Palermo, Andrea; Tuccinardi, Dario; D’Onofrio, Luca; Watanabe, Mikiko; Maggi, Daria; Maurizi, Anna Rita; Greto, Valentina; Buzzetti, Raffaella; Napoli, Nicola; Pozzilli, Paolo; Manfrini, Silvia

doi:10.1016/j.metabol.2017.01.032

Cited by 117 publications

(94 citation statements)

References 97 publications

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“…However, little was known about the functions of the top four metabolites (Table 1) and their roles on bone metabolism warrants further functional analysis. On the other hand, our analysis did not detect several metabolites that were previously known to be causally associated with BMD, such as vitamin K (Palermo et al 2017). This is mainly because that some of these metabolites (e.g., vitamin K) were not included in the metabolomics GWAS dataset (Shin et al 2014).…”

Section: Discussioncontrasting

confidence: 78%

Inferring causal relationships between phenotypes using summary statistics from genome-wide association studies

et al. 2018

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Genome-wide association studies (GWAS) have successfully identified numerous genetic variants associated with diverse complex phenotypes and diseases, and provided tremendous opportunities for further analyses using summary association statistics. Recently, Pickrell et al. developed a robust method for causal inference using independent putative causal SNPs. However, this method may fail to infer the causal relationship between two phenotypes when only a limited number of independent putative causal SNPs identified. Here, we extended Pickrell's method to make it more applicable for the general situations. We extended the causal inference method by replacing the putative causal SNPs with the lead SNPs (the set of the most significant SNPs in each independent locus) and tested the performance of our extended method using both simulation and empirical data. Simulations suggested that when the same number of genetic variants is used, our extended method had similar distribution of test statistic under the null model as well as comparable power under the causal model compared with the original method by Pickrell et al. But in practice, our extended method would generally be more powerful because the number of independent lead SNPs was often larger than the number of independent putative causal SNPs. And including more SNPs, on the other hand, would not cause more false positives. By applying our extended method to summary statistics from GWAS for blood metabolites and femoral neck bone mineral density (FN-BMD), we successfully identified ten blood metabolites that may causally influence FN-BMD. We extended a causal inference method for inferring putative causal relationship between two phenotypes using summary statistics from GWAS, and identified a number of potential causal metabolites for FN-BMD, which may provide novel insights into the pathophysiological mechanisms underlying osteoporosis.

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Section: Discussioncontrasting

confidence: 78%

Inferring causal relationships between phenotypes using summary statistics from genome-wide association studies

et al. 2018

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“…Finally, the status of vitamin K was not measured directly, because vitamin K is a soluble vitamin with many isoforms, and vitamin K plasma value alone is not sufficient to assess its real status. 27 In conclusion, bone quality markers did not change significantly after ADT. Whereas, it was confirmed that BMD decreased significantly after ADT.…”

Section: Discussionmentioning

confidence: 77%

“…SXR stimulates proteins, such as tsukushin and matrilin‐2, which are associated with collagens to promote collagen‐accumulation in osteoblastic cells . A prospective study reported the efficacy of vitamin K supplementation for BMD and bone fractures . In a randomized trial carried out by Knapen et al ., for 3 years healthy postmenopausal women received a placebo or vitamin K2 supplements, menaquinone‐7 (MK‐7, 180 μg/day).…”

Section: Discussionmentioning

confidence: 99%

“…Second, the effect of denosumab could not be verified, because no patient received denosumab in the present cohort. Finally, the status of vitamin K was not measured directly, because vitamin K is a soluble vitamin with many isoforms, and vitamin K plasma value alone is not sufficient to assess its real status …”

Section: Discussionmentioning

confidence: 99%

“…26 A prospective study reported the efficacy of vitamin K supplementation for BMD and bone fractures. 27 In a randomized trial carried out by Knapen et al, for 3 years healthy postmenopausal women received a placebo or vitamin K2 supplements, menaquinone-7 (MK-7, 180 lg/day). The height loss of the vertebrae was significantly lower in the MK-7 group than in the placebo group after 2 and 3 years.…”

Section: Discussionmentioning

confidence: 99%

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Short‐term impact of androgen deprivation therapy on bone strength in castration‐sensitive prostate cancer

et al. 2019

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Objectives To prospectively evaluate changes in bone quality and bone mineral density after androgen deprivation therapy in castration‐sensitive prostate cancer. Methods A total of 32 patients with castration‐sensitive prostate cancer who were scheduled for androgen deprivation therapy for >12 months were included. The bone mineral density of the femoral neck and lumbar spine was evaluated before, and 6 and 12 months after androgen deprivation therapy. Bone metabolic (serum undercarboxylated osteocalcin, tartrate‐resistant acid phosphatase 5b and procollagen type I propeptides) and bone quality markers (plasma pentosidine and homocysteine) were measured before, and 3, 6 and 12 months after androgen deprivation therapy. Results The median patient age was 71 years. A total of 17 patients were treated primarily with androgen deprivation therapy, and 15 were treated with androgen deprivation therapy in combination with definitive radiotherapy. Bone quality markers did not change substantially after androgen deprivation therapy. Bone mineral density decreased significantly after 12 months of androgen deprivation therapy. Serum undercarboxylated osteocalcin and tartrate‐resistant acid phosphatase 5b levels increased significantly 3 months after androgen deprivation therapy, but procollagen type I propeptides levels stayed unchanged. Conclusions Bone quality markers do not change substantially after androgen deprivation therapy, whereas bone mineral density decreases significantly. Bone turnover markers might play an important role in monitoring bone health during androgen deprivation therapy.

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Simple and Cost‐Effective Electrochemical Approach for Monitoring of Vitamin K in Green Vegetables

et al. 2019

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This work presents a simple and sensitive electrochemical sensor for the determination of total vitamin K (K1 and K2) using a disposable screen‐printed graphene electrode (SPGE). The application for the determination of vitamin K1 in green vegetables by this sensor was developed. The proposed method is based on controlling of negative potential for seconds and scanning it to a positive for oxidation analysis. The capacitance of SPGE was studied and it showed a higher sensitivity for vitamin K determination in comparison to carbon. The parameters, such as the pH of electrolytes, accumulation potential, accumulation time, etc. were investigated. The limit of detection was observed at 0.099 μg mL−1. This method was successfully applied for the determination of the vitamin K1 in various green vegetables. Therefore, the proposed method can be used for quality control of vitamin K1 in natural samples to create the food composition table.

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Vitamin K and osteoporosis: Myth or reality?

Cited by 117 publications

References 97 publications

Inferring causal relationships between phenotypes using summary statistics from genome-wide association studies

Inferring causal relationships between phenotypes using summary statistics from genome-wide association studies

Short‐term impact of androgen deprivation therapy on bone strength in castration‐sensitive prostate cancer

Simple and Cost‐Effective Electrochemical Approach for Monitoring of Vitamin K in Green Vegetables

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