Which Endometrial Pathologies Need Intraoperative Frozen Sections?

Balık, Gülşah; Kağıtçı, Mehmet; Üstüner, İşık; Akpınar, Funda; Güven, Emine Seda Güvendağ

doi:10.7314/apjcp.2013.14.10.6121

Cited by 14 publications

(12 citation statements)

References 26 publications

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“…It is fourth common cancer after breast, lung and colon cancers in women. Most malignancy cases are found in women aged 50 and over, with more than half of all endometrial cancer cases diagnosed in the 50-69 age group (Balik et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

The Polymorphism of Hypoxia-inducible Factor-1a Gene in Endometrial Cancer

Kafshdooz¹,

Tabrizi²,

Mohaddes³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Endometral carcinoma is the most common malignant tumor of the female genital tract and the fourth most common cancer in women after breast, colorectal and lung cancers Hypoxia-inducible factor -1 (HIF-1) is a key transcription factor that regulates cellular response to hypoxia HIF-1 plays important roles in the development and progression of cancer through activation of various genes that are involved in crucial aspects of cancer biology, including angiogenesis, energy metabolism, vasomotor function, erythropoiesis, and cell survival. In this study, we aimed to investigate the association between HIF-1 1772 C/T polymorphisms and endometrial cancer. Materials and Methods: 75 patients with endometrial carcinoma and 75 patients whose underwent hysterectomy for non tumoral indication selected for evaluation of HIF-1 1772 C/T polymorphisms by PCR-RFLP and sequencing. Results: For the 1772 C/T polymorphism, the analysis showed that the T allele and genotype TT were significantly associated with endometrial cancer risk. Conclusions: Our results suggest that the C1772T polymorphism of the HIF-1a may be associated with endometrial cancers.

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Section: Discussionmentioning

confidence: 99%

The Polymorphism of Hypoxia-inducible Factor-1a Gene in Endometrial Cancer

Kafshdooz¹,

Tabrizi²,

Mohaddes³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…In ultrasound examination, they may be mimic as increased endometrial thickness and especially in postmenopausal women may be misdiagnosed as endometrial cancer (Balik et al, 2013). EH is a clinically important because it may result abnormal uterine bleeding, and can precede, or occur concurrently, with endometrial carcinoma (Kim et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Endometrial hyperplasia (EH) is the abnormal proliferation of the endometrial glands and stroma and related with risk of increased endometrial carcinoma (Li et al, 2013). Both EP and EH are related with endometrial cancer especially in post-menopausal women (Balik et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Risk Factors for Endometrial Hyperplasia Concomitant Endometrial Polyps in Pre- and Post-menopausal Women

Topçu¹,

Erkaya²,

Güzel³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Purpose: To evaluate the risk factors for endometrial hyperplasia concomitant endometrial polyps in preand post-menopausal women. Materials and Methods: A total of 203 patients undergoing endometrial sampling before hysterectomy were evaluated in this retrospective study. Data recorded were age, gravidity, parity, body mass index (BMI: weight(kg)/height(m) 2 ), endometrial thickness (ET), menopausal status, presence of adenomyosis and diabetes mellitus. Results: Endometrial hyperplasia and polyps were detected in 13 patients. There were statistically significant differences in terms of age, menopausal status, morbid obesity and diabetes mellitus (p<0.005). Logistic regression demonstrated that menopausal status and presence of diabetes mellitus were independent risk factors. Conclusions: According to the current study; menopause and diabetes mellitus are strong risk factors for the presence of concomitant endometrial polyps and endometrial hyperplasia.

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“…Their reported accuracy is 65%. Balik et al report FS detects only 10 patients out of 17 EC with a sensitivity and specificity rate of 58.8% and 100%, respectively (Balik et al, 2013 Montalto et al, 2008).…”

Section: Discussionmentioning

confidence: 99%