Widespread vitamin D insufficiency: A new challenge for primary prevention, with particular reference to multiple sclerosis

Pierrot‐Deseilligny, Charles; Souberbielle, Jean‐Claude

doi:10.1016/j.lpm.2011.01.003

Cited by 28 publications

(15 citation statements)

References 68 publications

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“…Females aged 15–45 years are at a greater risk of 25(OH)D 3 deficiency, especially in combination with seasonal variations. The peak of incidence is noted between the third and the fourth decades of life [8, 9]. …”

Section: Introductionmentioning

confidence: 99%

Calcium–phosphate metabolism in patients with multiple sclerosis

Kubicka-Bączyk

Łabuz-Roszak

Pierzchała

et al. 2015

J Endocrinol Invest

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Introduction and objectivesThe purpose of this study was to evaluate the concentration of 25-hydroxycholecalciferol and parameters of calcium–phosphate metabolism at different periods of relapsing–remitting multiple sclerosis (RRMS).Materials and methodsForty-five patients, residents of Poland (49°–50°, N), were enrolled in the study, i.e. 15 immediately after the diagnosis of RRMS, 15 at the early stage and 15 at the advanced stage of RRMS. The results were compared to values obtained in 20 age- and sex-matched controls.ResultsLower serum concentrations of 25-hydroxycholecalciferol and ionised calcium were found in patients compared to the control group. In patients with the disease duration of 5–6 years, concentrations of 25-hydroxycholecalciferol and ionised calcium were lower than in patients in the earlier period of RRMS. The inverse and clearer direction of changes was found in parathormone serum concentration in patients compared to the controls. In patients with a longer disease duration, a significantly lower 25-hydroxycholecalciferol concentration was found in female patients compared to male patients. In patients, more frequent 25-hydroxycholecalciferol and unsaturated fatty acids’ supplementation was observed compared to the controls.ConclusionsIn RRMS patients, calcium–phosphate metabolism is disturbed which increases during disease progression.

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Section: Introductionmentioning

confidence: 99%

Calcium–phosphate metabolism in patients with multiple sclerosis

Kubicka-Bączyk

Łabuz-Roszak

Pierzchała

et al. 2015

J Endocrinol Invest

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“…Serum 25(OH)D levels have been found inversely correlated with incidence of MS [12], as has vitamin D intake in adolescence [13]. The evidence that vitamin D reduces the risk of MS is considered strong [14].…”

mentioning

confidence: 99%

Evidence that the north–south gradient of multiple sclerosis may not have disappeared

Grant

Mascitelli²

2012

Journal of the Neurological Sciences

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“…The optimal serum level of vitamin D is 75-250 nmol/l (30-100 ng/ml). In countries with less sunny climate, the necessary daily dose of vitamin D is 1000-4000 IU/day (1 μg = 40 IU) [86].…”

Section: Serum Level Of Vitamin D and Dose Managementmentioning

confidence: 99%

Genetic and Biochemical Factors Related to the Risk and Disability Progression in Multiple Sclerosis

Čierný¹,

Michalík²,

Kantorová³

et al. 2016

Trending Topics in Multiple Sclerosis

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Sclerosis multiplex (multiple sclerosis, MS) is a chronic autoimmune inflammatory disease of the central nervous system. The immune regulatory defects lead to the process of inflammation and neurodegenerationthat results in the deterioration of neurological functions. It is still unclear as to why MS is so devastating and rapidly progressive in one patient and less so in another. It is known that the etiopathogenesis of MS is very complex, and many factors can be involved in the risk and character of the disease and its progression. In this chapter, we discuss the general molecular and cellular mechanisms of action of genetic and biochemical factors that are related to immune system regulation and thus can be connected to the individually varying risk and disability progression of MS. We found that gene variants of the gene polymorphism rs6897932 in interleukin 7 receptor α chain gene rs10735810 in vitamin D receptor gene and HLA-DR and HLA-DQ genes as well as the serum level of vitamin D are associated with MS risk or disability progression in Central European Slovak population.

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Widespread vitamin D insufficiency: A new challenge for primary prevention, with particular reference to multiple sclerosis

Cited by 28 publications

References 68 publications

Calcium–phosphate metabolism in patients with multiple sclerosis

Calcium–phosphate metabolism in patients with multiple sclerosis

Evidence that the north–south gradient of multiple sclerosis may not have disappeared

Genetic and Biochemical Factors Related to the Risk and Disability Progression in Multiple Sclerosis

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