Warty dyskeratoma of the oral mucosa

Newland, J R; Leventon, George

doi:10.1016/0030-4220(84)90134-8

Cited by 8 publications

(7 citation statements)

References 19 publications

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“…Study characteristics: US reported the highest number of cases (34 cases) [1,5,[9][10][11][12][13][14][15]18,[21][22][23][24][25][26]29], followed by UK (three cases) [4,19,20], Korea (two cases) [16,17], Australia (two cases) [28], Greece (one case) [27], and Israel (one case) [2].…”

Section: Resultsmentioning

confidence: 99%

“…Site of occurrence: The most common sites of occurrence were the masticatory mucosa including the alveolar ridge mucosa (11 cases) [1,12,[21][22][23]25,28], gingiva (eight cases) [10,14,18,22,29], hard palate (seven cases) [5,11,20,22,23], palatal mucosa (three cases) [9,24,27] followed by the lining mucosa including buccal mucosa (four cases) [2,11,19,22], soft palate (three cases) [22,26], lower lip (three cases) [15,22], upper lip (two cases) [16,17], soft palate-hard palate junction (one case) [22], lateral border of the tongue (one case) [18] and the floor of the mouth (one case) [4].…”

Section: Resultsmentioning

confidence: 99%

“…The cleft itself contained acantholytic cells which had a varying degree of dyskeratosis. The characteristic corps ronds and grains were also described in a few cases [2,5,[11][12][13]15,17,20,21,24,27,28]. The surface epithelium showed a cup-shaped depression corresponding to the areas clinically described as ulceration, sinus opening, depressed umbilicated centre, crater, and cavitation.…”

Section: -Year Follow-up Did Not Reveal Any Recurrencementioning

confidence: 88%

“…Additional investigations: Feulgen-Schiff stain and electron microscopy examination [21,24] did not reveal any viral, parasitic, or bacterial inclusions. Immunofluorescence showed basement membrane positivity for complement 3, albumin, and fibrinogen [10].…”

Section: -Year Follow-up Did Not Reveal Any Recurrencementioning

confidence: 96%

“…In such cases, the presence of the viral particles in the squamous papilloma lesion would be a distinguishing factor [33]. Electron microscopic studies have confirmed the absence of viral particles in OWK, although the data are based on only two included studies [21,24]. Warty dyskeratoma from extra-oral sites has also been shown to be negative for viral (human papillomavirus) DNA [34].…”

Section: S Nomentioning

confidence: 99%

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Oral Warty Dyskeratoma—A Systematic Review of the Literature

et al. 2022

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Objective: To systematically review the clinicopathological features of oral warty keratoma based on published literature. Materials and Methods: PubMed and Scopus databases were searched for reports of oral warty dyskeratoma. Of the 52 identified articles, only 25 articles (43 cases) satisfied the selection criteria (case report/series in the English language reporting clinicopathologically diagnosed oral warty dyskeratoma/oral focal acantholytic keratosis/oral isolated dyskeratosis follicularis in humans). Risk of bias was assessed using the Joanna Briggs institute critical appraisal checklist for case reports and case series. Results: Most cases had well-circumscribed, white, nodular verruco-papillary lesions with a central depressed/crater-like area. Alveolar ridges were the most frequent sites of occurrence and tobacco was the most commonly associated risk factor. Histopathologically, the most pathognomonic feature was the supra-basal clefting. The cleft had dyskeratotic acantholytic cells (corps ronds, and grains). Below the cleft were projections of the connective tissue villi lined by basal cells. The basal cells in a few cases exhibited hyperplasia in the form of budding into the stroma, but epithelial dysplasia was not reported. The surface epithelium had crypts filled with keratin debris. Conclusion: Oral warty dyskeratoma is a rare solitary self-limiting benign entity, which due to its clinical and histopathological resemblance and associated habit history could be misdiagnosed as leukoplakia or carcinoma. None of the assessed articles provided molecular data, which in turn could be the reason for the lack of insight into the etiopathogenesis of this enigmatic lesion.

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