Water driven transformation of a nonionic microemulsion into liquid crystalline phase: Structural characterizations and drug release behavior

Gandhi, Sonam M.; Khan, Aslam K.; Rathod, Sachin; Jain, Rupesh; Dubey, Sunil Kumar; Ray, Debes; Aswal, Vinod K.; Joshi, Amita; Bahadur, Pratap; Tiwari, Sanjay

doi:10.1016/j.molliq.2020.115239

Cited by 7 publications

(4 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Span-80 and Cremophor EL are also commonly used as surfactants for ME. The mixture of Span-80 and α-tocopheryl polyethylene glycol succinate (TPGS) as a surfactant could improve the in vitro release behavior of paclitaxel ( Gandhi et al, 2021 ). Cremophor EL was used to prepare ME for investigating the effects on human blood components and coagulation function ( Zhang et al, 2019 ).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Preparation, in vitro and in vivo evaluation of a novel mitiglinide microemulsions

Wang,

Li,

Yang

2024

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

“…Using Capryol 90 or Maisine 35-1 as the oil phase and Span-80 as the surfactant, ME could not form. It is reported that Span-80 always combines other surfactant to prepare ME ( Gandhi et al, 2021 , Ghorbanzadeh et al, 2019 ). Thus, Cremophor EL was chosen as surfactant due to its good solubility for MTG.…”

Section: Resultsmentioning

confidence: 99%

Preparation, in vitro and in vivo evaluation of a novel mitiglinide microemulsions

Wang,

Li,

Yang

2024

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

“…The DDLN gel was measured with an angular frequency range from 0.1 to 100 rad/s. G ′, G ″, and complex viscosity are the parameters evaluated by the frequency sweep test …”

Section: Methodsmentioning

confidence: 99%

“…G′, G″, and complex viscosity are the parameters evaluated by the frequency sweep test. 27 2.5.2. Texture Analysis.…”

Section: Amplitude Sweep Test and Frequency Sweepmentioning

confidence: 99%

Dual-Drug-Loaded Topical Delivery of Photodynamically Active Lipid-Based Formulation for Combination Therapy of Cutaneous Melanoma

et al. 2023

Self Cite

View full text Add to dashboard Cite

Topical administration of anti-cancer drugs along with photodynamically active molecules is a non-invasive approach, which stands to be a promising modality for treating aggressive cutaneous melanomas with the added advantage of high patient compliance. However, the efficiency of delivering drugs topically is limited by several factors, such as penetration of the drug across skin layers at the tumor site and limited light penetrability. In this study, curcumin, an active anti-cancer agent, and chlorin e6, a photoactivable molecule, were encapsulated into lipidic nanoparticles that produced reactive oxygen species (ROS) when activated at 665 nm by near-infrared (NIR) light. The optimized lipidic nanoparticle containing curcumin and chlorin e6 exhibited a particle size of less than 100 nm. The entrapment efficiency for both molecules was found to be 81%. The therapeutic efficacy of the developed formulation was tested on B16F10 and A431 cell lines via cytotoxicity evaluation, combination index, cellular uptake, nuclear staining, DNA fragmentation, ROS generation, apoptosis, and cell cycle assays under NIR irradiation (665 nm). Co-delivering curcumin and chlorin e6 exhibited higher cellular uptake, better cancer growth inhibition, and pronounced apoptotic events compared to the formulation having the free drug alone. The study results depicted that topical application of this ROS-generating dual-drug-loaded lipidic nanoparticles incorporated in SEPINEO gel achieved better permeation (80 ± 2.45%) across the skin, and exhibited the improved skin retention and a synergistic effect as well. The present work introduces photo-triggered ROS-generating dual-drug-based lipidic nanoparticles, which are simple and efficient to develop and exhibit synergistic therapeutic effects against cutaneous melanoma.

show abstract

Investigations on the role of edge activator upon structural transitions in Span vesicles

Rathod

Arya

Shukla

et al. 2021

Colloids and Surfaces A: Physicochemical and Engineering Aspect

View full text Add to dashboard Cite

Water driven transformation of a nonionic microemulsion into liquid crystalline phase: Structural characterizations and drug release behavior

Cited by 7 publications

References 36 publications

Preparation, in vitro and in vivo evaluation of a novel mitiglinide microemulsions

Preparation, in vitro and in vivo evaluation of a novel mitiglinide microemulsions

Dual-Drug-Loaded Topical Delivery of Photodynamically Active Lipid-Based Formulation for Combination Therapy of Cutaneous Melanoma

Investigations on the role of edge activator upon structural transitions in Span vesicles

Contact Info

Product

Resources

About