Volatile Components of Peel and Leaf Oils of Lemon and Lime Species

Lota, Marie-Laure; Serra, Dominique de Rocca; Tomi, Fe Ä Lix; Jacquemond, Camille; Casanova, Joseph

doi:10.1021/jf010924l

Cited by 228 publications

(208 citation statements)

References 14 publications

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“…Terpenoids used in this study are componential monoterpenoids, diterpenoids, and triterpenoids in herbal medicines and natural products. (R)-(ϩ)-citronellal, (S)-(Ϫ)-␤-citronellol, ␣-terpinene, terpinolene, and (Ϫ)-␤-pinene are contained in essential oils and present in Zanthoxyli Fructus and some edible plants (Sakai et al, 1968;Sun and Petracek, 1999;Lota et al, 2002). Abietic acid is a major component of the rosin fraction of turpentine from pines and other conifers (Dewick, 2001).…”

Section: Discussionmentioning

confidence: 99%

Inhibitory Effects of Terpenoids on Multidrug Resistance-Associated Protein 2- and Breast Cancer Resistance Protein-Mediated Transport

Yoshida¹,

Takada²,

Yamamura³

et al. 2008

Drug Metab Dispos

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ABSTRACT:The possibility of interactions between natural products/supplements and conventional prescription medicines is one of the most important issues in pharmacotherapeutic safety. Recently, we reported that some terpenoids such as (R)-(؉)-citronellal and glycyrrhetic acid, which are present in herbal medicines, can act as inhibitors of P-glycoprotein (MDR1/ABCB1). In the present study, the effects of seven terpenoids on multidrug resistance-associated protein 2 (MRP2/ABCC2) and breast cancer resistance protein (BCRP/ ABCG2)-mediated transport were investigated in vitro. Membrane vesicles were prepared from MRP2 cDNA transfected Sf9 cells derived from pupal ovarian tissue of Spodoptera frugiperda, a fall armyworm, and BCRP cDNA transfected LLC-PK1 cells derived from porcine kidney. MRP2-or BCRP-mediated efflux transport was measured as ATP-dependent accumulation of [ 3 H]estradiol 17-␤-D-glucuronide (E 2 17␤G) into membrane vesicles collected by a rapid filtration technique. The effects of (R)-(؉)-citronellal, (S)-(؊)-␤-citronellol, ␣-terpinene, terpinolene, (؊)-␤-pinene

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Section: Discussionmentioning

confidence: 99%

Inhibitory Effects of Terpenoids on Multidrug Resistance-Associated Protein 2- and Breast Cancer Resistance Protein-Mediated Transport

Yoshida¹,

Takada²,

Yamamura³

et al. 2008

Drug Metab Dispos

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“…c MS, identifi cation based on mass spectral data; RI, identifi cation based on retention index relative to standard n-alkanes; AT, identifi cation based on co-chromatography with authentic samples. (Choi et al, 2000;Lota et al, 2002).…”

Section: Analysis Of the Volatile Compoundsmentioning

confidence: 99%

Chemical Composition of the Essential Oils of Variegated Pink-Fleshed Lemon (Citrus x limon L. Burm. f.) and their Anti-Inflammatory and Antimicrobial Activities

Hamdan

Ashour

Mulyaningsih

et al. 2013

Zeitschrift Für Naturforschung C

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The volatile secondary metabolites of essential oils from fruit peel and leaves of variegated pink-fl eshed lemon (Citrus x limon) were investigated using GLC and GLC-MS (gas-liquid chromatography-mass spectroscopy). Altogether 141 compounds were identifi ed and quantifi ed, accounting for 99.59% and 96.33% of the total hydrodistilled peel and leaf oil, respectively. Limonene occurred in higher amounts in fruit peel (52.73%) than in leaf oil (29.13%). Neral (12.72%), neryl acetate (8.53%), ρ-menth-1-en-7-al (4.63%), β-pinene (6.35%), and nerol (4.42%) were the most abundant constituents in leaf oil, whereas γ-terpinene (9.88%), β-pinene (7.67%), geranial (4.44%), and neral (3.64%) dominated in the fruit peel oil. The antioxidant, anti-infl ammatory, antitrypanosomal, and antimicrobial activities of the fruit peel essential oil were evaluated. The oil had a low antioxidant activity with an IC 50 value of (26.66 ± 2.07) mg/ml as compared to the effi cient antioxidant ascorbic acid [IC 50 (16.32 ± 0.16) μg/ml]. The oil moderately inhibited soybean 5-lipoxygenase (5-LOX) with an IC 50 value of (32.05 ± 3.91) μg/ml and had moderate antitrypanosomal activity [IC 50 (60.90 ± 0.91) μg/ml]. In addition, moderate antimicrobial activities were detected against Gram-positive bacteria (Bacillus subtilis, Staphylococcus capitis, Micrococcus luteus), one Gram-negative bacterium (Pseudomonas fl uorescens), and yeasts (Saccharomyces cerevisiae, Candida parapsilosis).

