What is the impact of aminoglycoside exposure on soil and plant root-associated microbiota? A systematic review protocol

Abstract

Background Aminoglycosides are potent bactericidal antibiotics naturally produced by soil microorganisms and are commonly used in agriculture. Exposure to these antibiotics has the potential to cause shifts in the microorganisms that impact plant health. The systematic review described in this protocol will compile and synthesize literature on soil and plant root-associated microbiota, with special attention to aminoglycoside exposure. The systematic review should provide insight into how the soil and plant microbiota are impacted by aminoglycoside exposure with specific attention to the changes in the overall species richness and diversity (microbial composition), changes of the resistome (i.e. the changes in the quantification of resistance genes), and maintenance of plant health through suppression of pathogenic bacteria. Moreover, the proposed contribution will provide comprehensive information about data available to guide future primary research studies. This systematic review protocol is based on the question, “What is the impact of aminoglycoside exposure on the soil and plant root-associated microbiota?”. Methods A boolean search of academic databases and specific websites will be used to identify research articles, conference presentations and grey literature meeting the search criteria. All search results will be compiled and duplicates removed before title and abstract screening. Two reviewers will screen all the included titles and abstracts using a set of predefined inclusion criteria. Full-texts of all titles and abstracts meeting the eligibility criteria will be screened independently by two reviewers. Inclusion criteria will describe the eligible soil and plant root-associated microbiome populations of interest and eligible aminoglycosides constituting our exposure. Study validity will be evaluated using the CEE Critical Appraisal Tool Version 0.2 (Prototype) to evaluate the risk of bias in publications. Data from studies with a low risk of bias will be extracted and compiled into a narrative synthesis and summarized into tables and figures. If sufficient evidence is available, findings will be used to perform a meta-analysis.

Anthropocentric perspective on climate variability: the destination of antibiotics in the Tigris river is not restricted

“…Gentamycin, another selected antibiotic, belongs to the aminoglycoside group and is used increasingly in livestock and meat production (Economou & Gousia 2015). Gentamycin is indirectly delivered to the water surface from human wastewater, sewage sludge, and biosolids (Coates et al 2022). Although gentamycin is used for human treatment, a low concentration of gentamycin was detected in water, and the maximum concentration was at site 3 during the dry and wet seasons.…”

Ensuring food safety in use antimicrobial veterinary drugs in agriculture

“…Так, применяемые в ветеринарии некоторые антимикробные препараты, в неизмененном остаточном виде обнаруживаются в продуктах животноводства: мясе, молоке, яйце [12][13][14]. Часть из них выделяется животными во внешнюю среду с мочой и фекалиями, проникает в почву, грунтовые воды, растительность, в том числе продукты питания и корма для животных, а также губительно действует на естественную микрофлору почвы, изменяя ее свойства [15][16][17].…”