2013
DOI: 10.15835/nbha4129305
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Water Soluble <i>Pleurotus ostreatus</i> Polysaccharide Down-Regulates the Expression of MMP-2 and MMP-9 in Caco-2 Cells

Abstract: Many polysaccharides and polysaccharide-protein complexes isolated from mushrooms have immunomodulatory and anti-cancer effects. Our aim was to study the regulatory mechanisms of Caco-2 cell response to water soluble P. ostreatus polysaccharide extract up to 72 hours. Specific enzymatic activities were assessed by kinetic measurements. The reduced glutathione content and the lipid peroxidation level were also analyzed. Protein expression of several heat shock proteins, Bcl-2 and metalloproteinases 2 and 9 were… Show more

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Cited by 5 publications
(2 citation statements)
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“…This is thought to be correlated with GSH levels whose results are the opposite of MDA levels, on the same day. 42 In vitro test of ethanolic extract P. ostreatus has a potent reducing power and this effect increases with increasing extract concentration. The reduction ability at 10 mg/mL is 1.367, which is better than BHT (1,192).…”
Section: Discussionmentioning
confidence: 99%
“…This is thought to be correlated with GSH levels whose results are the opposite of MDA levels, on the same day. 42 In vitro test of ethanolic extract P. ostreatus has a potent reducing power and this effect increases with increasing extract concentration. The reduction ability at 10 mg/mL is 1.367, which is better than BHT (1,192).…”
Section: Discussionmentioning
confidence: 99%
“…This is thought to be correlated with GSH levels whose results are the opposite of MDA levels, on the same day. 42 In vitro test of ethanol extract P. ostreatus has a potent reducing power and this effect increases with increasing extract concentration. The reduction ability at 10 mg/mL is 1.367, which is better than BHT (1,192).…”
Section: Discussionmentioning
confidence: 99%