Withanolides from Physalis peruviana

Ahmad, Saeed; Malik, Abdul; Yasmin, Riffat; Ullah, Nisar; Gul, Waseem; Khan, Pir Muhammad; Nawaz, Hafiz Rub; Afza, Nighat

doi:10.1016/s0031-9422(98)00567-6

Cited by 56 publications

(42 citation statements)

References 8 publications

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“…Furthermore, we isolated 14β-hydroxywithanolides (3 and 4), which are also rare. 31,42) The withanolides isolated from W. coagulans were tested for leishmanicidal activity against L. major proamastigotes. The results are shown in Table 3.…”

Section: Resultsmentioning

confidence: 99%

Leishmanicidal Active Withanolides from a Pakistani Medicinal Plant, <i>Withania coagulans</i>

et al. 2012

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Key words Withania coagulans; Solanaceae; withanolide; leishmanicidal activityLeishmaniases are a group of tropical diseases caused by infections of a number of species of protozoan parasites belonging to the genus Leishimania that survive and multiply in macrophages in the mammalian host. The parasites are transmitted by female flying insects of the genera Phleobotomus and Lutzomyia. Leishmaniases currently affect 12 million people in developing countries annually.1,2) In many cases, medicines employed for treatment are toxic, only slightly effective, given by injection, or compromised by the development of resistance.3) Therefore, safe, effective, and affordable medicines for leishmaniases are needed in developing countries. There have been many studies on leishmanicidal compounds in plants, [4][5][6][7] but there are as yet no safe effective, and reasonably priced medicines. In the course of our study on leishmanicidal agents, sesquiterpene lactone, 8) steroid saponins, 9) and novel neolignans 10) were isolated. While screening of tropical plants for leishmanicidal compounds, we found that a Pakistani medicinal plant, Withania coagulans, showed activity. A number of interesting steroids called withanolides have been isolated from Withania spp. plants belonging to Solanaceae. [11][12][13] Withanolides are C28 steroids based on an ergostane skeleton having characteristic functional groups, 14) and have also been isolated from several Solanaceae plants, such as Physalis, 15,16) 25,26) Withanolides were reported to have various interesting biological activities, such as antitumore activity, 16,27,28) cell differentiative activity, 29) neurite outgrowth activity, 30) trypanocidal activity, 31) apoptosis activity and inhibition of invasion, 32) and anti-feedant activity. 33) We tried to isolate leishmanicidal compounds from the aerial parts of W. coagulans collected in Pakistan. This paper reports the isolation of four new withanolides along with seven known withanolides from the ethyl acetate (EtOAc)-soluble fraction of the plants, their structural elucidation, and their leishmanicidal activity.

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Section: Resultsmentioning

confidence: 99%

Leishmanicidal Active Withanolides from a Pakistani Medicinal Plant, <i>Withania coagulans</i>

et al. 2012

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“…The genus Physalis, which belongs to the family Solanaceae, includes about 120 species mainly distributed in Mexico, Europe, and Southeast and Central Asia (Ahmad et al, 1999;Perez-Castorena et al, 2004). Some of them (i.e.…”

Section: Introductionmentioning

confidence: 99%

“…P. peruviana, commonly known as "cape gooseberry" or "goldenberry," is a tropical plant bearing orange edible fruits. The plant has been used in East and Southeast Asian folk medicine for treating cancer, leukemia, hepatitis, rheumatism, and other diseases (Ahmad et al, 1999;Ramadan & Mörsel, 2003;Wu et al, 2004). P. philadelphica has been used for the treatment of gastrointestinal disorders in Guatemala, and for treating leprosy, purifying the blood, and as a poison antidote in Mexico.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of the extracts and physalin D fromPhysalis alkekengiand evaluation of antioxidant potential of physalin D

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Kawai

et al. 2009

Pharmaceutical Biology

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“…Key words: Solanaceae, Physalis, inflammation, anti-inflammatory agents, plants, medicinal Physalis es un importante género de la familia Solanaceae; cuenta con cerca de 120 especies que se distribuyen a través de las regiones tropicales y subtropicales del mundo, encontrándose principalmente en América, con un pequeño número de especies en Europa y en los países del suroriente y centro de Asia (1,2). Physalis peruviana L., denominada comúnmente en Colombia como uchuva (Cape gooseberry), es una de las especies más conocidas de este género y es ampliamente utilizada en la medicina tradicional como anticancerígeno, antimicobacterial, antipiré-tico, diurético, inmunomodulador y para el tratamiento de enfermedades como malaria, asma, hepatitis, dermatitis y artritis reumatoide (3).…”

