Voltammetric behaviour of the antimycotic terbinafine at the hanging mercury drop electrode

Voltammetric determination of terbinafine in biological fluid at glassy carbon electrode modified by cysteic acid/carbon nanotubes composite film

“…There are only a limited number of techniques described for the determination of terbinafine in its pharmaceutical formulations including capillary zone electrophoresis [4], HPLC [5,6], UV−spectrophotometric method [7][8][9], agar diffusion method [10] and polarography [11]. Pharmaceutical analysis in biological fluids plays an important role in studies of pharmacokinetics and pharmacodynamics both in experimental animals and human.…”

“…Electrochemical sensors satisfy many of the requirements for such tasks particularly owing to their inherent specificity, rapid response, sensitivity and simplicity of preparation. Up to date, there is only an available polarography with the hanging mercury drop electrode for the determination of terbinafine in the literatures [11]. Arranz et al determined terbinafine at −1.47 V vs. Ag/AgCl by square wave voltammetry and differential pulse polarography with a hanging mercury drop electrode [11].…”

“…Up to date, there is only an available polarography with the hanging mercury drop electrode for the determination of terbinafine in the literatures [11]. Arranz et al determined terbinafine at −1.47 V vs. Ag/AgCl by square wave voltammetry and differential pulse polarography with a hanging mercury drop electrode [11]. This technique showed good reproducibility and sensitivity.…”

The Analytical Applications of Square Wave Voltammetry on Pharmaceutical Analysis

“…Arranz et al [137] have designed the voltammetric methods for the quantitative determination of terbinafine. Terbinafine is adsorbed on a hanging mercury drop electrode at pH 6.0 and gives a single wave at -1.47 vs Ag/AgCl reference electrode, due to olefinic double bond reduction.…”

Terbinafine: optimization of a LC method for quantitative analysis in pharmaceutical formulations and its application for a tablet dissolution test

“…On the other hand, the literature describes several methods to quantify TBF raw material, like, non-aqueous titrimetry, voltametry, UV derivative, capillary electrophoresis and high performance liquid chromatography (HPLC). [6][7][8][9][10] Also, TBF has been determined in biological fluids by HPLC technique and microbiological bioassays. [11][12][13][14][15] Another HPLC method has been used to determine the drug in tablets and creams.…”