The electronics industry is mainly driven by the demand for smaller, faster, higher complexity, more reliable and cheaper device. Reduction in bond pad patch and low K wafer were introduced into mass production for miniaturation and signal transmission integrity. High safety requirement and longer working life demand high reliability performance especially in automotive and aerospace filed. Although trends in electronic packing have been focused on the development of flip chip, Wire bonding still cements its position in chip interconnection technology. In IC assembly, gold wire is the key material in wire bonding process to connect chip to substrate. 2N gold wire with specific dopant is applied in many types of package for stringent reliability requirement field. This study will focus on 2N gold wire application in wire bonding process.Bonding wire, bonding capillary, and wire bonding parameters, was selected as critical factors in this study. This paper describes the key 1st bond parameter optimization on CMOS90 low K device. Gold wire and capillary design were studied. Tail scrubs function of KNS maxum plus wire bonder was also studied to find out how to produce robust 2nd bond. The Newly-designed capillary from SPT aimed to improve wire stitch pull strength was also studied to improve 2N gold wire 2nd bond stitch bond which have weak stitch bond strength result from its big hardness. Critical responses such as Ball size, Ball height bonded ball diameter ratio, bonded ball placement, wire pull strength, ball shear strength, and stitch pull strength were studied to understand the wire bonding effect of low k device. DOE (Design of Experiment) and RSM (response surface methodology) was used to optimize the wire bond process. Thermal aging test coupled with wire pull and ball shear test with recording failure mode were studied. The IMC (Inter Metallic Coverage) of the Au-Al and cratering were also tested.The combination of the low K material and harder 2N wire introduction leaves a narrow process window for packaging assembly, and raises challenges to wire bonding process in terms of process manufacturability. The studies showed that 2N wire were found to be a good replacement of traditional 3N wires on improving bonding integrity of the low K device. Capillary geometry design is also critical to achieve a better IMC coverage, robust 2nd bond. The newly-designed capillary from SPT aimed to improve 2N wire stitch pull strength.