Wavelength dependency for UVA-induced suppression of recall immunity in humans

The suppressive effects of ultraviolet radiation on immunity in the skin and internal organs: Implications for autoimmunity

“…While 290-310 nm UVB was immunosupppressive in humans [10], shortwavelength UVA between 320 and 350 nm did not suppress immunity. However longwave UVA from 364 to 385 nm UVA was potently immuosuppressive [11]. Therefore we found 2 distinct non-overlapping regions within the UV spectrum that suppressed immunity in humans [12].…”

“…The action spectrum for solar immune suppressive effectiveness in humans has two peaks centred at 310 and 370 nm. Solar effectiveness was determined by multiplying data for UV-induced immunosuppression at different wavelengths [10,11] by the standard noon solar spectrum (black circles) (Colipa). The data were curve fitted to a Gaussian distribution (black line).…”

18-årsgrensen for solariebruk skal håndheves

“…The effects are dose dependent. The immunosuppressive effect of (narrow-band) UVA was apparent at doses in the range 300 to 1000 mJ/cm 2 ; this effect of UVA disappeared at higher doses (Matthews et al, 2010, Damian et al, 2011. Studies in mice showed for UVA a photoimmune protective effect on immunosuppression (Reeve et al, 2009).…”

UVA-induced protection of skin through the induction of heme oxygenase-1

“…The wide spectral waveband of UVA (320-400 nm) could react with different chromophores in skin, leading to different effects on the immune system of skin (16). It was found that pretreatment with UVA1 (340-400 nm) may offer partial protection against UVB-induced decrease of immunization reaction to epidermis allergens (17).…”