W09.210 Non-alcoholic fatty liver disease is associated with preclinical carotid atherosclerosis. A case-control study

Brea, Ángel; Mosquera, Daniel; Martin, E.; Arizti, Ana; Cordero, José Luis; Ros, Emilio

doi:10.1016/s1567-5688(04)90209-2

Cited by 2 publications

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“…It is suggested that abnormal lipid and lipoprotein metabolism or production of proinflammatory factors contribute to cardiovascular disease (6,14,15). The novel findings of the present study are 1) in the absence of other risk factors, hyperhomocysteinemia stimulates MCP-1 production in the liver, 2) Hcy-induced MCP-1 expression in hepatocytes is mediated via AP-1 activation, 3) Hcy can directly increase the DNA binding activity of recombinant AP-1, and 4) increased MCP-1 production in the liver correlates to the serum MCP-1 level in hyperhomocysteinemic rats.…”

Section: Discussionmentioning

confidence: 99%

Homocysteine Induces Monocyte Chemoattractant Protein-1 Expression in Hepatocytes Mediated via Activator Protein-1 Activation

Woo

Siow

Karmin

2008

Journal of Biological Chemistry

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Section: Discussionmentioning

confidence: 99%

Homocysteine Induces Monocyte Chemoattractant Protein-1 Expression in Hepatocytes Mediated via Activator Protein-1 Activation

Woo

Siow

Karmin

2008

Journal of Biological Chemistry

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Cardiovascular involvement after liver transplantation: role of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis

Lombardi

Pisano

Fracanzani

2021

Exploration of Medicine

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Patients submitted to liver transplantation (LT) are exposed to high risk of cardiovascular (CV) complications which are the main determinants of both short-term and long-term morbidity and mortality in LT. Non-alcoholic fatty liver disease (NAFLD) is a very frequent condition in general population and is associated with a high risk of cardiovascular disease (CVD) which represents the first cause of death of these patients. NAFLD is predicted to become the first indication to LT and nowadays is also frequently detected in patients submitted to LT for other indications. Thus, the risk of CVD in patients submitted to LT is forecasted to increase in the next years. In this review the extent of CV involvement in patients submitted to LT and the role of NAFLD, either recurring after transplantation or as de novo presentation, in increasing CV risk is analysed. The risk of developing metabolic alterations, including diabetes, hypertension, dyslipidemia and weight gain, all manifestations of metabolic syndrome, occurring in the first months after LT, is depicted. The different presentations of cardiac involvement, represented by early atherosclerosis, coronary artery disease, heart failure and arrhythmias in patients with NAFLD submitted to LT is described. In addition, the tools to detect cardiac alterations either before or after LT is reported providing the possibility for an early diagnosis of CVD and an early therapy able to reduce morbidity and mortality for these diseases. The need for long-term concerted multidisciplinary activity with dietary counseling and exercise combined with drug treatment of all manifestations of metabolic syndrome is emphasized.

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W09.210 Non-alcoholic fatty liver disease is associated with preclinical carotid atherosclerosis. A case-control study

Cited by 2 publications

References 0 publications

Homocysteine Induces Monocyte Chemoattractant Protein-1 Expression in Hepatocytes Mediated via Activator Protein-1 Activation

Homocysteine Induces Monocyte Chemoattractant Protein-1 Expression in Hepatocytes Mediated via Activator Protein-1 Activation

Cardiovascular involvement after liver transplantation: role of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis

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