White blood cell and platelet indices as prognostic markers in patients with invasive ductal breast carcinoma

Abstract

Abstract.A growing body of evidence suggests that oncogenesis is associated with systemic inflammation. The present study investigated white blood cell and platelet indices, whose values change during the inflammatory response, in women with invasive ductal breast carcinoma. Preoperatively obtained white blood cell and platelet counts from 53 patients with early breast cancer, who developed systemic metastases over a mean follow-up period of 65 months, were analyzed and compared with those of a matching control group formed of 37 patients with the same characteristics, who remained recurrence-free during the same time period. Patients who developed distant metastasis had a significantly higher mean platelet volume and lower neutrophil count than patients who did not present with distant metastasis. Furthermore, time to distant metastasis development was longer in patients with a lower mean platelet volume, whilst patients with a lower neutrophil count had a shorter systemic disease-free time interval. However, receiver operating characteristic curve analysis demonstrated that these parameters provided moderate accuracy in predicting which patients may develop distant metastasis. No differences were detected between patient groups regarding additional parameters. Patients who developed systemic disease during a mean follow-up period of 65 months were observed to have an increased mean platelet volume and decreased neutrophil count preoperatively. These results indicate that such parameters may be of prognostic value in patients with breast cancer. Studies with a larger number of patients are required to further investigate this hypothesis.

Association of Platelet Count and Platelet Indices with Stages of Women Breast Cancer in Yola, Nigeria

“…MPV was observed to increases with increase in cancer stage in this present study it is believed that, platelet size as reflected by MPV do increases in direct proportion to breast cancer progression. MPV value can also reflect the level of invasiveness of cancer cell [21] and high MPV is an indices of inflammation [17,23] it therefore goes to show that higher MPV value (than that of control observed in this study) may indicates high level of invasiveness and inflammatory processes in women with breast cancer and this inflammatory processes tends to increase as the stages of breast cancer increases. In addition, MPV value is a pointer to level of platelet function and activation [16] hence, increase in MPV implies increase platelet activation in this group of patients.…”

“…MPV is a test parameter that may be useful in identifying patients with newly diagnosed invasive ductal breast carcinoma [21] and elevated MPV value is associated with other markers of platelet activity including: platelet aggregation, increased thromboxane synthesis and β-thromboglobulin release [22].…”

“…Breast cancer is often divided into stages usually expressed as a number on a scale of 0 through IV with stage 0 describing non-invasive cancers that remain within their original location and stage IV describing invasive cancers that have spread outside the breast to other parts of the body. Despite multi-approaches in therapeutic management of breast cancer, including surgical, chemotherapy and radiation therapy, breast carcinoma remains a big clinical challenge and platelet indices may be useful in managing patients with breast cancer [21]. In Yola like most part of Nigeria however, information regarding platelet and platelet indices at various stages of breast cancer is not yet fully studied and documented, this study therefore aims to evaluate platelet count and platelet indices in women at various stages of breast cancer in Yola Nigeria in other highlights the usefulness of platelet count and platelet indices in the clinical management of women with breast cancer in this locality.…”

Assessment of platelet reactivity after the anthracyclinebased chemotherapy via mean platelet volume: Does it act on anthracycline-induced cardiotoxicity?

“…In malignant tumors, platelets can lead to tumor progression and angiogenesis. High MPV is associated with uncontrolled and metastatic disease [24][25][26][27][28][29]. Therefore, in this study, we excluded the un-operated and metastatic patients due to a probable rise in MPV value.…”

Effect of selected plants on Haematological parameters of DMBA-induced breast cancer of albino rats

“…There are several diverse types of breast malignancy, with different stages (spread), aggressiveness, and genetic makeup [9]. Regardless of the numerous approaches in the treatment of breast cancer such as surgery, chemotherapy and radiation, metastatic disease still remains a great clinical challenge [10].…”