What is the Role of Laminin Receptor 1 in Human Reproduction?

Kurdoğlu, Mertihan; Kurdoğlu, Zehra

doi:10.15296/ijwhr.2015.24

Cited by 6 publications

(2 citation statements)

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“…This novel replication profiles of Brucella in human trophoblasts give insights into the pathogenesis of infectious abortion (58). It has also been hypothesised that laminin receptor 1 (LR1) which acts as a cell-surface receptor of laminin (a family of well-described extracellular matrix glycoproteins having many effects on cell adhesion, differentiation, migration, signalling and invasion) may also have a role in diminished invasive capacity of extravillous trophoblast-like cells in both animal and human abortions related to Brucella infections (59,60).…”

Section: Abortionsmentioning

confidence: 99%

The Effect of Brucellosis on Women’s Health and Reproduction

Kurdoğlu¹,

Cetin²,

Kurdoğlu³

et al. 2015

IJWHR

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IntroductionBrucellosis is a zoonotic disease of worldwide distribution which still remains endemic in some developing countries, causing devastating economic losses. Since it is transmissible to humans through direct contact with infected animals, consumption of their milk and dairy products, or inhalation of contaminated aerosols, it is considered a big threat for public health. At this point, the effect of Brucella infection on women's health and reproduction gains an extraordinary importance due to its potential harmful effects on female reproductive system and pregnancy. Therefore, in this report we aimed to review the available literature related to human brucellosis in order to characterize the basic microbiological features as well as the risk factors and clinical presentations of the disease and its complications related to various aspects of reproductive health. Materials and MethodsIn order to look for original articles, review articles, case series, case reports and editorials related to the effects of brucellosis on women's health and reproduction, various internet engines including PubMed, Up To Date, Google, Google Scholar and Cochrane Library were searched between February 2015 and June 2015. Directly or indirectly related information from 75 reports, the earliest reported in 1917 and the latest in 2015 were identified. The words used during the search process were "Brucella," "brucellosis, " "women's health, " "human pregnancy, " "human reproduction, " "abortion, " "preterm birth, " "intrauterine fetal demise, " and "intrauterine fetal death". Results General Features of Brucella Species and InfectionThe main pathogenic species worldwide are Brucella abortus (B. abortus), responsible for bovine brucellosis, Brucella melitensis (B. melitensis), the main etiologic agent of ovine and caprine brucellosis, and Brucella suis (B. suis), which has a wide host range, not being confined to swine (1). B. melitensis is responsible for the majority of human infections and is primarily food-borne. B. abortus and B. suis infections are generally sporadic and Brucella canis infections are the least common in humans and are generally laboratory-acquired (2,3). AbstractDue to its potential harmful effects on the general health and reproductive life of the women, in the light of available literature, it was aimed to review the effect of human brucellosis on women's health and reproduction. Data from 75 reports belonging to the years 1917 through 2015, obtained via a search on various internet sources by the words "Brucella", "brucellosis, " "women's health, " "human pregnancy, " "human reproduction, " "abortion, " "preterm birth, " "intrauterine fetal demise, " and "intrauterine fetal death" were used to characterize basic microbiological features together with the risk factors, clinical presentations and complications of the human brucellosis related to various aspects of reproductive well-being. A high rate of spontaneous abortion was a more consistent finding rather than high rates of preterm delivery and intra...

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Section: Abortionsmentioning

confidence: 99%

The Effect of Brucellosis on Women’s Health and Reproduction

Kurdoğlu¹,

Cetin²,

Kurdoğlu³

et al. 2015

IJWHR

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“…"Laminin receptor 1" may also have an important role in human reproduction. Its decreased expression has also been linked to shallow trophoblastic invasion which may lead to pre-eclampsia (54,57,58). Of course such molecules have variety of kinds and the mentioned references (53,55,56) are not merely related to endometrium and it's upon us to study further.…”

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confidence: 99%

A Review on Controversies about the Role of Immune and Inflammatory Systems in Implantation Process and Durability of Pregnancy

Ahmadi¹,

Shahsavar²,

Akbari³

2016

IJWHR

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IntroductionAmong the controversies in reproduction science, role of immune and inflammatory systems in implantation process and durability of pregnancy is a hot topic nowadays. Some researchers and practitioners believe that administration of drugs such as prednisolone, aspirin or heparin can improve success rate of implantation and pregnancy through inhibiting coagulation, inflammatory and immune systems; while others believe that such systems not only do not have negative effect on rejecting blastocyst and embryo by itself but also are necessary for implantation and remodeling of uterine spiral arteries through secreting adhesive and angiogenic factors. Such controversies are proposed both in natural pregnancies resulting in spontaneous abortion as well as in successful and/or unsuccessful assisted reproductive technologies (ARTs). Recurrent spontaneous abortion (RSA) is defined as having 3 or more history of abortion (1). About the other issue, some researchers and practitioners are grumbling of low success rate of ARTs like in vitro fertilization (IVF). Infertility is a problem for 10%-15% of couples; most of which -but not all -require ART (2). The average fertilization rate of ART in previous researches has been reported about 30% (3) and this report is for 1998. It has been claimed in an article published in 2015 that this rate has improved in the recent decade (4). Even though at the first glance this rate seems low, but the interesting point is that in the claim of a valid reference (5) the chance of natural pregnancy for each intercourse per month does not go up more than 33%. Also this number has been reported in some studies up to 40% (6). Thus, we should not be grumbling of the low fertilization rate of ARTs. Finally we intend to represent and report our insights, reasoning and suggestions in the present review. MethodsThis systematic and critical review includes investigation of scientific data bases and tracing the citations and the references of the articles in order to find the root of the truth. Through this wisdom, we showed the mere that a content proposed in an indexed article is not a reason that this content is valid and able to be cited. Indeed, the researcher should regard and notice the reasoning, citations and protocol of his/her references during the literature review. This is the benefit point of systematic review rather than holistic and narrative reviews. Since some data were few, the time period of publications was not important to us. As the searching strategy, we used the Web of Science Core Collection and Google Scholar for finding articles other than ISI-WOS and the tracing mentioned in the above paragraph. Results and DiscussionRole of Immune System and Leukocytes In 2015, Ghafourian et al (1) by measuring the level of natural killer-cells (NKs) in blood of the RSA and the control group concluded that RSA patients in normal (non-preg- AbstractAmong the controversies about reproduction sciences, role of immune and inflammatory systems in implantation process and durability of...

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