What do we (need to) know about the kinetic properties of nanoparticles in the body?

Hagens, Werner I.; Oomen, Agnes G.; Jong, Wim H. de; Cassee, Flemming R.; Sips, A. J. A. M.

doi:10.1016/j.yrtph.2007.07.006

Cited by 412 publications

(235 citation statements)

References 94 publications

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“…These studies show a general pattern of translocation and biodistribution of TNPs that is illustrated in Fig. 3 [33]. All of the different exposure routes lead to blood entrance and translocation into various organs.…”

Section: Biodistribution and Systemic Toxicitymentioning

confidence: 79%

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The potential health risk of titania nanoparticles

Zhang

Bai

Zhang

et al. 2012

Journal of Hazardous Materials

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Section: Biodistribution and Systemic Toxicitymentioning

confidence: 79%

“…Photo-irradiation increased the level of ROS and decreased cell viability [61]. ROS-mediated protein Reprinted with permission from [33]. tyrosine nitration was also observed in mouse skin homogenate, although the relation of this finding to chronic cutaneous diseases needs further study [62].…”

Section: Skinmentioning

confidence: 99%

The potential health risk of titania nanoparticles

Zhang

Bai

Zhang

et al. 2012

Journal of Hazardous Materials

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“…Because, for example, lectin is such an immunologic material for coating, it can be toxigenic and also cause inflammatory responses or digestive stimulation. 25,26 Nanotitania toxicity Donaldson et al have shown that very small metal particles cause more inflammation than larger inhaled particles. Although the role of nanoparticles in toxicity is obscure, experimental evidence has shown that very small particles inhibit phagocytosis function more than larger particles.…”

Section: Toxicity Of Nanoparticlesmentioning

confidence: 99%

Nanotoxicology and nanoparticle safety in biomedical designs

Biazar²,

Jafarpour³

et al. 2011

IJN

153

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Nanotechnology has wide applications in many fields, especially in the biological sciences and medicine. Nanomaterials are applied as coating materials or in treatment and diagnosis. Nanoparticles such as titania, zirconia, silver, diamonds, iron oxides, carbon nanotubes, and biodegradable polymers have been studied in diagnosis and treatment. Many of these nanoparticles may have toxic effects on cells. Many factors such as size, inherent properties, and surface chemistry may cause nanoparticle toxicity. There are methods for improving the performance and reducing toxicity of nanoparticles in medical design, such as biocompatible coating materials or biodegradable/biocompatible nanoparticles. Most metal oxide nanoparticles show toxic effects, but no toxic effects have been observed with biocompatible coatings. Biodegradable nanoparticles are also used in the efficient design of medical materials, which will be reviewed in this article.

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“…The subject nanotechnology deals with manufacturing, study and manipulation of matter at nano scale in the size range of 1-100 nm which may be called as nanoparticles (Rajan, 2004). Nanotechnology represents the design, production and application of materials at atomic, molecular and macromolecular scales in order to produce new nanosized materials (Hahens et al, 2007). Nantechnology is mainly concerned with synthesis of nanoparticles of variable sizes, shapes, chemical compositions and controlled dispersity with their potential use for human benifits (Elumalai et al, 2010).…”

Section: Introductionmentioning

confidence: 99%