Whispering-gallery-mode resonance sensor for dielectric sensing of drug tablets

Neshat, Mohammad; Chen, Huanyu; Gigoyan, Suren; Saeedkia, Daryoosh; Safavi‐Naeini, Safieddin

doi:10.1088/0957-0233/21/1/015202

Cited by 18 publications

(10 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In [17] a waveguide transmission probe was clamped onto the ear of a live anesthetic rat in order to observe the EM properties continuously on VNA. The authors recorded a correlation between blood glucose concentrations and the absorption/reflection properties of the mm-wave transmitted in the Ka band (27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40) as demonstrated by the considerable changes in the absorption/reflection parameters during the 0.5 mL intraperitoneal (IP) injection of glucose and insulin into the rat under experiment. A recent study in [29] proposed a mm-wave sensing system that consists of a pair of 60 GHz microstrip patch antennas placed across the interrogated blood sample.…”

Section: Dielectric Properties Of Glucose-loaded Solutions At Mm-mentioning

confidence: 99%

WGM-Based Sensing of Characterized Glucose- Aqueous Solutions at mm-Waves

et al. 2020

Self Cite

View full text Add to dashboard Cite

A newly-developed commercial coaxial probe kit (DAK-TL) is used to characterize the electromagnetic properties of glucose-loaded samples prepared at a range of concentrations 0.7-1.2 mg/ml similar to Type-2 normal diabetics in a broad range of frequencies from 300 MHz to 67 GHz using two different 50 open-ended coaxial probes. The objective is to determine the spectrum portion of the most sensitivity to slight variations in glucose concentrations and to identify the amount of change in the dielectric permittivity and loss tangent due to different concentrations of interest. The millimeter-wave range 50-67 GHz has shown to be promising for acquiring both high sensitivity and sufficient penetration depth for the most interaction between the glucose molecules and electromagnetic waves. Subsequently, the relative permittivity of the glucose-water mimicking samples are modeled in this mm-wave band using a single-pole Debye model with independent coefficients. The fitted Debye model is used to design a simple low-cost highly-sensitive integrated mm-wave sensing structure that utilizes the travelling-wave Whispering Gallery Modes (WGMs) launched in a dielectric disc resonator (DDR) when coupled to a dielectric image waveguide (DIG). The proposed sensor is used for continuous monitoring of glucose levels in blood mimicking aquatic solutions by tracking the variations in the magnitude and phase of the WGM transmission resonances in the mm-wave spectrum. This happens in reaction to the strong interactions of the coupled WGM evanescent field with the glucose samples loaded on top of the DDR inside a container. The sensor exhibits a high sensitivity performance (2.5-7.7 dB/[mg/ml]) for the two proposed DIG layouts, straight and curved, at the lower-order modes WGH 600 and WGH 700 of its five pure WGH modes supported in the frequency range 50-70 GHz as demonstrated by numerical simulations in a 3D full-wave EM solver and validated through proof-of-concept measurements.INDEX TERMS Debye model, dielectric characterization, mm-wave sensing, non-invasive glucose detection, WGM resonator.ALA ELDIN OMER (Student Member, IEEE) received the primary and secondary education in Khartoum, Sudan. He was ranked as the third top student over whole Sudan ranking in the Sudanese High School Certificate (SHSC) with an average of (96.4%). He received the B.Sc. degree (magna cum laude) in electrical and electronics engineering with specialization in communication engineering from the University of Khartoum, Sudan, in 2013, the M.Sc. degree (summa cum laude) in electrical engineering from the American University of Sharjah (AUS), in 2016, where he was awarded a two-year Graduate Assistantship from the Department of Electrical Engineering. He is currently pursuing the Ph.D. degree with the Centre for Intelligent Antenna and Radio Systems (CIARS),

show abstract

Section: Dielectric Properties Of Glucose-loaded Solutions At Mm-mentioning

confidence: 99%

WGM-Based Sensing of Characterized Glucose- Aqueous Solutions at mm-Waves

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Our proposed circular SIW cavity sensor also achieved a largest frequency shift and highest sensitivity for ethanol chemical. Some highly appreciated works using GHz-THz frequency band, sensing biomaterials, petrol, propanol, and other aqueous solutions using both optical and RF sensing mechanism are mentioned here [ 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ].…”

