Water / Methyl isobutyl ketone (MIBK) Biphasic System in Slug Flow under High Temperature and Pressure Conditions

Abstract

The clarification of the partition property of substrates in a water / organic biphasic system is useful in the development of a reaction / separation process for value-added materials, especially under high temperature and pressure conditions. In this study, the water / methyl isobuthyl ketone (MIBK) biphasic system was investigated under various temperatures (25 -190 o C) at 10 MPa. The partitioning behavior of substrates such as furfural derivatives, amino acids, and saccharides, depended on the temperature and the flow rate ratio of MIBK to the water phase. The scale of hydrophobicity (HF) of the water / MIBK biphasic system to determine the partitioning behavior of substrates was estimated based on the partitioning behavior of amino acids. The HF value for the water / MIBK phase flow system of was greater than that for the batch system and comparable to that for conventional aqueous two-phase systems such as polyethylene glycol / dextran and liposome membrane systems. It was probably because an increase of the surface-to-volume ratio and the vortex field in the slug flow contributed to the mass transfer of substrates and their distribution.

Chemical conversion and liquid–liquid extraction of 5‐hydroxymethylfurfural from fructose by slug flow microreactor

“…We assumed the slug flow with the wall film in the tube, as shown in Figure b. This is because the slug flow was observed under low temperature conditions, as previously reported . Assuming a linear driving force approximation as previous reported, the mass transfer rate of HMF from the aqueous to the organic phase can be described.…”

“…In our previous study, it has been reported that a liquid–liquid slug flow of water/methyl isobuthyl ketone (MIBK) biphasic system in T‐junction microcapillary was advantageous for the reaction of fructose to HMF in comparison of reactor type between the batch and flow systems . Likewise, the above slug flow had the enhanced mass transfer of 17 kinds of compounds from water to MIBK phase . We have developed the reaction kinetic model taking into consideration of the mass transfer for HMF between water and organic phases, and there is lack of investigations relating to the mass transfer of HMF and the fluid dynamics in slug flow.…”

“…This model can describe the mass transfer of HMF between two‐phase and several parameters are required. For the reason, we determined kinetic parameters in the reaction of fructose to HMF in the batch aqueous system (not a two‐phase system), and the apparent partition coefficient of HMF in water/MIBK biphasic system, according to the previous report . Afterwards, the reactivity and selectivity of the target reaction were investigated as a function of velocity and the flow rate, which were used to compute the mass transfer of HMF in a water/MIBK biphasic system.…”

“…Afterwards, the reactivity and selectivity of the target reaction were investigated as a function of velocity and the flow rate, which were used to compute the mass transfer of HMF in a water/MIBK biphasic system. Finally, we discussed how the mass transfer of HMF in the reaction achieved the optimization of reactivity and how the enhancement of mass transfer of HMF related to the velocity field generated in the slug flow, according to the previous method …”

Single stage and countercurrent extraction of 5-hydroxymethylfurfural from aqueous phase systems

“…Furthermore, it has low hazardousness and already gave promising results in previous publications [3,[10][11][12][13][14][15][16][17]. Other applied solvents are ethyl acetate and 2-heptanone which have similar abilities to dissolve 5-HMF.…”