Voltammetric Method for Simultaneous Determination of L-Dopa and Benserazide

Rabinca, Andreea Alexandra; Buleandră, Mihaela; Tache, Florentin; Mihailciuc, Constantin; Ciobanu, Adela Magdalena; Stefanescu, Dragos Cristian; Ciucu, Anton Alexandru

doi:10.2174/1573411012666160601161703

Cited by 14 publications

(13 citation statements)

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“…Blood samples were collected and were analysed using Ventana method for serum ionogram, including iron, calcium, sodium, potassium, chloride and magnesium ions. Besides the testing of biological markers, the subjects were given the DASS 21R questionnaire for depression, anxiety and stress assessment [48,53]. Statistical analysis.…”

Section: Methodsmentioning

confidence: 99%

The Role of Serum Ions Deficiencies in the Pathogenic Mechanisms of Oncological Depression – Psycho-Pharmacological Particularities

Ciobanu¹

2021

FARMACIA

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Cancer patients frequently present symptoms of depression and anxiety that influence the quality of life, compliance and adherence to treatment, disease progression and the overall survival. Psychiatric pathology could be related to the disturbance of serum ion levels, caused by the oncological or psychiatric status and the adverse effects of pharmacological treatment. This article is focused on assessing the relationship between anxiety, depression and stress and serum ion levels. Changes in the homeostasis of serum ions and pH may be factors that favour the risk of oncogenesis in the context of this psychiatric pathology. Knowledge of the involvement of serum ions in specific pathogenic mechanisms suggests the importance of monitoring them in oncological pathology with depression and helps to develop personalized psychopharmacological strategies. RezumatPacienții cu cancer prezintă frecvent simptome de depresie și anxietate care influențează calitatea vieții, complianța și aderența la tratament, evoluția bolii și supraviețuirea generală. Patologia psihiatrică ar putea fi legată de perturbarea nivelurilor serice ale ionilor, cauzată de statusul oncologic sau psihiatric și de efectele adverse ale tratamentului farmacologic. Prezentul articol este axat pe evaluarea relației dintre gradele de anxietate, depresie și stres și nivelul ionilor serici. Modificările homeostaziei ionilor serici și ale pH-ului pot fi factori care favorizează riscul de oncogeneză în contextul acestei patologii psihiatrice. Cunoașterea implicării ionilor serici în mecanisme patogenice specifice sugerează importanța monitorizării acestora în patologia oncologică cu depresie și ajută la elaborarea unor strategii psihofarmacologice personalizate.

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Section: Methodsmentioning

confidence: 99%

The Role of Serum Ions Deficiencies in the Pathogenic Mechanisms of Oncological Depression – Psycho-Pharmacological Particularities

Ciobanu¹

2021

FARMACIA

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“…It is noteworthy that the methodology of modification of the surface of the GCE is rapid and that the data obtained when compared with those present in the literature [23,[26][27][28][29][30][31][32][33] has performance as good as the sensors described; however, the preparation methodology of some is more laborious than the proposal in this work.…”

Section: Application In Pharmaceutical Formulationmentioning

confidence: 98%

An Electrochemical Sensor Based on Electroreduction of Graphene Oxide on a Glassy Carbon Electrode Using Multiple Pulse Amperometry for Simultaneous Determination of L-Dopa and Benserazide

Barbosa¹,

Oliveira²,

Pereira³

2020

Graphene Production and Application

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In this work, we described the development an electrochemical sensor based on electroreduction of graphene oxide (rGO) on a glassy carbon electrode (GCE) for simultaneous determination of l-Dopa and benserazide. For the elaboration of the GCE/rGO, the developed methodology was based on the electrochemical technique: multiple pulse amperometry (MPA). The MPA was more stable and efficient for the formation of rGO film, under optimum conditions (pH 6.00; concentration of rGO 2.00 mg mL −1 ; time 450 s; potentials −0.60, −0.70, −0.80, −0.90, −0.95, −1.00, −1.10, −1.20, and -1.30 V). After the film was formed, the cyclic voltammetry was used to detect LD and BZ in real samples and optimized conditions 0.05 mol L −1 PBS (pH 5.50). The linear range for the LD is 25-425 μmol L −1 and the BZ of 5-80 μmol L −1 . The limit of detection calculated was 17.10 (LD) and 2.99 (BZ) μmol L −1 .

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“…It is extremely important for the proper treatment of patients that needed L‐dopa that this should be done in a sufficient diagnostic way on‐site with a very fast continuous analytical procedure and sensor device detection on immediate at‐site taken biological fluids (urine and blood samples). However the majority of methods in Table 1 used glassy carbon electrode with a design that is unfortunately not quite suitable for on‐site work except two methods [22, 26] that used screen printed electrodes that may be suitable. Furthermore, although an electropolymerized film of 3,3′,3′′,3′′′‐tetraaminophthalocyanatonickel(II) (p‐Ni II TAPc) was used in the determination of L‐dopa it was only deposited on glassy carbon to form a glassy carbon (GC) electrode [18], applied to estimate the concentration of L‐dopa in commercially available tablets and not quite suitable for on‐site diagnostic work.…”

Section: Introductionmentioning

confidence: 99%

Application of a Tetraamino Cobalt(II) Phthalocyanine Modified Screen Printed Carbon Electrode for the Sensitive Electrochemical Determination of L‐Dopa in Pharmaceutical and Biological Samples

et al. 2021

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A novel synthesized tetraamino cobalt(II) phthalocyanine monomer was used for the fabrication of a sensor by electrochemical polymerization. A disposable electrochemical sensor based on the use of a screen printed carbon electrode covered with an electropolymerized film of tetraamino cobalt(II) phthalocyanine for the determination of L‐dopa in pharmaceutical tablets and biological samples was described. Cyclic voltammetry and electrochemical impedance spectroscopy were performed for the characterization of the bare and modified electrode. For the electrochemical detection of L‐dopa differential pulse voltammetry was used. The proposed method exhibits a good response towards electrooxidation of L‐dopa in the linear concentration range: from 0.1 to 1000.0 μmol L−1 in BRB pH=2.0, with a detection limit of 0.03 μmol L−1 and from 1 to 1000 μmol L−1 in PBS pH=7.4, with a detection limit of 0.33 μmol L−1. Due to the fact that the developed sensor was applied in two different types of real samples, two buffer media were used, BRB pH=2.0 for pharmaceutical and urine samples and PBS pH=7.4 for whole blood samples. The proposed pCoTAPc/SPCE was successfully applied for the determination of L‐dopa in pharmaceutical tablets, urine and in whole blood samples with satisfactory results.

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Voltammetric Method for Simultaneous Determination of L-Dopa and Benserazide

Cited by 14 publications

References 0 publications

The Role of Serum Ions Deficiencies in the Pathogenic Mechanisms of Oncological Depression – Psycho-Pharmacological Particularities

The Role of Serum Ions Deficiencies in the Pathogenic Mechanisms of Oncological Depression – Psycho-Pharmacological Particularities

An Electrochemical Sensor Based on Electroreduction of Graphene Oxide on a Glassy Carbon Electrode Using Multiple Pulse Amperometry for Simultaneous Determination of L-Dopa and Benserazide

Application of a Tetraamino Cobalt(II) Phthalocyanine Modified Screen Printed Carbon Electrode for the Sensitive Electrochemical Determination of L‐Dopa in Pharmaceutical and Biological Samples

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