Whole body hypothermia extends tissue plasminogen activator treatment window in the rat model of embolic stroke

Hassanipour, Mahsa; Zarisfi, Mohammadreza; Ehsani, Vahid; Allahtavakoli, Mohammad

doi:10.1016/j.lfs.2020.117450

Cited by 6 publications

(1 citation statement)

References 34 publications

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“…It has been reported that mild hypothermia treatment at 33°C can reduce the oxidative stress damage of PC12 cell lines induced by peroxide (Jayanti et al., 2020). Mild hypothermia improves reperfusion injury and its poor prognosis in ischemic stroke and plays a neuroprotective role (Hassanipour et al., 2020). However, the specific mechanism of mild hypothermia in improving brain injury after ICH is not clear.…”

Section: Introductionmentioning

confidence: 99%

Mild hypothermia improves brain injury in rats with intracerebral hemorrhage by inhibiting IRAK2/NF‐κB signaling pathway

Shi

et al. 2020

Brain and Behavior

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Objective To explore the effect of mild hypothermia on nerve injury by establishing a rat model of intracerebral hemorrhage (ICH), and to clarify the specific molecular mechanism of mild hypothermia in improving brain injury in ICH rats. Methods The rat model of ICH was established by collagenase injection. The neurological deficit score (NDS), brain tissue water detection, and Nissl staining were applied to detect the degree of brain injury. ELISA was used to analyze the expression of proinflammatory cytokines and serum nerve injury indexes. Flow cytometry and Western Blot were used to detect neuronal apoptosis. Results Mild hypothermia treatment significantly improved the brain injury of the ICH rats and down‐regulated the inflammatory response and oxidative stress in the brain tissue. Moreover, mild hypothermia also effectively inhibited IRAK2/NF‐κB signaling pathway and thus affect neuronal apoptosis. Conclusion Mild hypothermia alleviates inflammatory response and neuronal apoptosis by inhibiting IRAK2/NF‐κB signaling pathway in the ICH rats thus improving brain injury.

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Section: Introductionmentioning

confidence: 99%