Wissenswertes für die Pharmazeutische Praxis. Über einige Fragen der Homogenität der im Gießverfahren hergestellten Suspensionszäpfchen

Influence of dynamic interfacial tension on droplet formation during membrane emulsification

“…Nevertheless, the results for an oil pressure of 0.67 bar and concentrations of 0.1-3% Tween 20, for which the oil rate of flow is constant, show a clear decrease in droplet diameter, therewith signifying the conclusion that interfacial tension is the predominant mechanism. Please note that the effects can be partly attributed to the increase in viscosity [11] of the continuous phase at high surfactant concentration which is inherent to the system. A higher rate of flow and higher velocity in the pore can be obtained at higher oil pressure; however, larger droplets will also be formed.…”

Pharmaceutical Sciences—1963. Part I.

“…Experimental work was published on micelle formation by surfactants and its importance in the solubilization of drugs (541,542). Several investigators reported on micelle formation and critical micelle concentration (CMC) of some betaine derivatives under a variety of conditions (543-546).…”

Correlations between Physical and Drug Release Characteristics of Polyethylene Glycol Suppositories

“…Rheological investigations of suppository bases have been confined to the molten or semisolid state (21)(22)(23)(24)(25) and determinations of "hardness" of the solid bases (4,(26)(27)(28)(29). Baichwal and Lohit (25) ob- served that drug release from cocoa butter (theobroma) bases was inversely related to the consistency, expressed as a viscosity index.…”