Weakened foreign body response to medical polyureaurethane treated by plasma immersion ion implantation

Chudinov, V. S.; Kondyurina, Irina; Terpugov, V. N.; Kondyurin, Alexey

doi:10.1016/j.nimb.2018.12.026

Cited by 19 publications

(8 citation statements)

References 47 publications

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“…Measurements were performed at 30 points on the sample surface. The root-mean-square roughness value (RMS-roughness) was calculated using the following formula: 16, 78 9 of 13 where z i is the deviation of the height of the peak or the depth of the valley from the profile center line and where N is the number of measurements.…”

Section: Resultsmentioning

confidence: 99%

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Mechanical Properties of the Carbonized Layer Formed by Ion Flow Orientated at Different Angles to the Polyurethane Surface

Chudinov,

Shardakov,

Ivanov

et al. 2023

Polymers

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Polymer materials are widely used in medicine due to their mechanical properties and biological inertness. When ion-plasma treatment is used on a polymer material, a carbonization process occurs in the surface nanolayer of the polymer sample. As a result, a surface carbonized nanolayer is formed, which has mechanical properties different from those of the substrate. This layer has good biocompatibility. The formation of a carbonized nanolayer on the surface of polymer implants makes it possible to reduce the body’s reaction to a foreign body. Typically, to study the properties of a carbonized layer, flat polymer samples are used, which are treated with an ion flow perpendicular to the surface. But medical endoprostheses often have a curved surface, so ion-plasma treatment can occur at different angles to the surface. This paper presents the results of a study of the morphological and mechanical properties of a carbonized layer formed on a polyurethane surface. The dependence of these properties on the directional angle of the ion flow and its fluence has been established. To study the surface morphology and elastic properties, methods of atomic force microscopy and methods of elasticity theory were used. The strength properties of the carbonized layer were studied using a stretching device combined with a digital optical microscope.

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Section: Resultsmentioning

confidence: 99%

“…As a result of ion-plasma treatment, carbonization of the surface layer of the polymer occurs and a carbonized hydrophilic nanolayer is formed that is capable of covalently binding adsorbed proteins in the native conformation. This nanolayer has improved biocompatibility compared to the polymer substrate [ 14 , 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Mechanical Properties of the Carbonized Layer Formed by Ion Flow Orientated at Different Angles to the Polyurethane Surface

Chudinov,

Shardakov,

Ivanov

et al. 2023

Polymers

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show abstract

“…This phenomenon has also been found in applications in metrology [11], the development of smart materials [12], and flexible electronics [13]. However, the application of such materials is associated with mechanical loads that provoke the following defects in the treated surfaces: strain-induced cracks and folds [14][15][16][17]. Under cyclic loads, even tiny nanocracks propagate to a considerable depth [18], damaging both the polymer and the surrounding tissues; the formed defects become centers of bacterial growth [10].…”

Section: Introductionmentioning

confidence: 94%

Polyurethane Treated in Ar/C2H2/Ar Plasma: Towards Deformable Coating with Improved Albumin Adsorption

et al. 2021

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Plasma modification of soft polymeric surfaces has many prospects in creating biomedical devices. The deformability of the obtained coatings should be studied, as the usage of such materials implies mechanical loads. Polyurethane (a two-phase synthetic polymer) treated in argon/acetylene plasma, with post-treatment in argon plasma, was investigated. A carbon-containing nanocoating (discontinuous mesh-like structures) with structural–mechanical inhomogeneities is formed by the action of Ar/C2H2 plasma. The heterogeneities of the coating are due to the complex structure of the initial substrate and short duration of treatment; as the treatment time increases, the coatings become homogeneous, but their stiffness rises. The treated surfaces in the uniaxial tensile state have micro and/or nanocracks in certain cases of plasma treatment. This is associated with an increased elastic modulus of the coatings. The coatings without cracks have regions with sufficiently alternating stiffness. Post-treatment in argon plasma increases wettability and free surface energy, positively affecting the adsorption of albumin. The stiffness of such coatings increases, becoming more homogeneous, which slightly reduces their crack resistance. Thus, plasma coatings on soft polymers operating under mechanical loads without causing damage should have sufficiently low stiffness, and/or structural-mechanical heterogeneities that provide redistribution of stress.

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“…Для изменения свойств поверхности поливинилхлорида с целью улучшения его биосовместимости мы будем использовать метод плазменно-иммерсионной ионной имплантации [10][11]. С помощью данного метода воздействия высокоэнергетических ионов на полимерный материал на его поверхности формируется карбонизованный слой, содержащий полиароматические конденсированные структуры с неспаренными электронами, стабилизированными π-электронным облаком на границах графитоподобных кластеров [12][13][14]. Поверхность карбонизованного слоя характеризуется улучшенной смачиваемостью и адсорбционной активностью к белкам [15].…”

Section: для цитированияunclassified

Covalent immobilization of albumin on the surface of medical polyvinyl chloride modified by plasma-imersion ion implantation

Kondyurina,

McKenzie

2023

Perm Sci. Cent. J.

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Weakened foreign body response to medical polyureaurethane treated by plasma immersion ion implantation

Cited by 19 publications

References 47 publications

Mechanical Properties of the Carbonized Layer Formed by Ion Flow Orientated at Different Angles to the Polyurethane Surface

Mechanical Properties of the Carbonized Layer Formed by Ion Flow Orientated at Different Angles to the Polyurethane Surface

Polyurethane Treated in Ar/C2H2/Ar Plasma: Towards Deformable Coating with Improved Albumin Adsorption

Covalent immobilization of albumin on the surface of medical polyvinyl chloride modified by plasma-imersion ion implantation

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