Water equivalent <scp>PRESAGE</scp><sup>®</sup> for synchrotron radiation therapy dosimetry

Gagliardi, Frank; Day, Liam; Poole, Christopher; Franich, Rick; Geso, Moshi

doi:10.1002/mp.12745

Cited by 7 publications

(10 citation statements)

References 23 publications

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“…The addition of DBTDL to this formulation also alters the Z eff of the PRESAGE dosimeter to be radiologically equivalent to water over a wide range of X-ray energies (Alqathami et al, 2015). Calculation of Z eff for this formulation of PRESAGE matches the Z eff of water within 1.7% over the effective energy range of 10 keV to 10 MeV (Gagliardi et al, 2018a).…”

Section: Nanoparticle Presage Dosimeter Fabricationmentioning

confidence: 99%

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Nanoparticle dose enhancement of synchrotron radiation in PRESAGE dosimeters

Gagliardi

Franich

Geso

2020

J Synchrotron Radiat

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The physical absorbed dose enhancement by the inclusion of gold and bismuth nanoparticles fabricated into water-equivalent PRESAGE dosimeters was investigated. Nanoparticle-loaded water-equivalent PRESAGE dosimeters were irradiated with superficial, synchrotron and megavoltage X-ray beams. The change in optical density of the dosimeters was measured using UV–Vis spectrophotometry pre- and post-irradiation using a wavelength of 630 nm. Dose enhancement was measured for 5 nm and 50 nm monodispersed gold nanoparticles, 5–50 nm polydispersed bismuth nanoparticles, and 80 nm monodispersed bismuth nanoparticles at concentrations from 0.25 mM to 2 mM. The dose enhancement was highest for the 95.3 keV mean energy synchrotron beam (16–32%) followed by the 150 kVp superficial beam (12–21%) then the 6 MV beam (2–5%). The bismuth nanoparticle-loaded dosimeters produced a larger dose enhancement than the gold nanoparticle-loaded dosimeters in the synchrotron beam for the same concentration. For the superficial and megavoltage beams the dose enhancement was similar for both species of nanoparticles. The dose enhancement increased with nanoparticle concentration in the dosimeters; however, there was no observed nanoparticle size dependence on the dose enhancement.

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Section: Nanoparticle Presage Dosimeter Fabricationmentioning

confidence: 99%

“…Our previous investigations have demonstrated the radiological response of a water-equivalent (WE) PRESAGE over a range of X-ray energies (Gagliardi et al, 2018a) as well as the dose response and stability to synchrotron-generated X-rays (Gagliardi et al, 2018b).…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle dose enhancement of synchrotron radiation in PRESAGE dosimeters

Gagliardi

Franich

Geso

2020

J Synchrotron Radiat

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“…For a pair production cross-section, PRESAGE has a maximum difference of 9% when compared with the water [ 84 ]. A study shows that PRESAGE has a percentage difference within 2% in photon absorption as compared with water over an energy range of 10 keV to 10 MeV, due to the addition of DBTDL, which was able to modify the effective atomic number of PRESAGE [ 90 ].…”

Section: Radiological Properties Of Presagementioning

confidence: 99%

A Review of PRESAGE Radiochromic Polymer and the Compositions for Application in Radiotherapy Dosimetry

et al. 2022

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Recent advances in radiotherapy technology and techniques have allowed a highly conformal radiation to be delivered to the tumour target inside the body for cancer treatment. A three-dimensional (3D) dosimetry system is required to verify the accuracy of the complex treatment delivery. A 3D dosimeter based on the radiochromic response of a polymer towards ionising radiation has been introduced as the PRESAGE dosimeter. The polyurethane dosimeter matrix is combined with a leuco-dye and a free radical initiator, whose colour changes in proportion to the radiation dose. In the previous decade, PRESAGE gained improvement and enhancement as a 3D dosimeter. Notably, PRESAGE overcomes the limitations of its predecessors, the Fricke gel and the polymer gel dosimeters, which are challenging to fabricate and read out, sensitive to oxygen, and sensitive to diffusion. This article aims to review the characteristics of the radiochromic dosimeter and its clinical applications. The formulation of PRESAGE shows a delicate balance between the number of radical initiators, metal compounds, and catalysts to achieve stability, optimal sensitivity, and water equivalency. The applications of PRESAGE in advanced radiotherapy treatment verifications are also discussed.

