Water-soluble polymer micelles formed from amphiphilic diblock copolymers bearing pendant phosphorylcholine and methoxyethyl groups

Tsuji, Alisa; Nguyen, Thi Hoai Thu; Mizoue, Yoko; Ishihara, Kazuhíko; Yusa, Shin‐ichi

doi:10.1038/s41428-021-00482-2

Cited by 8 publications

(11 citation statements)

References 52 publications

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“…The NPA may induce failures in the delivery of therapeutic agents to the desired target sites, leading to drug degradation, cell toxicity, and unexpected side reactions. To resolve the problem, copolymers composed of MPC able to suppress NPA and other moieties allowing encapsulation, delivery and controlled release of therapeutic agents have been developed to form many kinds of drug carrier structures such as nanoparticles (NPs), [115][116][117][118][119][120][121] dendrimers, 122,123 micelles, [124][125][126][127][128][129] polymersomes, [130][131][132] and liposomes 9,132,133 on micrometer to nanometer scales. The characteristics of the MPC moiety in MPC copolymers to suppress NPA can play a critical role in the improvement of the biocompatibility of the DDS by increasing blood circulation time, enhancing specific binding to the targeted cells, avoiding immune recognition and elimination, and reducing cell toxicity.…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

Recent progress and perspectives in applications of 2-methacryloyloxyethyl phosphorylcholine polymers in biodevices at small scales

Seetasang

2022

J. Mater. Chem. B

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Section: Drug Delivery Systemsmentioning

confidence: 99%

Recent progress and perspectives in applications of 2-methacryloyloxyethyl phosphorylcholine polymers in biodevices at small scales

Seetasang

2022

J. Mater. Chem. B

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“…It is reported to remain in an active state in many malignant tumors due to overexpression. , HA-based conjugates are suitable for active targeting of CD44-bearing receptors on the surface of necrotic cells and passive targeting of tumors via the enhanced permeability and retention (EPR) effect. CD44-mediated antitumor medications specifically target tumor cells while reducing traditional anticancer drug toxicity and side effects on normal cells. , Based on this belief, HA-based targeted formulations have been thoroughly researched for CD44 receptor overexpressed tumor treatments. Several reports suggest that redox-sensitive targeted drug delivery could be of immense application for delivering drugs with low toxicity.…”

Section: Introductionmentioning

confidence: 99%

“…CD44-mediated antitumor medications specifically target tumor cells while reducing traditional anticancer drug toxicity and side effects on normal cells. 26,27 Based on this belief, HA-based targeted formulations have been thoroughly researched for CD44 receptor overexpressed tumor treatments. Several reports suggest that redox-sensitive targeted drug delivery could be of immense application for delivering drugs with low toxicity.…”

Section: Introductionmentioning

confidence: 99%

Self-Assembled Redox-Sensitive Polymeric Nanostructures Facilitate the Intracellular Delivery of Paclitaxel for Improved Breast Cancer Therapy

et al. 2023

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A two-tier approach has been proposed for targeted and synergistic combination therapy against metastatic breast cancer. First, it comprises the development of a paclitaxel (PX)-loaded redox-sensitive self-assembled micellar system using betulinic acid–disulfide–d-α-tocopheryl poly(ethylene glycol) succinate (BA-Cys-T) through carbonyl diimidazole (CDI) coupling chemistry. Second, hyaluronic acid is anchored to TPGS (HA-Cys-T) chemically through a cystamine spacer to achieve CD44 receptor-mediated targeting. We have established that there is significant synergy between PX and BA with a combination index of 0.27 at a molar ratio of 1:5. An integrated system comprising both BA-Cys-T and HA-Cys-T (PX/BA-Cys-T-HA) exhibited significantly higher uptake than PX/BA-Cys-T, indicating preferential CD44-mediated uptake along with the rapid release of drugs in response to higher glutathione concentrations. Significantly higher apoptosis (42.89%) was observed with PX/BA-Cys-T-HA than those with BA-Cys-T (12.78%) and PX/BA-Cys-T (33.38%). In addition, PX/BA-Cys-T-HA showed remarkable enhancement in the cell cycle arrest, improved depolarization of the mitochondrial membrane potential, and induced excessive generation of ROS when tested in the MDA-MB-231 cell line. An in vivo administration of targeted micelles showed improved pharmacokinetic parameters and significant tumor growth inhibition in 4T1-induced tumor-bearing BALB/c mice. Overall, the study indicates a potential role of PX/BA-Cys-T-HA in achieving both temporal and spatial targeting against metastatic breast cancer.

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“…This is due to the restriction of the movement of the poly(MEA) moieties and indicates the formation of the core by PMEA. 39 After RAFT-PISA, the reaction mixture was dialyzed against water and then methanol to obtain the dispersion of bare micelles in methanol. The spherical morphology of the bare micelle was confirmed via transmission electron microscopy (TEM) with a staining agent (uranyl acetate, Figure S7).…”

Section: ■ Introductionmentioning

confidence: 99%

Molecular Insights into Photochemical Hydrogen Evolution Dual Catalysis within the Shell of Polymer Micelle-Based Nanoreactors

Enomoto

Tsuji

et al. 2023

ACS Appl. Nano Mater.

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Polymer micelles are promising candidates for facilitating efficient catalysis within their distinguished nanospaces. However, the design of polymer micelle-based nanoreactors for dual photocatalysis, where a photocatalyst and another catalyst are involved in a single catalysis, remains limited in scope due to the lack of molecular insight into the bimolecular process within polymer micelles. Here, we investigated the cooperativity of a photocatalyst and a hydrogen evolution catalyst immobilized within the shell of polymer micelle-based nanoreactors. The results of several photochemical experiments suggested the existence of two types of catalyst pairs, the fluctuated and contacted pairs of the photocatalyst and hydrogen evolution catalyst within the nanoreactors. Moreover, the reaction rates of the photochemical hydrogen evolution were strongly affected by molecular crowding within the shell. Our study paves the way for developing polymer micelle-based nanoreactors for efficient dual photocatalysis.

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Water-soluble polymer micelles formed from amphiphilic diblock copolymers bearing pendant phosphorylcholine and methoxyethyl groups

Cited by 8 publications

References 52 publications

Recent progress and perspectives in applications of 2-methacryloyloxyethyl phosphorylcholine polymers in biodevices at small scales

Recent progress and perspectives in applications of 2-methacryloyloxyethyl phosphorylcholine polymers in biodevices at small scales

Self-Assembled Redox-Sensitive Polymeric Nanostructures Facilitate the Intracellular Delivery of Paclitaxel for Improved Breast Cancer Therapy

Molecular Insights into Photochemical Hydrogen Evolution Dual Catalysis within the Shell of Polymer Micelle-Based Nanoreactors

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