Metribuzin will control many problematic weed species in winter wheat in the mid-Atlantic states, including herbicide-resistant biotypes, but it has not been recommended due to crop safety concerns. In a three-year trial, metribuzin was applied at 105 or 210 g ai ha −1 to wheat at the PRE, 2-leaf (Feekes stage 1 to 2), early spring (Feekes stage 3 to 4), and late spring (Feekes stage 4 to 6) growth stages using wheat cultivars sensitive to metribuzin. Early spring applications had the least amount of injury, and injury at this timing was transient and yield was not reduced. Yield loss was observed with the other application timings in at least one out of three years. Rainfall shortly after application appears to increase the risk of wheat injury. Nomenclature: metribuzin, wheat, Triticum aestivum L. Key words: Crop safety, herbicide injury.Metribuzin controlará muchas especies de malezas problemáticas en trigo de invierno en los estados del Atlántico medio, incluyendo biotipos resistentes a herbicidas, pero no ha sido recomendado debido a preocupación sobre su seguridad en el cultivo. En un ensayo durante tres años, se aplicó metribuzin a 105 ó 210 g ai ha −1 al trigo en los estadios de crecimiento PRE, 2-hojas (estadios Feekes 1 a 2), temprano en la primavera (estadios Feekes 3 a 4), y tarde en la primavera (estadios Feekes 4 a 6) usando cultivares de trigo sensibles a metribuzin. Las aplicaciones temprano en la primavera tuvieron la menor magnitud de daño, y el daño en este momento de aplicación fue temporal y el rendimiento no se redujo. Se observó pérdida en el rendimiento con otros momentos de aplicación en uno de los tres años. Eventos de lluvia poco después de las aplicaciones parecen aumentar el riesgo de daño en el trigo.Soft red winter wheat is grown on over 300,000 ha in the Mid-Atlantic region of the United States (USDA 2015). Winter wheat in this region provides a fall-planted crop that increases the diversity of farmers' rotations. Also, the ability to plant soybean [Glycine max (L.) Merr.] immediately after wheat harvest in this region allows for an additional grain marketing opportunity.Winter annual weeds, both broadleaf and grass species, are problematic for small grains. Farmers in the mid-Atlantic region have successfully used acetolactate synthase (ALS)-inhibiting herbicides since early 1990s as their mainstay for weed control. As a result, there has been a shift towards species that are not effectively controlled with this herbicide family, such as henbit (Lamium amplexicaule L.), ivyleaf speedwell (Veronica hederifolia L.), and annual bluegrass (Poa annua L.) (BA Scott, personal observation). In addition, there are confirmed ALS-resistant biotypes of common chickweed [Stellaria media (L.)Vill.], Italian ryegrass (Lolium perenne L. ssp. multiflorum (Lam.) Husnot), and horseweed [Conyza canadensis (L.) Cronq.]. The prevalence of these species has forced farmers to seek alternative herbicides for small grain production.Metribuzin is an herbicide that may improve small grain weed control for g...