Water-Stable, Adaptive, and Electroactive Supramolecular Ionic Material and Its Application in Biosensing

Zhang, Li; Qi, Hetong; Hao, Jie; Yang, Lei; Yu, Ping; Mao, Lanqun

doi:10.1021/am5011628

Cited by 8 publications

(12 citation statements)

References 47 publications

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“…According to our earlier work, the SIM was synthesized by mixing an aqueous solution of the hydroxide-exchanged form of C 10 (mim) 2 (2 mM) with an equal amount of ABTS (2 mM) under stirring for 2 h at room temperature to produce a white precipitate. The precipitate was washed several times with doubly distilled water, collected by centrifugation, and dried in a vacuum drying oven.…”

Section: Methodsmentioning

confidence: 99%

“…Motivated by this need, we are interested in preparing water-stable supramolecular ionic materials by ionic self-assembly from an aqueous medium. − Our previous attempts have revealed that water-stable supramolecular ionic materials (SIMs) based on an imidazolium-based dication (e.g., 1,10-bis(3-methylimidazolium-1-yl) decane, C 10 (mim) 2 ) and electroactive dianionic (e.g., 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), ABTS) with good water stability, adaptive encapsulation capability and solvent stimuli-responsive properties can be prepared . Interestingly, herein, we find that solid-state supramolecular materials created via ionic self-assembly show humidity-dependent conductivity.…”

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confidence: 99%

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Sensitive and Fast Humidity Sensor Based on A Redox Conducting Supramolecular Ionic Material for Respiration Monitoring

Yan

Zhang

et al. 2016

Anal. Chem.

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Real-time monitoring of respiratory rate (RR) is highly important for human health, clinical diagnosis, and fundamental scientific research. Exhaled humidity-based RR monitoring has recently attracted increased attention because of its accuracy and portability. Here, we report a new design of an exhaled humidity sensor for the real-time monitoring of the RR based on a synthetic redox conducting supramolecular ionic material (SIM). The humidity-dependent conducting SIM is prepared by ionic self-assembly in aqueous solutions of electroactive 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 1,10-bis(3-methylimidazolium-1-yl) decane (C(mim)). By taking full advantage of the high hygroscopicity and water stability arising from the ionic and hydrophobic interactions between two building blocks (i.e., ABTS and C(mim)), the SIM-based humidity sensor exhibits both high sensitivity (less than 0.1% relative humidity) and fast response time (∼37 ms). These excellent properties allow this humidity sensor to noninvasively monitor the RRs of not only humans but also rats that have a much faster RR and much smaller tidal volume than humans. Moreover, this sensor could also be efficiently used for the real-time monitoring of the recovery process of rats from anesthesia.

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Section: Methodsmentioning

confidence: 99%

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confidence: 99%

Sensitive and Fast Humidity Sensor Based on A Redox Conducting Supramolecular Ionic Material for Respiration Monitoring

Yan

Zhang

et al. 2016

Anal. Chem.

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“…10A). 46,47 The formed SIMs not only show good thermostability and unique optical/electrochemical properties that are originated from the precursors of the SIM, but also exhibit good water-stability, salt-stability, and adaptive encapsulation properties toward some heterocyclic cationic dye molecules. These unique properties essentially made the materials particularly attractive for chem/(bio)sensor development.…”

Section: Interionic Interaction For Sensing Materials Preparationmentioning

confidence: 99%

“…For example, by encapsulating electroactive molecules (e.g., methylene green, MG) into the materials through the interionic interaction between MG and the anionic building blocker (i.e., ABTS), an electrochemical sensor for NADH was developed at a low potential of À0.07 V (vs. Ag/AgCl). 46 Again, by encapsulating optically active rhodamine 6G into the materials, a visualization assay was successfully established for on-the-spot and fast sensing of alcohol using thin-layer chromatography. 48 As shown in Fig.…”

Section: Interionic Interaction For Sensing Materials Preparationmentioning

confidence: 99%

Tuning interionic interaction for highly selective in vivo analysis

Mao

2015

Chem. Soc. Rev.

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The development of highly selective methodologies to enable in vivo recording of chemical signals is of great importance for studying brain functions and brain activity mapping. However, the complexity of cerebral systems presents a great challenge in the development of chem/(bio)sensors that are capable of directly and selectively recording bioactive molecules involved in brain functions. As one of the most important and popular interactions in nature, interionic interaction constitutes the chemical essence of high specificity in natural systems, which inspires us to develop highly selective chem/(bio)sensors for in vivo analysis by precisely engineering interionic interaction in the in vivo sensing system. In this tutorial review, we focus on the recent progress in the tuning of interionic interaction to improve the selectivity of biosensors for in vivo analysis. The type and property of the interionic interaction is first introduced and several strategies to improve the selectivity of the biosensors, including enzyme-based electrochemical biosensors, aptamer-based electrochemical biosensors, and the strategies to recruit recognition molecules are reviewed. We also present an overview of the potential applications of the biosensors for in vivo analysis and thereby for physiological investigations. Finally, we present the major challenges and opportunities regarding the high selectivity of in vivo analysis based on tuning interionic interaction. We believe that this tutorial review provides critical insights for highly selective in vivo analysis and offers new concepts and strategies to understand brain chemistry.

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“…In biosensor development, this characteristic can be of great importance [48]. Recently, Zhang et al [49] reported a biosensor based on an adaptive material composed by an electro-active supramolecular ionic material of imidazolium di-cation and di-anionic dyes. These compounds self-assemble, resulting in a structure with unique optical and electrochemical properties and adaptive encapsulation properties in the presence of cationic dyes.…”

Section: Supramolecular Compounds For Optical Biosensorsmentioning

confidence: 99%

Supramolecular Materials for Optical and Electrochemical Biosensors

Martins¹,

Ribeiro²,

FlavioColmati³

et al. 2015

Biosensors - Micro and Nanoscale Applications

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It is incontestable that the interactions and bonds that keep molecules united to generate unique supramolecular compounds, with individual properties, morphologies and behaviour, are of special dynamics and singular forces. Therefore, it is necessary to discuss and consider the types of interactions that may occur in a determined system, their dynamics and number, which directly act on the energetic balance that strengthen the union between participants and give rise to a supramolecule.In this chapter, a number of such supramolecular systems that find application as any component of a biosensor are presented and discussed, considering intermolecular interaction forces that confer them shape, function and unique properties. To better understand their structural dynamics and the mechanisms through which they can be used in biosensing, a brief explanation on the interaction thermodynamics, types of intermolecular interactions that compete against each other and the energetic equilibrium that originate and stabilize supramolecular systems is given. To explain how this balance of forces can be extensively exploited to develop methods to produce supramolecular compounds, an overview on supramolecular strategies is presented and their contribution is explored in each example presented in this text, to evidence the importance of planning and developing methodologies of preparation, based on

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Water-Stable, Adaptive, and Electroactive Supramolecular Ionic Material and Its Application in Biosensing

Cited by 8 publications

References 47 publications

Sensitive and Fast Humidity Sensor Based on A Redox Conducting Supramolecular Ionic Material for Respiration Monitoring

Sensitive and Fast Humidity Sensor Based on A Redox Conducting Supramolecular Ionic Material for Respiration Monitoring

Tuning interionic interaction for highly selective in vivo analysis

Supramolecular Materials for Optical and Electrochemical Biosensors

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