With which component of the bovine isolated cornea does sodium lauryl sulphate react to produce opacity?

Igarashi, Haruyoshi

doi:10.1016/0378-4274(86)90115-3

Cited by 18 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present study showed that sodium lauryl sulfate and chlorhexidine digluconate are not compatible in vivo when applied subsequently and at concentrations used for clinical purposes. Both compounds will attach to oral tissues (RoHa et al 1970, 1971, BonesvoU et al 1977, Barkvoll et al 1988b, 1988c, Igarashi 1986), both will bind to and denature proteins (R0lla et al 1970(R0lla et al , Tzutzumi et al 1982. There is reason to believe that a salt with low solubility and low antibacterial activity was formed in vivo, neutralizing chlorhexidine, even when the agents were applied separately and with time intervals.…”

Section: Discussionmentioning

confidence: 99%

Interaction between chlorhexidine digluconate and sodium lauryl sulfate in vivo

Barkvoll

Rölla

Svendsen

1989

J Clinic Periodontology

150

115

View full text Add to dashboard Cite

Chlorhexidine (CH) is cationic and it forms salts of low solubility with anions such as phosphate, sulfate and carboxyl. Toothpastes contain anionic detergents, one of the most widely used being sodium lauryl sulfate (SLS). The aim of the present study was to examine the possible interaction between CH and the anion SLS in vivo. The interference of SLS on the antiplaque potential of CH was investigated. The study was performed according to a single blind cross over design, and the effect of the interval between prerinsing with an aqueous solution of SLS and the subsequent rinsing with CH was examined. The antiplaque effect was examined by the use of the Silness and Löe plaque-index. The results showed that even a 30-min interval between SLS- and CH-rinsing gave a significantly reduced antiplaque effect of CH, whereas the neutralizing effect of SLS disappeared after 2 h. It can thus be concluded that SLS is not compatible with CH, even when these compounds are introduced separately in the oral cavity. The time between toothbrushing and a CH rinse should at least be 30 min, if a reduction in the antimicrobial effect is to be avoided.

show abstract