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“…Through 61,62 It is reported in the literature by Gagliardi et al that water-equivalent PRESAGE® is well suited for high-resolution 3D imaging of synchrotron-generated micro beams in stereotactic synchrotron radiotherapy (SSRT). 63 Gagliardi et al have investigated in their other exploration about the validation of the radiological response of water equivalent PRESAGE in 3D dosimetry for synchrotron X-ray photon energies. PRESAGE® was shaped into cylindrical rods with 70 mm in length and 43 mm in width.…”

Section: Presage® Dosimetry In Stereotactic Synchrotron Radiotherapymentioning

confidence: 99%

“…PRESAGE® showed an inability to measure field penumbra, but PRESAGE® possesses the potential to determine dose profiles which were calculated by MC model and verified by EBT3 films in SSRT and microbeam radiotherapy (MRT). 63…”

Section: Presage® Dosimetry In Stereotactic Synchrotron Radiotherapymentioning

confidence: 99%

Review on the feasibility of using PRESAGE® dosimeter in various radiotherapy techniques

et al. 2020

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The emergence of advanced radiotherapy techniques, such as intensity-modulated radiotherapy (IMRT), brachytherapy, conformal radiotherapy, magnetic resonance-guided radiotherapy (MRgRT), stereotactic synchrotron radiotherapy (SSRT) and microbeam radiotherapy (MRT), has increased the importance of the verification of volumetric dose distribution. The verification of dose distribution is usually done by 2D films and 3D gel dosimeters, but PRESAGE® due to its affordability, reproducibility, precision, accuracy, unique dosimetric and physical properties is considered as an effective candidate in providing 3D dose data. PRESAGE® is insensitive to oxygen contamination, machinable and can be molded to a variety of shapes and sizes. It is absorbing rather than scattering light which facilitates high-accuracy readout by optical computed tomography (OP-CT). This review focuses on the feasibility of using PRESAGE® in various complicated radiotherapy techniques by comparing its measured doses with 2D films and treatment planning system (TPS) calculated doses.

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Water equivalent PRESAGE^® for synchrotron radiation therapy dosimetry

Abstract: The radiological response of a water equivalent PRESAGE dosimeter has been validated for synchrotron x-ray beam energies along with the ability to independently verify dose distributions of a MC model.

Cited by 7 publications

References 23 publications

Nanoparticle dose enhancement of synchrotron radiation in PRESAGE dosimeters

Nanoparticle dose enhancement of synchrotron radiation in PRESAGE dosimeters

A Review of PRESAGE Radiochromic Polymer and the Compositions for Application in Radiotherapy Dosimetry

Review on the feasibility of using PRESAGE® dosimeter in various radiotherapy techniques

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Water equivalent PRESAGE® for synchrotron radiation therapy dosimetry

Abstract: The radiological response of a water equivalent PRESAGE dosimeter has been validated for synchrotron x-ray beam energies along with the ability to independently verify dose distributions of a MC model.

Cited by 7 publications

References 23 publications

Nanoparticle dose enhancement of synchrotron radiation in PRESAGE dosimeters

Nanoparticle dose enhancement of synchrotron radiation in PRESAGE dosimeters

A Review of PRESAGE Radiochromic Polymer and the Compositions for Application in Radiotherapy Dosimetry

Review on the feasibility of using PRESAGE® dosimeter in various radiotherapy techniques

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Product

Resources

About

Water equivalent PRESAGE^® for synchrotron radiation therapy dosimetry