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“…Numerous studies have been performed on the chemical composition, antimicrobial, antifungal, antioxidant and radical scavenging abilities of the essential oils of peel and leaf of various species and/or cultivars of lemon around the world, where limonene has been always the prominent component found in all peel essential oils, whereas the leaf essential oil was generally rich in limonene, in some case other compounds were the major constituents (5,6,(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22).…”

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confidence: 99%

Chemical Composition and Biological Activities of Lemon (Citrus limon) Leaf Essential Oil

Hojjati

Barakat

2017

Nutr Food Sci Res

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A B S T R A C TBackground and Objectives: Essential oils and their compounds are getting increasing interest due to their multipurpose functionals as alternatives to the artificial preservatives. The aim of this study was to extract and identify the volatile constituents of essential oil of Citrus lemon leaf and to evaluate its antioxidant and antibacterial abilities. Materials and Methods:The essential oil was extracted using Clevenger apparatus and characterized by means of gas chromatography mass spectrometry (GC-MS). Folin-Ciocalteu method was used to determine the total phenolic equivalent (TPC). The antioxidant properties of the essential oil were evaluated by 2,2-diphenylpicrylhydrazyl (DPPH) assay and the detection of inhibitory effect of the essential oil at various concentrations (0.025-10 mg/mL) on Staphylococcus aureus, Bacillus cereus, Streptococcus faecium, Escherichia coli, Salmonella typhi and Shigella dysentery was carried out by agar disc-diffusion method and then Minimum Inhibitory Concentration (MIC) assay was evaluated.Results: GC-MS analysis allowed the identification of twenty-seven compounds and linalool (30.62%), geraniol (15.91%), α-terpineol (14.52%), and linalyl acetate (13.76%) were the main constituents. TPC of essential oil was 14.73 mg gallic acid equivalent/g dry plant material and its IC 50 value was found to be 0.98 mg/mL in DPPH test, so lemon leaf essential oil showed good free radical scavenging capacity at all studied concentrations. However the antioxidant capacity increased with increasing concentration of the essential oil. The results showed that increasing the essential oil concentration, increases the zone of inhibition, so that the highest antibacterial activity was observed at 10 mg/mL of essential oil. The results of antimicrobial activity by disc diffusion method showed that essential oil exhibited maximum zone inhibition against Gram-positive bacteria including B. cereus, S. aureus and S. faecium, whereas the minimum zone inhibition was shown by S. typhi and S. dysentery as Gram-negative pathogens at the same concentrations. The highest MIC showed by S. aureus and S. dysentery, whereas the least MIC value was observed with B. cereus and S. typhi. Conclusions:The results obtained in this study have shown the moderate biological potential of essential oil of C. limon leaf is probably due to its particular chemical composition, mainly the high amounts of linalool. Therefore, this essential oil could be used to raise the shelf life of foods as a natural preservative ingredient.

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Volatile Components of Peel and Leaf Oils of Lemon and Lime Species

Cited by 228 publications

References 14 publications

Inhibitory Effects of Terpenoids on Multidrug Resistance-Associated Protein 2- and Breast Cancer Resistance Protein-Mediated Transport

Inhibitory Effects of Terpenoids on Multidrug Resistance-Associated Protein 2- and Breast Cancer Resistance Protein-Mediated Transport

Chemical Composition of the Essential Oils of Variegated Pink-Fleshed Lemon (Citrus x limon L. Burm. f.) and their Anti-Inflammatory and Antimicrobial Activities

Chemical Composition and Biological Activities of Lemon (Citrus limon) Leaf Essential Oil

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