Water-soluble chiral monosulfonamide-cyclohexane-1,2-diamine-RhCp∗ complex and its application in the asymmetric transfer hydrogenation (ATH) of ketones

Ruthenium-catalysed asymmetric transfer hydrogenation of para-substituted α-fluoroacetophenones

“…Generally, the highest rates were observed in reductions using catalyst 5, while catalyst 6 gave the longest reaction times. As expected, the ketones substituted with electron donating substituents tended to react slower than their more electron deficient counterparts [18]. Observed differences in conversion could also be due to the low solubility and crystalline nature of several of the a-fluoroacetophenones in water.…”

“…Numerous investigations on the effects of different catalysts, metal species, solvent systems, additives, temperature and pH on the rate and selectivity of asymmetric transfer hydrogenations have been reported [7,9,10,[13][14][15][16][17][18][19][20][21].…”

Synthesis of New Chiral Monosulfonamides Prepared from (11R,12R)-11,12-Diamino-9,10-dihydro-9,10-ethanoanthracene and their Use as Ligands for Asymmetric Catalysis

“…Somanathan et al [17][18] reported the use of monosulfonamide ligand 3a-b, derived from trans-(1R,2R)-cyclohexane-1,2-diamine, in the asymmetric transfer hydrogenation of aromatic ketones. Enantioselectivities ranged from 70 to 99% and good yields for the synthesis of 1-phenylpropanol derivatives were achieved.…”

Catalytic Asymmetric Transfer Hydrogenation of Ketones Using [Ru(p-cymene)Cl2]2 with Chiral Amino Alcohol Ligands

“…The advantages of asymmetric transfer hydrogenation using 2-propanol as a reductant are well documented in the literature [5,9,10]. Owing to simplicity of operation and importance of the subject, the reaction has been extensively investigated using various ligands and hydrogen sources in recent years [11][12][13][14][15]. One of the most significant breakthroughs in transfer hydrogenation was reported by Noyori et al with the use of chlororuthenium (II) arene precursors with chiral monoarylsulfonylated-1,2-diamines [16][17][18] or b-amino alcohols [19] as ligands.…”