Voltammetric Determination of Lidocaine and Its Toxic Metabolite in Pharmaceutical Formulation and Milk Using Carbon Paste Electrode Modified with C18 Silica

Saad, Ahmed S.; Al-Alamein, Amal M. Abou; Galal, Maha Mohammed; Zaazaa, Hala E.

doi:10.1149/2.0921902jes

Cited by 20 publications

(6 citation statements)

References 37 publications

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“…The electrooxidation related to proton exchange in buffer solution. [26][27][28] Optimization of experimental conditions.-Effect of pH.-The effect of pH is well known to have a prime impact on the response of organic and inorganic drug compounds. 29 This parameter was studied to detect the oxidation process of IMD at (bare CPE, GNP/MWCNT) in pH range 2 to 10 using B-R buffer.…”

Section: Resultsmentioning

confidence: 99%

Nano Green Voltammetric Determination of Imidocarb Dipropionate and Its Residues in Bovine Meat, Milk and Urine Samples

Atty

Zaazaa

Morsy

et al. 2020

J. Electrochem. Soc.

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Imidocarb dipropionate (IMD) is an antimicrobial agent that is widely used in veterinary medicine for treatment of many diseases especially anaplasma marginale in cattle. This may lead to the retention of its residues in edible bovine tissues, milk and urine samples. Thus the quick determination of minor concentrations of IMD is of great interest to ensure food safety. A novel electrochemical sensor was introduced for the sensitive, fast and selective determination of IMD in drug substance and commercial product, furthermore its application to determine IMD residues in bovine meat, milk and urine samples. The prepared nanoparticles sensor was based on a multiwalled carbon nanotube composite modified with gold nanoparticles GNPs/MWCNT. The linear response obtained for IMD using the GNP/MWCNT was found to be over the range of 0.20–3.6 n mol l−1 with a good linearity and high correlation (0.9999). The limits of detection and quantification were found to be 36 p mol l−1 and 109 p mol l−1 respectively. The developed method was simple, rapid, economic, and challenging to green chemistry. The high sensitivity, good reproducibility, and wide linear range mark the modified electrode suitable for determination of the residues in bovine meat and milk as real samples with excellent recoveries.

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Section: Resultsmentioning

confidence: 99%

Nano Green Voltammetric Determination of Imidocarb Dipropionate and Its Residues in Bovine Meat, Milk and Urine Samples

Atty

Zaazaa

Morsy

et al. 2020

J. Electrochem. Soc.

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“…Some model compounds were used for understanding the electro-oxidation mechanism of CAM and ANG. [44][45][46] The electro-oxidation related to proton exchange in buffer solution, one electron is liberated in the oxidation process, due to the oxidation of tertiary amine group in ANG 47 and secondary amine group in CAM. 48 A schematic diagram representing the oxidation of CAM and ANG at the ZnO/IL/MCPE is shown in schematic 1.…”

Section: Oxidation Mechanism Of Ang and Cammentioning

confidence: 99%

A Newly Developed Electrochemical Method for the Simultaneous Determination of Camylofin and Analgine in Pharmaceutical Preparation and Biological Fluids

Atty

Abdallah

Abdelrahman

et al. 2019

J. Electrochem. Soc.

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A simple, rapid and highly sensitive electrochemical sensing platform has been developed for the simultaneous determination of Camylofin (CAM) and Analgine (ANG). The electrochemical oxidation based on bare and bulk zinc oxide nanoparticles (ZnO/NPs) and ionic liquid (IL) modified carbon paste electrode (ZnO/IL/MCPE) have been studied using cyclic voltammetry and square-wave voltammetric techniques. Under optimum conditions, the linearity range was from 1 μmol L −1 to 100 μmol L −1 and 0.2 μmol L −1 to 100 μmol L −1 for ANG and CAM, at bare and at ZnO/IL/MCPE, respectively in pH 7. The ZnO/IL/MCPE sensor was then explored toward the analysis of ANG and CAM in pharmaceutical formulation, real human serum and urine with excellent recoveries. The obtained results were compared successfully with respect to those obtained using the reported method. Moreover, this sensor is sensitive for the determination of ANG and CAM in the presence of common interference molecules uric acid (UA) and ascorbic acid (AA). The fabricated ZnO/IL/MCPE was demonstrated to exhibit a high sensitivity, good stability toward the sensing of ANG and CAM and was successfully used as a clinical assay and in quality assurance of pharmaceutical products.

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“…PGEs have been successfully employed to fabricate sensors and biosensors by modification using various nanomaterials, recent advances in employing PGEs in electroanalysis have been reviewed [18][19][20][21][22][23][24]. Furthermore, a large number of different electrolytes and solvents can be used besides varieties of modifiers that can be added to increase both selectivity and sensitivity [25,26].…”

Section: Introductionmentioning

confidence: 99%

Voltammetric Determination of Oxybutynin Hydrochloride Utilizing Pencil Graphite Electrode Decorated with Gold Nanoparticles

et al. 2022

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A novel voltammetric method was successfully applied for the determination of an anticholinergic drug, oxybutynin hydrochloride (OXB). The method is concerned with electrooxidation of the drug on the surface of pencil graphite electrode (PGE). In order to enhance the electrode sensitivity and peak current, the electrode was coated with gold nanoparticles (Au-NPs) via electrochemical deposition using cyclic voltammetry from gold salt solution. The surface of Au-NPs modified PGE has been characterized using scanning electron microscopy and X-ray photoelectron spectroscopy. Various experi-mental variables were studied and optimized to enhance the sensor's response towards OXB. Quantitative determination of the drug was achieved in phosphate buffer pH 7.5 using differential pulse voltammetry by scanning the potential over range of 0.00 to 2.20 V with scan rate of 40 mV s À 1 . Validation of the method was achieved according to ICH guidelines. The method was found to be linear over concentration range (2.0 × 10 À 7 -1.0 × 10 À 6 M). The suggested sensor was efficiently developed for the quantitative determination of OXB in pure form, pharmaceutical dosage form and spiked plasma samples.

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Voltammetric Determination of Lidocaine and Its Toxic Metabolite in Pharmaceutical Formulation and Milk Using Carbon Paste Electrode Modified with C18 Silica

Cited by 20 publications

References 37 publications

Nano Green Voltammetric Determination of Imidocarb Dipropionate and Its Residues in Bovine Meat, Milk and Urine Samples

Nano Green Voltammetric Determination of Imidocarb Dipropionate and Its Residues in Bovine Meat, Milk and Urine Samples

A Newly Developed Electrochemical Method for the Simultaneous Determination of Camylofin and Analgine in Pharmaceutical Preparation and Biological Fluids

Voltammetric Determination of Oxybutynin Hydrochloride Utilizing Pencil Graphite Electrode Decorated with Gold Nanoparticles

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