Which is more important for cardiometabolic health: sedentary time, higher intensity physical activity or cardiorespiratory fitness? The Maastricht Study

Velde, Jeroen H. P. M. van der; Schaper, Nicolaas C.; Stehouwer, Coen D. A.; Kallen, Carla; Sep, Simone J. S.; Schram, Miranda T.; Henry, Ronald M.A.; Dagnelie, Pieter C.; Eussen, Simone J. P. M.; Dongen, M.C.J.M. van; Savelberg, Hans; Koster, Annemarie

doi:10.1007/s00125-018-4719-7

Cited by 46 publications

(51 citation statements)

References 39 publications

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“…Each of higher levels of total PA, greater lean mass, and higher vitamin D status were associated with lower risk of MetS in men and women. These results are consistent with other studies that have examined separately PA, lean mass and vitamin D as risk predictors for MetS or diabetes. By examining all these factors within a single study, we are able to compare the magnitude of associations between PA, lean mass and vitamin D with this outcome.…”

Section: Discussionsupporting

confidence: 92%

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U‐shaped association of vigorous physical activity with risk of metabolic syndrome in men with low lean mass, and no interaction of physical activity and serum 25‐hydroxyvitamin D with metabolic syndrome risk

Yeap

Dedic

Budgeon

et al. 2020

Internal Medicine Journal

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Background: There is uncertainty over how lean mass, physical activity (PA) and 25-hydroxyvitamin D (25-OH-D) status interact on metabolic syndrome (MetS) risk in adults. Aims:To test the hypothesis that these factors additively influence MetS risk. Methods: Four thousand eight hundred and fifty-eight adults (54.6% female) mean AE SD age 58.0 AE 5.8 years, body mass index 28.1 AE 4.8 kg/m 2 , resident in Busselton, Western Australia. PA assessed by questionnaire (all/total and vigorous), lean mass using dual energy X-ray absorptiometry (% total body mass), serum 25-OH-D via immunoassay, analysed using multivariable logistic regression.Results: In men, lower total PA was associated with MetS (no vs >24 h/week odds ratio (OR) = 3.1; ≤8 vs >24 h/week OR = 1.8, both P < 0.001), as was lower lean mass (low vs high OR = 20.4; medium vs high OR = 7.4, both P < 0.001). Men with low lean mass exhibited a U-shaped relationship of vigorous PA with MetS risk (covariateadjusted: 0 vs 4-8 h/week OR = 2.1, P = 0.037; >12 vs 4-8 h/week OR = 4.3, P = 0.002; interaction P = 0.039). In women, low PA (0 vs >24 h/week OR = 2.1, P = 0.003) and lean mass (low vs high OR = 13.1; medium vs high OR = 7.2, both P < 0.001) were associated with MetS risk. Low 25-OH-D status was associated with MetS in men (low vs high OR = 4.1; medium vs high OR = 2.3, both P < 0.001) and women (OR = 3.5 and 2.1 respectively, both P < 0.001) with no PA interaction.Conclusions: Men and women with high lean mass have low risk of MetS regardless of PA. Low lean mass identifies men who may benefit most from increasing PA, with an optimal level associated with lowest risk. 25-OH-D and PA do not interact on MetS risk.

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Section: Discussionsupporting

confidence: 92%

“…Both increased availability of energy‐dense foods and increasingly sedentary lifestyles are implicated in MetS development . Conversely, higher levels of physical activity (PA) across a range of intensities are associated with reduced risk of MetS …”

Section: Introductionmentioning

confidence: 99%

U‐shaped association of vigorous physical activity with risk of metabolic syndrome in men with low lean mass, and no interaction of physical activity and serum 25‐hydroxyvitamin D with metabolic syndrome risk

Yeap

Dedic

Budgeon

et al. 2020

Internal Medicine Journal

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“…In contrast, a previous study demonstrated that poor mobility with a high fall risk is linked to hyperglycemic status even in younger patients with a short duration of T2D [19]. Also, low cardiorespiratory fitness is associated with an increase in the risk of having metabolic syndrome and T2D, independent of physical activity and sedentary time [20]. Therefore, impaired physical ability in addition to physical inactivity and a sedentary lifestyle may warrant more attention from healthcare providers in terms of glycemic management individualized for each patient with T2D.…”

Section: Discussionmentioning

confidence: 74%

Association of One-Leg Standing Time with Discontinuation of Injectable Medications During Hospitalization Among Patients with Type 2 Diabetes

et al. 2020

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Introduction: Persons with type 2 diabetes (T2D) are known to experience impaired physical ability even at the early stages of the disease. However, less attention has been paid to increasing physical ability than to increasing physical activity in the treatment of T2D. The aim of this study was to assess whether Digital features To view digital features for this article go to https://doi.org/10.6084/m9.figshare.12040566.

