“…In terms of clinical symptoms, WMHs are associated with increased cognitive deficits (particularly in executive function and higher-order cognitive functions, such as planning, organizing, and monitoring behaviour) and neurobehavioral and psychiatric problems (e.g., depression, irritability, apathy, anxiety, and agitation), and gait difficulties (Anor et al, 2021; Arvanitakis et al, 2016; Baezner et al, 2008; Dadar et al, 2021, 2020a, 2020c; Kapasi et al, 2017; Misquitta et al, 2020; Srikanth et al, 2010; Teodorczuk et al, 2007; Van Der Flier et al, 2018). Of particular relevance, WMH are known to increase the risk of dementia for the same level of neurodegenerative pathology (Anor et al, 2021; Arvanitakis et al, 2016; Baezner et al, 2008; Dadar et al, 2021, 2020a, 2020c; Kapasi et al, 2017; Misquitta et al, 2020; Srikanth et al, 2010; Teodorczuk et al, 2007; Van Der Flier et al, 2018).…”