Vulval intraepithelial neoplasia

Extensive vulval intraepithelial neoplasia treated with a new regime of systemic photodynamic therapy using meta‐tetrahydroxychlorin (Foscan®)

“…Treatment by local excision is both diagnostic and therapeutic but can be difficult when there is multifocal disease, and the results can be mutilating. Other treatments, such as 5‐fluorouracil, interferon, and bleomycin, have been used but, again, with only limited success, and these can be very painful 1 …”

Photodynamic therapy using meta-tetrahydroxyphenylchlorin (FoscanR) for the treatment of vulval intraepithelial neoplasia

“…Treatment by local excision is both diagnostic and therapeutic, but can be difficult when there is multifocal disease and the results can be mutilating. Other treatments such as 5‐fluorouracil, dinitrochlorobenzene, interferon and bleomycin have been used but again with only limited success, and these can be very painful 2 …”

“…Other treatments such as 5-fluorouracil, dinitrochlorobenzene, interferon and bleomycin have been used but again with only limited success, and these can be very painful. 2 Photodynamic therapy (PDT) is a relatively new technique with unique properties that make it attractive for the local treatment of superficial epithelial disorders. It involves selective photosensitization of a target tissue by means of a topically or systemically administered agent, which is then activated by light of a specific wavelength to produce an oxygen-dependent cytotoxic reaction.…”

Single‐episode photodynamic therapy and vulval intraepithelial neoplasia type III resistant to conventional therapy

“…Medical therapies including 5‐fluorouracil (5‐FU), dinitrochlorobenzene (DNCB), interferon‐α and bleomycin have been tried, with limited success 7 . Surgical excision in patients with extensive disease is both mutilating and associated with persistent disease in 39% 8 .…”

“…6 Medical therapies including 5-fluorouracil (5-FU), dinitrochlorobenzene (DNCB), interferon-a and bleomycin have been tried, with limited success. 7 Surgical excision in patients with extensive disease is both mutilating and associated with persistent disease in 1040 q 2000 British Association of Dermatologists 39%. 8 Carbon dioxide (CO 2 ) laser ablation is associated with an even higher recurrence rate, possibly due to the presence of disease in deep adnexal structures.…”