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“…The first-day of data were excluded, and subsequent days were defined as the 24 hours between consecutive midnights. Only participants providing at least one valid day, defined as waking wear time more than 10 hours per day, were included for further analysis (13).…”

Section: Sedentary Behavior and Other Physical Activity Variablesmentioning

confidence: 99%

“…Thigh-worn accelerometry has better-established validity and reliability for measuring posture, activity intensity, and ambulatory movement in free-living conditions in adults (10)(11)(12). To date, the most extensive cross-sectional study using thigh-worn accelerometers (13) suggested that the odds ratios of metabolic syndrome and type 2 diabetes were higher in individuals with higher sedentary time or lower moderate-to-vigorous physical activity. Another relatively small-scale cross-sectional study (14) found that the number of breaks in sedentary time was beneficially associated with cardiometabolic health markers, e.g., body mass index, waist circumference, high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG).…”

Section: Introductionmentioning

confidence: 99%

Independent and Joint Associations of Sedentary Behavior and Physical Activity with Cardiometabolic Health Markers in the 1970 British Birth Cohort

Huang

Hamer

Chastin

et al. 2019

Preprint

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Objective To examine the independent and joint associations thigh-worn accelerometry assessed sedentary time and moderate to vigorous physical activity with cardiometabolic health markers. Design Cross-sectional study embedded in the age-46 wave an established birth cohort, the 1970 British Birth Cohort. Setting Population-based sample from Great Britain (England, Scotland, and Wales). Methods Outcome measures included: body mass index, waist-to-hip ratio, blood pressure, glycated hemoglobin, high-density lipoprotein cholesterol, total cholesterol, triglycerides, and c-reactive protein. Sedentary behavior and other physical activity exposures, recorded by a thigh-worn activPAL3 accelerometry, included: daily sedentary time, breaks in sedentary time, daily time spent in moderate-to-vigorous physical activity. Multiple linear regression analyses, multiple logistic regression analyses, and general linear models were conducted as applicable. Results 4,634 participants were available for the final analysis. After adjusting for potential confounders and moderate-to-vigorous physical activity, daily sedentary time was positively associated with triglycerides (β=0.052 [0.015, 0.089]) and inversely associated with high-density lipoprotein cholesterol (β=-0.015 [-0.022, -0.010]). Daily prolonged sedentary time (≥ 60 minutes) was positively associated with both glycated hemoglobin and log-transformed c-reactive protein (β=0.240 [0.030, 0.440] and 0.026 [0.007, 0.045], respectively) and inversely associated with systolic blood pressure and high-density lipoprotein cholesterol (β=-0.450 [-0.760, -0.150] and -0.013 [-0.022, -0.003], respectively). After adjusting for potential confounders and daily sedentary time, daily breaks in sedentary time were inversely associated with glycated hemoglobin (β=-0.020 [-0.037, -0.003]), and positively associated with both triglycerides and systolic blood pressure (β=0.006 [0.002, 0.010] and 0.030 [0.002, 0.050], respectively). The joint associations of prolonged sedentary time and moderate-to-vigorous physical activity with the prevalence of diabetes were not statistically significant. Conclusion Prolonged sedentary time (≥ 60 minutes) and daily breaks in sedentary time were deleteriously associated with glycated hemoglobin, although we found no evidence that there were joint moderate-to-vigorous physical activity and sitting associations.

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Which is more important for cardiometabolic health: sedentary time, higher intensity physical activity or cardiorespiratory fitness? The Maastricht Study

Cited by 46 publications

References 39 publications

U‐shaped association of vigorous physical activity with risk of metabolic syndrome in men with low lean mass, and no interaction of physical activity and serum 25‐hydroxyvitamin D with metabolic syndrome risk

U‐shaped association of vigorous physical activity with risk of metabolic syndrome in men with low lean mass, and no interaction of physical activity and serum 25‐hydroxyvitamin D with metabolic syndrome risk

Association of One-Leg Standing Time with Discontinuation of Injectable Medications During Hospitalization Among Patients with Type 2 Diabetes

Independent and Joint Associations of Sedentary Behavior and Physical Activity with Cardiometabolic Health Markers in the 1970 British Birth Cohort

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