Wechselwirkungen zwischen Alkohol und Arzneimitteln

Soehring, K; Schüppel, R.

doi:10.1055/s-0028-1111611

Cited by 43 publications

(2 citation statements)

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“…Cross-tolerance to barbiturates has been demonstrated in alcohol-treated animals.v'-30 and alcoholic subjects have been shown to have increased resistance to several hypnotics and sedatives. 34 Pentobarbital tlh has been shown to be reduced in subjects treated with alcohol;" and there is evidence that pentobarbital hydroxylase activity is higher in liver biopsy samples of alcoholic patients.P Apparently, the amount of alcohol involvement in our poly-drug-abusing population was insufficient to lead to tolerance or increased elimination.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetic studies on tolerance to sedative‐hypnotics in a poly‐drug abuse population; I. Secobarbital

Faulkner

McGinity

Hayden

et al. 1978

Clin Pharma and Therapeutics

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Patients from a poly‐drug abuse treatment program with a history of sedative‐hypnotic abuse were titrated with secobarbital, their alleged drug of choice, to a minimal state of toxicity consisting of nystagmus, drowsiness, ataxia, and slurred speech. Volunteer control subjects underwent the same titration procedure. Blood level determinations were made, and several pharmacokinetic parameters were estimated in order to determine the nature and degree of tolerance in the patient population. The patients tolerated a titration dose which was slightly, but significantly. higher than that tolerated by the control group. Cellular tolerance could be demonstrated in terms of higher blood levels determined at 7.0 hr after the last dose but not at the onset of toxicity. A significantly greater β‐phase disposition constant and significantly smaller area under the curve per dose in the patient population suggested the contribution of drug disposition tolerance. Statistical comparisons of these parameters were made between several subgroups of the patient population. The patients indicating a higher frequency of sedative abuse did not differ from their patient counterparts. Those patients presenting with positive screens for barbiturates on admission provided similar results except for an apparently higher volume of distribution. Patients indicating concurrent alcohol use did not differ from the overall patient population; those also using amphetamines showed no sign of tolerance or increased elimination and were indistinguishable from control subjects.

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Section: Discussionmentioning

confidence: 99%

Pharmacokinetic studies on tolerance to sedative‐hypnotics in a poly‐drug abuse population; I. Secobarbital

Faulkner

McGinity

Hayden

et al. 1978

Clin Pharma and Therapeutics

View full text Add to dashboard Cite

show abstract

“…These components play a key role in the microsomal hydroxylation of various drugs and explain the welldocumented enhanced clearance of such drugs as meprobamate, pentobarbital and tolbutamide (Carulli and coworkers, 1971; Kater and coworkers, 1969b;Misra and coworkers, 1971; Vesell and coworkers, 1971). This metabolic adaptation evidently contributes to the tolerance of alcoholics for drugs, including sedatives (Soehring and Schuppel, 1966). Alcoholic liver injury may, however, interfere with drug elimination (Levi and coworkers, 1968).…”

Section: Interference Of Alcohol With Drug Metabolismmentioning

confidence: 99%