"Antibiotics alone" remains today the guiding principle of the treatment of many inflammatory diseases including acute pneumonia (AP). If this principle of treatment has produced the expected results, the discussion of this topic would not be required. Therefore, the published results show not only the negative dynamics of development of purulent complications of the AP, but also the lack of promising strategies to address this problem [1][2][3][4]. "Pediatric pleural empyema has increased substantially over the past 20 years and reasons for this rise remain not fully explained" [5]. In developed countries from 9.5% to 42% of patients with pneumonia are received in the hospital due to the ineffectiveness of primary treatment [6]. However, the transfer of patients to hospital does not improve the results of treatment. "Parapneumonic effusions or empyema affect 2 to 12% of children with pneumonia, and up to 28% of those requiring hospitalization" [7].Unfortunately, the modern scientific explanation and recommendations for treatment of АP and prevention of its complications direct practical medicine only to suppress microflora. Therefore, the main, and in many patients, the only means of treatment are antibiotics. Such recommendations for certain time periods based on the allegations of a predominant participation of specific bacteria in the development of АР. In recent years, this bogey was Streptococcus pneumoniae. However, the well-known facts and results do not confirm the specificity of the etiology of АP. Most of the patients with AP heals without any verification of the etiology of the disease. Therefore, discussions on the etiology of inflammation in these patients in the absence of concrete results is simply groundless. Bacteriological examination of material from the zone of inflammation becomes available in case of purulent complications. Only the results of these studies indicate the participation of the most diverse microflora. Scientific medicine has received the most serious blow to its reputation after years of total pneumococcal vaccination of the population in developed countries. So, a statistically significant increase in suppurative complications AP, contrary to the prediction of decline, is still without a proper scientific explanation. "Among children ≤ 18 years of age, the annual empyema-associated hospitalization rates increased almost 70% between 1997 and 2006, despite decreases in the bacterial pneumonia and invasive pneumococcal disease rates. Pneumococcal conjugate vaccine is not decreasing the incidence of empyema" [8]."Despite decrease in pneumococcal diseases among Utah children, complicated pneumonia/empyema has increased during the 7-valent pneumococcal conjugate vaccine era". "The causes on increasing rates of empyema are unclear" [9].The discovery of antibiotics was outstanding achievement in the past century. Their practical applications have saved the lives of a huge number of patients. Therefore, the importance of antibiotics in complex medical care to various categories of pa...