White Blood Cell Count and Risk of All-Cause and Cardiovascular Mortality in Nationwide Sample of Japanese

Koji, Takehiko; Toyoshima, Hideaki; Yatsuya, Hiroshi; Matsushita, Kunihiro; Okamura, Tomonori; Hayakawa, Takehito; Okayama, Akira; Ueshima, Hirotsugu

doi:10.1253/circj.71.479

Cited by 61 publications

(43 citation statements)

References 24 publications

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“…45 (21) in Japanese men, not in women (39). Tamakoshi et al reported that elevated WBC was nearly significantly associated with a high risk of cardiovascular disease mortality in Japanese (19).…”

Section: Drome) (21) Is That It Regards Subcutaneous Adipose Tissue Amentioning

confidence: 99%

Comparison between High-Sensitivity C-Reactive Protein (hs-CRP) and White Blood Cell Count (WBC) as an Inflammatory Component of Metabolic Syndrome in Japanese

Oda

Kawai

2010

Intern. Med.

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Section: Drome) (21) Is That It Regards Subcutaneous Adipose Tissue Amentioning

confidence: 99%

Comparison between High-Sensitivity C-Reactive Protein (hs-CRP) and White Blood Cell Count (WBC) as an Inflammatory Component of Metabolic Syndrome in Japanese

Oda

Kawai

2010

Intern. Med.

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“…WBC has been shown to be a clinical marker of inflammation and infection, and is considered an independent predictor of all-cause mortality in a previous report. [13] Increased length of ICU stay is generally associated with increased infection rates, contributing to higher mortality risk and increased cost of illness. [14,15] This study did not, however, show a significant difference in this regard.…”

Section: Discussionmentioning

confidence: 99%

Spectrum of microbial growth and antimicrobial usage in an intensive-care unit of a tertiary-care hospital in Trinidad, West Indies

2017

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Background. Intensive-care units (ICUs) are a source of multidrug-resistant organisms, owing to the indiscriminate usage of broad-spectrum antimicrobial drugs. In such settings, one must be aware of the spectrum of microbes and pattern of antibiotic usage. Objectives. To evaluate the spectrum, susceptibility and resistance patterns of microbes found in ICU patients in a tertiary-care teaching hospital in Trinidad, and to quantify antimicrobial usage. Methods. All adult patients (≥15 years of age) admitted to the ICU for ≥48 h who developed nosocomial infections conforming to the Centers for Disease Control and Prevention criteria were included. Demographic data and clinical data, including specimens sent, isolates grown, antimicrobial sensitivity and resistance patterns, the usage of antimicrobials and patient outcomes, were recorded. Variables such as age, admission white blood cell count, duration of first antibiotic used, length of ICU stay, length of hospital stay, organ support and total comorbidities were analysed. Antimicrobial usage was quantified as the defined daily dosage per 1 000 patient-days. Results. A total of 153 patients with 287 microbiological specimens were studied. The mean patient age was 48.4 years, and the mean ICU length of stay was 7.9 days. The most common admitting diagnoses were sepsis and multiple trauma. Staphylococcus aureus was the most common isolate from blood and central venous lines, and Pseudomonas aeruginosa from tracheal aspirates and wound swabs. Non-survivors had significantly higher age, leucocyte count and organ support requirements, and shorter lengths of stay. Cefuroxime was the most-used antimicrobial in the unit. Conclusion. The usage pattern of antimicrobials did not correlate with susceptibility in most instances. There is a need to improve antimicrobial usage by implementing antimicrobial-stewardship programmes to establish an antimicrobial protocol and guidelines for usage in the ICU.

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“…The details of this cohort have been previously reported 1,2,5,[10][11][12][13][14] . A total of 8,384 community residents (3,504 men and 4,880 women, ≥ 30 years old) from 300 randomly selected districts participated in the survey and were followed until November 15, 2000.…”

Section: Methodsmentioning

confidence: 99%

Relationship between 5-Year Decline in Instrumental Activity of Daily Living and Accumulation of Cardiovascular Risk Factors: NIPPON DATA90

Hayakawa

Okamura

Okayama³

et al. 2010

JAT

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White Blood Cell Count and Risk of All-Cause and Cardiovascular Mortality in Nationwide Sample of Japanese

Cited by 61 publications

References 24 publications

Comparison between High-Sensitivity C-Reactive Protein (hs-CRP) and White Blood Cell Count (WBC) as an Inflammatory Component of Metabolic Syndrome in Japanese

Comparison between High-Sensitivity C-Reactive Protein (hs-CRP) and White Blood Cell Count (WBC) as an Inflammatory Component of Metabolic Syndrome in Japanese

Spectrum of microbial growth and antimicrobial usage in an intensive-care unit of a tertiary-care hospital in Trinidad, West Indies

Relationship between 5-Year Decline in Instrumental Activity of Daily Living and Accumulation of Cardiovascular Risk Factors: NIPPON DATA90

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