Weight gain in infancy and post‐bronchiolitis wheezing

Nuolivirta, Kirsi; Koponen, Petri; Helminen, Merja; Korppi, Matti

doi:10.1111/j.1651-2227.2011.02414.x

Cited by 10 publications

(6 citation statements)

References 24 publications

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“…We were not able to confirm the earlier observations that a rapid or excess weight gain in infancy increases the risk of later asthma . In this same cohort, the birth weight over 4,000 g and an excess weight gain in that subgroup before 6 months of age were associated with more post‐bronchiolitis wheezing until 1.5 years of age, but this was not anymore to be seen at the median age of 6.5 years. In a study of 197 American children at high risk for asthma, the early‐life weight gain pattern was not associated with daily asthma symptoms or lung function at 5‐ to 6‐years of age, but decelerated weight gain was associated with fewer emergency doctoral visits and less rescue treatments with corticosteroids .…”

Section: Discussioncontrasting

confidence: 99%

“…The cut‐off value of the z BMI for overweight was 1.16 for girls and 0.78 for boys (corresponding BMI of >25 kg/m 2 in young adults) and for obesity 2.11 for girls and 1.70 for boys (corresponding BMI of >30 kg/m 2 in young adults), respectively. Since national sex‐ and age‐specific height‐related BMI charts are available only from the age of 24 months onwards, overweight was defined as weight‐for‐length (WFL) >110% and obesity as WFL >120% at the 18‐month follow‐up visit, as published recently …”

Section: Methodsmentioning

confidence: 99%

“…However, a prospective intervention study in 197 children at risk for asthma from the US concluded that accelerated weight gain in infancy was not associated with asthma or reduced pulmonary function at pre‐school or early school age . The studies on the relationship between birth weight and asthma have reported varying results . Both low (<2.5 kg) and high (>4.5 kg) birth weight has been associated with later asthma .…”

Section: Introductionmentioning

confidence: 99%

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Excess weight in preschool children with a history of severe bronchiolitis is associated with asthma

Törmänen

Lauhkonen²,

Saari

et al. 2014

Pediatr Pulmonol.

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Section: Discussioncontrasting

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Excess weight in preschool children with a history of severe bronchiolitis is associated with asthma

Törmänen

Lauhkonen²,

Saari

et al. 2014

Pediatr Pulmonol.

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“…In this study, we found that higher birth weight was positively associated with respiratory infections in the first 2 years of life. While most studies have focused on low birth weight and respiratory morbidity in infancy, others have found the opposite, specifically that high birth weight was associated with post-bronchiolitis wheezing in infancy ( 61 ) and RSV LRTI ( 62 ). Although the mechanism remains to be elucidated, it has been suggested that macrosomia may be associated with an altered immunologic phenotype ( 63 ).…”

Section: Discussionmentioning

confidence: 99%

Food insecurity, vitamin D insufficiency and respiratory infections among Inuit children

Tse

Weiler

Kovesi

2016

International Journal of Circumpolar Health

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BackgroundFood insecurity, vitamin D deficiency and lower respiratory tract infections are highly prevalent conditions among Inuit children. However, the relationship between these conditions has not been examined in this population.ObjectiveThe objective of this study was to examine the relationship between food insecurity and severe respiratory infections before age 2 years and health centre visits for a respiratory problem in the past year. We also explored the relationship between serum vitamin D status and respiratory outcomes in this population.DesignWe included children aged 3–5 years who participated in a cross-sectional survey of the health of preschool Inuit children in Nunavut, Canada, from 2007 to 2008 (n=388). Parental reports of severe respiratory infections in the first 2 years of life and health care visits in the past 12 months were assessed through a questionnaire. Child and adult food security were assessed separately and serum 25-hydroxyvitamin D3 levels were measured in a subgroup of participants (n=279). Multivariate logistic regression was performed to assess the association between food security, vitamin D and each of the 2 respiratory outcomes.ResultsChild and adult food insecurity measures were not significantly associated with adverse respiratory outcomes. Household crowding [odds ratio (OR)=1.51, 95% confidence interval (CI) 1.09–2.09, p=0.01 for the child food security model] and higher birth weight (OR=1.21, 95% CI: 1.02–1.43, p=0.03) were associated with reported severe chest infections before age 2 years while increasing age was associated with decreased odds of reported health care visits for a respiratory problem (OR=0.66, 95% CI: 0.48–0.91, p=0.02). Neither vitamin D insufficiency nor deficiency was associated with these respiratory outcomes.ConclusionsUsing a large cross-sectional survey of Inuit children, we found that household crowding, but not food security or vitamin D levels, was associated with adverse respiratory outcomes. Further studies are warranted to examine the impact of decreasing household crowding on the respiratory health of these children.

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“…12 Similarly, being overweight (weight-for-length >110%) at 1.5 years of age was associated with recurrent post-bronchiolitis wheezing. 18 In contrast, being overweight or obese according to weight-for-length z-scores, was not significantly associated with clinical characteristics of viral acute bronchiolitis. 13 These results may differ because of the varying parameters used to define obesity in young children under 2 years of age.…”

Section: Discussionmentioning

confidence: 82%

Rapid weight gain in early life is associated with severity of respiratory syncytial virus (RSV) bronchiolitis in children

Kim

Cho

Lee

et al. 2021

aei

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Objectives: This study aimed to investigate whether rapid weight gain in early life was associated with the severity of respiratory syncytial virus (RSV) bronchiolitis in children.Methods: We retrospectively reviewed 190 patients (1–24 months) hospitalized for RSV bronchiolitis. Parameters of bronchiolitis severity were compared between rapid (change in weight z-score from birth >0.67, n = 65) and normal weight gain groups (n = 125). We assessed for correlations between bronchiolitis severity and weight gain. Linear regression was performed to predict for bronchiolitis severity based on weight gain, controlling for covariates. SPSS was used for statistical analyses.Results: The rapid weight gain group had longer mean durations of tachypnea (2.3±2.0 vs. 1.7±1.8 days, P = 0.027), wheezing (3.2±2.5 vs. 1.6±1.8 days, P < 0.001), and chest retractions (1.5±2.2 vs. 0.6±1.3 days, P = 0.007). Correlations of weight gain with tachypnea (r = 0.146), wheezing (r = 0.279), and chest retractions (r = 0.179) were statistically significant. Weight gain predicted for tachypnea (B = 0.485, P = 0.013) and wheezing (B = 0.846, P = 0.001) durations after adjusting for covariates of severity (age, sex, current weight, RSV type, coin-fection, recurrent bronchiolitis, hospital stay, fever, oxygen supplementation, maximal respi-ratory and heart rates, and laboratory indices).Conclusions: Our findings suggest an association between weight gain and severity of RSV bronchiolitis in young children. Weight gain was significantly associated with the durations of tachypnea and wheezing. The trajectory of weight gain in early life may play a significant role in the clinical course of RSV bronchiolitis.

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Weight gain in infancy and post‐bronchiolitis wheezing

Abstract: High birth weight and the development of overweight may be associated with post-bronchiolitis wheezing in infancy.

Cited by 10 publications

References 24 publications

Excess weight in preschool children with a history of severe bronchiolitis is associated with asthma

Excess weight in preschool children with a history of severe bronchiolitis is associated with asthma

Food insecurity, vitamin D insufficiency and respiratory infections among Inuit children

Rapid weight gain in early life is associated with severity of respiratory syncytial virus (RSV) bronchiolitis in children

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