Background-Quantification of the mitral valve area (MVA) is important to guide percutaneous mitral valve repair using the MitraClip system. However, little is known about how to best assess MVA in this specific situation. Methods and Results-Immediately before and after MitraClip implantation, transesophageal echocardiography data were acquired for MVA assessment by the pressure half-time method and by two 3D quantification methods (mitral valve quantification software and 3D quantification software). In addition, transmitral gradients by continuous-wave Doppler (dPmean CW ) were measured to indirectly assess MVA. Data are given as median (interquartile range). Thirty-three patients (39% women) with a median age of 77.1 years (12.4 years) were studied. Before intervention, the median MVAs by the pressure half-time method, mitral valve quantification software, and 3D quantification software were 4.4 cm 2 (2.0 cm 2 ), 4.7 cm 2 (2.4 cm 2 ), and 6.2 cm 2 (2.4 cm 2 ), respectively (P<0.001). After intervention, MVA was reduced to 1.9 cm 2 (0.7 cm 2 ), 2.1 cm 2 (1.1 cm 2 ), and 2.8 cm 2 (1.1 cm 2 ), respectively (P=0.001). The median values for dPmean CW before and after intervention were 1.0 mm Hg (1.0 mm Hg) and 3.0 mm Hg (3.0 mm Hg; P<0.001), respectively. At discharge, the median dPmean CW was 4.0 mm Hg (3.0 mm Hg). In multivariate regression analyses including body surface area, the 3 different MVA methods, and dPmean CW , a post-dPmean CW ≥5 mm Hg was the best independent predictor of an elevated transmitral gradient at discharge.
Methods
Patient PopulationWe included consecutive patients undergoing percutaneous MVR using the MitraClip system at the University Hospital Zurich, Zurich, Switzerland. Patients were selected for the procedure according to both the current guidelines on valvular heart disease and the previously published guidelines. 1,10,11 The clinical patient data were obtained by chart review. All patients gave written informed consent for inclusion in a prospective MitraClip registry (MitraSwiss registry). The protocol of the MitraSwiss registry was approved by the local institutional review board.
EchocardiographyTEE was performed using a Philips iE33 platform and an X7-2t real-time 3D TEE probe (Philips Medical Systems, Andover, MA). A 2D TTE was performed in all patients at the time of discharge. All measurements were performed according to the guidelines.12 MR was graded mild (1+), moderate (2+), moderate to severe (3+), and severe (4+).11 Mitral stenosis was defined by an MVA <2 cm 2 : mild, by 1.5 to 1.99 cm 2 ; moderate, by 1.0 to 1.49 cm 2 ; and severe, by <1 cm 2 . In addition, a mean transvalvular gradient ≥5 mm Hg was considered stenosed mitral valve. 4,13 Immediately before the start of the procedure and after the last clip was placed, continuous-wave (CW) Doppler of mitral valve inflow was used for the assessment of the mean gradient across the mitral valve (dPmean CW ) and of MVA by PHT (MVA PHT ). 9 The beam of the CW Doppler was located in the center of the largest orifice after ...