Section: Experimental Demonstrationmentioning

confidence: 99%

Microfluidic High-Q Circular Substrate-Integrated Waveguide (SIW) Cavity for Radio Frequency (RF) Chemical Liquid Sensing

Memon

Lim

2018

Sensors

View full text Add to dashboard Cite

In this study, a high-Q circular substrate-integrated waveguide (SIW) cavity resonator is proposed as a non-contact and non-invasive radio frequency (RF) sensor for chemical sensing applications. The design of the structure utilizes SIW technology along with a circular shape to achieve a high unloaded Q factor, which is one of the important requirements for RF sensors. The resonant frequency of the proposed circular SIW cavity sensor changes when a liquid material or a chemical (microliters) is inserted in the sensitive area of the structure. The sensing of liquid materials with different permittivities is accomplished via the perturbation of the electric fields in the SIW configuration. When a microwell that is 4 mm in radius is installed vertically through the center of the bare circular SIW cavity, the operating frequency varies from 5.26 to 5.34 GHz. Similarly, when the microwell contains ethanol, the frequency shifts from 5.26 to 5.18 GHz, and the amplitude of reflection coefficient is shifted from −29 dB to −17 dB; when the microwell contains mixing deionized (DI)-water, the frequency moves from 5.26 to 4.98 GHz (which is also 0% Ethanol in our study), and the amplitude of reflection coefficient is shifted from −29 dB to −8 dB. A high unloaded Q factor is maintained throughout all experimental results. To demonstrate our idea, different concentrations of ethanol are tested and recorded. The experimental validation yields a close agreement between the simulations and the measurements.

show abstract

“…The works on plasmonic MMs [ 1 , 2 , 9 ] as well as on meta-surfaces [ 10 , 11 , 12 ], in particular, on those formed of DRs [ 13 ] have already proved new opportunities for sensing based on FRs in THz and optical range. Comparably high-Q values have been achieved only at resonances of Whispering Gallery Modes (WGM) [ 14 ] or in resonance cavities including built-in PhC defects of periodicity [ 15 ], however, excitation of these resonances demanded more complicated designs and fabrication techniques compared to metasurfaces. In addition, it is challenging in practice to vary Q-factors of these resonances, while Q-factor control is often required for matching the parameters of the resonance and the sensitivity of peak detectors used for resonance surveillance.…”

Section: Introductionmentioning

confidence: 99%

Sensing Based on Fano-Type Resonance Response of All-Dielectric Metamaterials

Semouchkina

Duan

Semouchkin

et al. 2015

Sensors

View full text Add to dashboard Cite

A new sensing approach utilizing Mie resonances in metamaterial arrays composed of dielectric resonators is proposed. These arrays were found to exhibit specific, extremely high-Q factor (up to 15,000) resonances at frequencies corresponding to the lower edge of the array second transmission band. The observed resonances possessed with features typical for Fano resonances (FRs), which were initially revealed in atomic processes and recently detected in macro-structures, where they resulted from interference between local resonances and a continuum of background waves. Our studies demonstrate that frequencies and strength of Fano-type resonances in all-dielectric arrays are defined by interaction between local Mie resonances and Fabry-Perot oscillations of Bloch eigenmodes that makes possible controlling the resonance responses by changing array arrangements. The opportunity for obtaining high-Q responses in compact arrays is investigated and promising designs for sensing the dielectric properties of analytes in the ambient are proposed.

show abstract

Whispering-gallery-mode resonance sensor for dielectric sensing of drug tablets

Cited by 18 publications

References 29 publications

WGM-Based Sensing of Characterized Glucose- Aqueous Solutions at mm-Waves

WGM-Based Sensing of Characterized Glucose- Aqueous Solutions at mm-Waves

Microfluidic High-Q Circular Substrate-Integrated Waveguide (SIW) Cavity for Radio Frequency (RF) Chemical Liquid Sensing

Sensing Based on Fano-Type Resonance Response of All-Dielectric Metamaterials

Contact Info

Product

Resources

About