Due to the varieties of services and the openness of network architectures, great challenges for information security of the 5G systems are posed. Although there exist various and heterogeneous security communication mechanisms, it is imperative to develop a more general and more ubiquitous authentication method for data security. In this paper, we propose for the 5G networks a novel multimedia authentication framework, which is based upon the trusted content representation (TCR). The framework is general and suitable for various multimedia contents, e.g., text, audio, and video. The generality of the framework is achieved by the TCR technique, which authenticates the contents' semantics in both high and low levels. Analysis shows that the authentication framework is able to authenticate multimedia contents effectively in terms of active and passive authenticating ways.