Weaker Connectivity of the Cortical Networks Is Linked with the Uncharacteristic Gait in Youth with Cerebral Palsy

Doucet, Gaëlle E.; Baker, Sarah; Wilson, Tony W.; Kurz, Max J.

doi:10.3390/brainsci11081065

Cited by 9 publications

(6 citation statements)

References 63 publications

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“… 33 , 36–39 For example, our recent fMRI experimental work demonstrated decreased FC between motor and visual networks and connected these aberrations to altered gait kinematics. 40 Thus, resting-state paradigms provide a viable approach to assessing how the initial brain insult alters cortical networks and has cascading effects on the overall neurophysiology of CP.…”

Section: Introductionmentioning

confidence: 99%

Altered spontaneous cortical activity predicts pain perception in individuals with cerebral palsy

Trevarrow

Reelfs

Ott

et al. 2022

Brain Communications

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Cerebral palsy is the most common pediatric neurological disorder and results in extensive impairment to the sensorimotor system. However, these individuals also experience increased pain perception, resulting in decreased quality of life. In the current study, we utilized magnetoencephalographic brain imaging to examine whether alterations in spontaneous neural activity predict the level of pain experienced in a cohort of 38 individuals with spastic diplegic cerebral palsy and 67 neurotypical controls. Participants completed five minutes of an eyes closed resting-state paradigm while undergoing a magnetoencephalography recording. The magnetoencephalographic data were then source imaged, and the power within the delta (2–4 Hz), theta (5–7 Hz), alpha (8–12 Hz), beta (15–29 Hz), low gamma (30–59 Hz), and high gamma (60–90 Hz) frequency bands were computed. The resulting power spectral density maps were analyzed vertex-wise to identify differences in spontaneous activity between groups. Our findings indicated that spontaneous cortical activity was altered in the participants with cerebral palsy in the delta, alpha, beta, low gamma, and high gamma bands across the occipital, frontal, and secondary somatosensory cortical areas (all pFWE < 0.05). Furthermore, we also found that the altered beta band spontaneous activity in the secondary somatosensory cortices predicted heightened pain perception in the individuals with cerebral palsy (p = 0.039). Overall, these results demonstrate that spontaneous cortical activity within individuals with cerebral palsy is altered in comparison to their neurotypical peers and may predict increased pain perception in this patient population. Potentially, changes in spontaneous resting-state activity may be utilized to measure the effectiveness of current treatment approaches that are directed at reducing the pain experienced by individuals with cerebral palsy.

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Section: Introductionmentioning

confidence: 99%

Altered spontaneous cortical activity predicts pain perception in individuals with cerebral palsy

Trevarrow

Reelfs

Ott

et al. 2022

Brain Communications

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“…Independent component analysis indicated reduced connectivity in the cerebellum network, sensorimotor network, and left lateral fronto‐parietal network in CP 41 . Also, reduced connectivity was observed in some areas between the visual network and sensorimotor and auditory regions, 42 while differences in connectivity within the visuomotor network were not significant in another study 29 . Using EEG, both increases and decreases in inter‐ and intrahemispheric connectivity in CP were reported 43 .…”

Section: Resultsmentioning

confidence: 91%

Brain structural and functional connectivity and network organization in cerebral palsy: A scoping review

Jacobs

Pouwels

Krogt

et al. 2023

Develop Med Child Neuro

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To explore altered structural and functional connectivity and network organization in cerebral palsy (CP), by clinical CP subtype (unilateral spastic, bilateral spastic, dyskinetic, and ataxic CP). Method: PubMed and Embase databases were systematically searched. Extracted data included clinical characteristics, analyses, outcome measures, and results. Results: Sixty-five studies were included, of which 50 investigated structural connectivity, and 20 investigated functional connectivity using functional magnetic resonance imaging (14 studies) or electroencephalography (six studies). Five of the 50 studies of structural connectivity and one of 14 of functional connectivity investigated whole-brain network organization. Most studies included patients with unilateral spastic CP; none included ataxic CP. Interpretation: Differences in structural and functional connectivity were observed between investigated clinical CP subtypes and typically developing individuals on a wide variety of measures, including efferent, afferent, interhemispheric, and intrahemispheric connections. Directions for future research include extending knowledge in underrepresented CP subtypes and methodologies, evaluating the prognostic potential of specific connectivity and network measures in neonates, and understanding therapeutic effects on brain connectivity.

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“…Other studies have found that youth with CP have increased FC in sensorimotor regions, and decreased FC between sensorimotor cortices and the cerebellum, visual and parietal cortices ( 15 , 17–19 ). A recent fMRI study from our laboratory has also reported an association between decreased FC in the occipital and sensorimotor cortices and the extent of alterations in the gait biomechanics of individuals with CP ( 20 ). This indicates that alterations in FC exist widely in youth with CP and that resting-state paradigms may have direct relevance to assessing the motor and cognitive dysfunction that is observed within this population.…”

Section: Introductionmentioning

confidence: 94%

Aberrant age-related alterations in spontaneous cortical activity in participants with cerebral palsy

et al. 2023

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IntroductionCerebral Palsy (CP) is the most common neurodevelopmental motor disability, resulting in life-long sensory, perception and motor impairments. Moreover, these impairments appear to drastically worsen as the population with CP transitions from adolescents to adulthood, although the underlying neurophysiological mechanisms remain poorly understood.MethodsWe began to address this knowledge gap by utilizing magnetoencephalographic (MEG) brain imaging to study how the amplitude of spontaneous cortical activity (i.e., resting state) is altered during this transition period in a cohort of 38 individuals with spastic diplegic CP (Age range = 9.80–47.50 years, 20 females) and 67 neurotypical controls (NT) (Age range = 9.08–49.40 years, Females = 27). MEG data from a five-minute eyes closed resting-state paradigm were source imaged, and the power within the delta (2–4 Hz), theta (5–7 Hz), alpha (8–12 Hz), beta (15–29 Hz), and gamma (30–59 Hz) frequency bands were computed.ResultsFor both groups, the delta and theta spontaneous power decreased in the bilateral temporoparietal and superior parietal regions with age, while alpha, beta, and gamma band spontaneous power increased in temporoparietal, frontoparietal and premotor regions with age. We also found a significant group x age interaction, such that participants with CP demonstrated significantly less age-related increases in the spontaneous beta activity in the bilateral sensorimotor cortices compared to NT controls.DiscussionOverall, these results demonstrate that the spontaneous neural activity in individuals with CP has an altered trajectory when transitioning from adolescents to adulthood. We suggest that these differences in spontaneous cortical activity may play a critical role in the aberrant motor actions seen in this patient group, and may provide a neurophysiological marker for assessing the effectiveness of current treatment strategies that are directed at improving the mobility and sensorimotor impairments seen in individuals with CP.

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Weaker Connectivity of the Cortical Networks Is Linked with the Uncharacteristic Gait in Youth with Cerebral Palsy

Cited by 9 publications

References 63 publications

Altered spontaneous cortical activity predicts pain perception in individuals with cerebral palsy

Altered spontaneous cortical activity predicts pain perception in individuals with cerebral palsy

Brain structural and functional connectivity and network organization in cerebral palsy: A scoping review

Aberrant age-related alterations in spontaneous cortical activity in participants with cerebral palsy

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