Why the cornea swells

Hodson, Stuart

doi:10.1016/0022-5193(71)90090-7

Cited by 63 publications

(51 citation statements)

References 17 publications

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“…The details of this analysis are given in the Appendix. We have assumed that the swelling pressure is totally Donnan-osmotic in origin, and that its value is as calculated by Hodson (1971). This swelling pressure causes water to flow into the stroma, and in calculating the flow we have used the experiments and calculations of Hedbys & Mishima (1962) .…”

Section: Effects Away From the Isoelectric Pointmentioning

confidence: 99%

“…It is also of interest that the pH dependence of the swelling rate at /z = 0-1 is very small. Presumably the stroma is specialized to give a swelling pressure which while finite is small and relatively independent of /u and pH near to physiological conditions, so that the ion pumping mechanism which opposes the swelling (Hodson, 1971) works in a stable environment. Other features of Figs 10 and 11 probably relate to ion-binding to the protein which we will consider in section IV below.…”

Section: Effects Away From the Isoelectric Pointmentioning

confidence: 99%

“…This is equivalent to eq. (10) in Hodson, 1971. R is the gas constant (8.314 J.Kmol') and T is the absolute temperature, assumed to be 293 K. The expression under the square root in this equation can be expanded using the binomial theorem to give a simpler relationship between the osmotic pressure difference and the fixed charge concentration.…”

Section: General Conclusionmentioning

confidence: 99%

“…On this assumption the contributions to the swelling pressure include the Donnan-osmotic effect, stretching of the glycosaminoglycan chains, excluded-volume effects and the interaction of the glycosaminoglycans with the solvent. On the other hand, Hodson (1971) supposed that no effective cross-links exist in the cornea; he suggested that the glycosaminoglycan molecules surround the collagen fibrils (Hodson & Meenan, 1969;Myers, Highton & Rayns, 1973). In Hodson's model, the swelling pressure is held to be due entirely to the Donnan-osmotic pressure between the stroma and the external solution.…”

Section: Introductionmentioning

confidence: 99%

“…Otori (1967) calculated that the fixed charge concentration is 36 mm in fresh tissue, from the data of Anseth & Laurent (1961). However, Hodson (1971) states that the fixed charge concentration is more likely to be 48 mM when all the charged groups, carboxyl as well as sulphonic acid groups, are included in the calculation. He obtained an experimental value of 47.4 mm using the Donnan exclusion techniques of Maroudas & Thomas (1970).…”

Section: Introductionmentioning

confidence: 99%

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Swelling studies of bovine corneal stroma without bounding membranes.

Elliott¹,

Goodfellow²,

Woolgar³

1980

The Journal of Physiology

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SUMMARY1. The swelling characteristics of demembranated bovine corneal stroma were studied as a function of time and of the pH and ionic strength of the bathing solution.2. Compared with other pH values, the stroma swelled least near pH 4. 3. In the pH range 6-10, increasing the pH resulted in an increase both in the rate of swelling and in the hydration reached in a given time.4. At pH 2 and 4, a final constant value of hydration was attained. At higher pH values no such equilibrium was attained when the hydration of the tissue was followed for at least 100 hr.5. The swelling at high pH values was consistent with the hypothesis that the Donnan-osmotic contribution is the major component of the swelling pressure.6. The ionic strength dependence was complex. There was a general decrease of swelling with increase in the ionic strength (iu) until around /t = 0-1. The swelling at u=0-15 was greater than at /= 0-1 and 1z = 0-25. 7. The results were interpreted on the assumption that the Donnan-osmotic effect is the major component of the swelling pressure.

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Section: Effects Away From the Isoelectric Pointmentioning

confidence: 99%

Section: Effects Away From the Isoelectric Pointmentioning

confidence: 99%

Section: General Conclusionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Swelling studies of bovine corneal stroma without bounding membranes.

Elliott¹,

Goodfellow²,

Woolgar³

1980

The Journal of Physiology

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Physiological Chemistry of the Eye

Gw¹

1973

Archives of Ophthalmology

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Swelling of articular cartilage and other connective tissues: Electromechanochemical forces

Eisenberg

Grodzinsky

1985

Journal Orthopaedic Research

231

145

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We have measured the relationship between tissue swelling stress and consolidation for bovine articular cartilage and corneal stroma in uniaxial confined compression as a function of bath ionic strength. Our experimental protocol and results clearly demonstrate that two concentration-dependent material properties are necessary to describe the chemical dependence of tissue swelling stress in uniaxial compression over the range of deformations and concentrations explored. A general electromechanochemical model for the swelling stress of charged connective tissues is developed. The model focuses on the role of charged matrix macromolecules in determining the mechanical behavior of the tissue. A constitutive relation for the swelling stress in uniaxial confined compression is formulated and the concentration dependence of the material properties of articular cartilage and corneal stroma is determined. The associated free swelling behavior of cartilage and cornea specimens is computed from these results and is found to compare favorably with data from the literature.

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Why the cornea swells

Cited by 63 publications

References 17 publications

Swelling studies of bovine corneal stroma without bounding membranes.

Swelling studies of bovine corneal stroma without bounding membranes.

Physiological Chemistry of the Eye

Swelling of articular cartilage and other connective tissues: Electromechanochemical forces

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