White-matter microstructure in previously drug-naive patients with schizophrenia after 6 weeks of treatment

Wang, Qinyu; Cheung, CW; Deng, Wei; Li, M.; Huang, Caili; Ma, Xiaoyan; Wang, Y.; Jiang, Lijun; Sham, Pak C.; Collier, David A.; Gong, Qiyong; Chua, Siew E.; McAlonan, Gráinne; Li, T.

doi:10.1017/s0033291713000238

Cited by 85 publications

(62 citation statements)

References 48 publications

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“…15 Until now, only a handful of longitudinal diffusion studies have been published, examining (short-term) effects of AP medication on microstructural WM (pre-post treatment measurements). [56][57][58][59] The results of the present study were supportive of an effect of (especially the highest) cumulative medication exposure levels on FA change over time, both in within-patients analyses and in between-group analyses based on AP exposure subgroups (with one-third of the patients in each subgroup). However, as the FA change in siblings, who were not using AP medication, was also significantly different from controls, AP exposure may be one of the contributing factors of microstructural WM alteration in patients with psychotic disorder.…”

Section: Methodological Considerationssupporting

confidence: 79%

Differential Time Course of Microstructural White Matter in Patients With Psychotic Disorder and Individuals at Risk: A 3-Year Follow-up Study

Domen¹,

Peeters²,

Michielse³

et al. 2016

Schizophrenia Bulletin

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Section: Methodological Considerationssupporting

confidence: 79%

Differential Time Course of Microstructural White Matter in Patients With Psychotic Disorder and Individuals at Risk: A 3-Year Follow-up Study

Domen¹,

Peeters²,

Michielse³

et al. 2016

Schizophrenia Bulletin

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“…In order to avoid some confounding variables, studies in antipsychotic-naïve FEP patients are of particular interest. Studies in patients never treated with antipsychotics have shown abnormalities in inferior longitudinal fasciculus (Cheung et al, 2008; Liu et al, 2013), superior longitudinal fasciculus (Filippi et al, 2014; Guo et al, 2012; Mandl et al, 2013), cingulum (Wang et al, 2013b), fornix (Filippi et al, 2014; Guo et al, 2012), internal capsule (Guo et al, 2012), uncinate fasciculus (Mandl et al, 2013), genu and splenium (Cheung et al, 2008; Gasparotti et al, 2009), and occipital-frontal fasciculus (Cheung et al, 2008; Liu et al, 2013). …”

Section: Introductionmentioning

confidence: 99%

Abnormal white matter integrity in antipsychotic-naïve first-episode psychosis patients assessed by a DTI principal component analysis

Alvarado-Alanis¹,

León-Ortíz²,

Reyes-Madrigal³

et al. 2015

Schizophrenia Research

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Introduction Diffusion tensor imaging (DTI) studies in patients with schizophrenia have shown abnormalities in the microstructure of white matter tracts. Specifically, reduced fractional anisotropy (FA) has been described across multiple white matter tracts, in studies that have mainly included patients treated with antipsychotic medications. Objective To compare FA in antipsychotic-naïve patients experiencing a first episode of psychosis (FEP) to FA in healthy controls to demonstrate that the variance of FA can be grouped, in a coincidental manner, in four predetermined factors in accordance with a theoretical partition of the white matter tracts, using a principal components analysis (PCA). Methods Thirty-five antipsychotic-naïve FEP patients and 35 age- and gender-matched healthy controls underwent DTI at 3T. Analysis was performed using a tract-based spatial statistics (TBSS) method and exploratory PCA. Results DTI analysis showed extensive FA reduction in white matter tracts in FEP patients compared with the control group. The PCA grouped the white matter tracts into four factors explaining 66% of the total variance. Comparison of the FA values within each factor highlighted the differences between FEP patients and controls. Discussion Our study confirms extensive white matter tracts anomalies in patients with schizophrenia, more specifically, in drug-naïve FEP patients. The results also indicate that a small number of white matter tracts share common FA anomalies that relate to deficit symptoms in FEP patients. Our study adds to a growing body of literature emphasizing the need for treatments targeting white matter function and structure in FEP patients.

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“…Since the scanning duration was about 10 min in this study, head motion is unlikely to be a major source of error. Potential effects of psychotropic medications cannot be fully resolved unless antipsychotic-naïve first-episode subjects are examined (Wang et al, 2013). Controlling for and examining the variance contributed by demographic factors revealed that diffusion measures were still important.…”

Section: Discussionmentioning

confidence: 99%

White matter diffusivity and microarchitecture among schizophrenia subjects and first-degree relatives

Prasad

Upton

Schirda

et al. 2015

Schizophrenia Research

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Background Impairments in structural and functional connections are demonstrated in schizophrenia. Certain disconnectional patterns may be biomarkers of elevated risk for schizophrenia. Convergent examination of multiple diffusion parameters and cognitive performance better illustrates pathophysiological significance of such disconnectional patterns. Methods Diffusion Tensor Imaging data on 39 early-course schizophrenia subjects, 21 adolescent/young adult first-degree relatives (FDR) of schizophrenia subjects and 29 healthy controls (HC) were examined for threshold-free clusters of fractional anisotropy (FA) and radial diffusivity (RD) differences correcting for multiple comparisons. Regression models examined the variance contributed by anisotropy differences, age and sex. Group-wise differences on sustained attention, verbal memory and executive functions were examined and correlated with diffusivity measures controlling for age and sex. Results Schizophrenia subjects showed significantly decreased FA and increased RD in the forceps minor and superior longitudinal fasciculus (SLF) compared to HC. FDR showed decreased forceps minor FA compared to HC, and decreased SLF RD compared to HC and schizophrenia subjects. Quantitative RD differences were 2–3 fold higher compared to FA. Besides, forceps minor RD was inversely correlated with sustained attention in schizophrenia. Conclusions Schizophrenia and FDR subjects show different patterns of white matter diffusivity compared to HC. While forceps minor changes may be a disease marker, SLF changes may be risk markers. In addition, RD may be a more robust risk marker than FA.

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White-matter microstructure in previously drug-naive patients with schizophrenia after 6 weeks of treatment

Abstract: During the early phase of treatment, there is an acute reduction in WM FA that may be due to the effects of antipsychotic medications. However, it is not possible to entirely exclude the effects of underlying progression of illness.

Cited by 85 publications

References 48 publications

Differential Time Course of Microstructural White Matter in Patients With Psychotic Disorder and Individuals at Risk: A 3-Year Follow-up Study

Differential Time Course of Microstructural White Matter in Patients With Psychotic Disorder and Individuals at Risk: A 3-Year Follow-up Study

Abnormal white matter integrity in antipsychotic-naïve first-episode psychosis patients assessed by a DTI principal component analysis

White matter diffusivity and microarchitecture among schizophrenia subjects and first-degree relatives

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