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“…Physalis peruviana L., denominada comúnmente en Colombia como uchuva (Cape gooseberry), es una de las especies más conocidas de este género y es ampliamente utilizada en la medicina tradicional como anticancerígeno, antimicobacterial, antipiré-tico, diurético, inmunomodulador y para el tratamiento de enfermedades como malaria, asma, hepatitis, dermatitis y artritis reumatoide (3). Los extractos de las hojas de esta planta han mostrado importantes actividades antibióticas, antioxidantes y antinflamatorias (1,3,4). Los estudios fitoquímicos de este género han demostrado la presencia de witanólidos, esteroides, alcaloides, glicósidos y flavonoides (2,5-7).…”

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Actividad antinflamatoria de extractos y fracciones obtenidas de cálices de Physalis peruviana L.

et al. 2007

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Introducción. Los cálices de la uchuva, Physalis peruviana, son ampliamente utilizados en la medicina popular por sus propiedades como anticancerígeno, antimicobacterial, antipirético, diurético, immunomodulador y antinflamatorio. Objetivo. Evaluar el efecto antinflamatorio de extractos y fracciones obtenidas de los cálices de Physalis peruviana en un modelo de inflamación aguda en ratón, procurando identificar las fracciones responsables de dicha actividad. Materiales y métodos. Los cálices de Physalis peruviana fueron extraídos por percolación con solventes orgánicos. La fracción primaria hidroalcohólica se purificó mediante cromatografía en columna. La actividad antinflamatoria de los extractos y fracciones se evaluó utilizando el modelo murino de edema auricular inducido por 13-acetato de 12-tetradecanoilforbol. Resultados. Se obtuvieron 38 fracciones secundarias en la cromatografía en columna de la fracción primaria hidroalcohólica, de las cuales seis fueron evaluadas en el modelo inflamatorio, mostrando actividad significativa (p<0,05). La fracción mayoritaria identificada como Pp-D 28 -LF presentó una respuesta dosis dependiente con significativa inhibición del edema en dosis superiores a 250 µg/oreja (p<0,05). Conclusión. Este estudio confirma la actividad antinflamatoria atribuida a los cálices de Physalis peruviana y también valida su uso en la medicina popular. Se identificaron las principales fracciones responsables de la actividad antinflamatoria, las cuales parecen ser promisorias para el desarrollo de fitopreparados. Se requieren estudios posteriores para aislar e identificar los compuestos responsables de la actividad y también para investigar el mecanismo involucrado en el efecto antinflamatorio observado.Palabras clave: Solanaceae, Physalis, inflamación, agentes antinflamatorios, plantas medicinales. Antiinflammatory activity of extracts and fractions obtained from Physalis peruviana L. calycesIntroduction. Cape gooseberry calyces (Physalis peruviana) have been used in folk medicine for their medicinal properties including anticancer, antimycobacterial, antipyretic, diuretic, immunomodulatory and antiinflammatory properties. Objective. The antiinflammatory effect was evaluated for extracts and fractions obtained from Physalis peruviana calyces in a mice model of acute inflammation. The fractions responsible for antiinflammatory activity were extracted for possible identification. Materials and Methods. The Physalis peruviana calyces were extracted by percolation with organic solvents. The primary hydroalcoholic fraction was purified by column chromatography. The antiinflammatory effect of extracts and fractions was evaluated using the 12-Otetradecanoylphorbol-13-acetate-induced mouse model of ear edema. Results. Thirty-eight secondary fractions were obtained by column chromatography of primary hydroalcoholic fraction. Six fractions, evaluated in 12-O-tetradecanoylphorbol-13-acetateinduced inflammation assay, showed significant antiinflammatory activity (p<0.05). The major

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Withanolides from Physalis peruviana

Cited by 56 publications

References 8 publications

Leishmanicidal Active Withanolides from a Pakistani Medicinal Plant, <i>Withania coagulans</i>

Leishmanicidal Active Withanolides from a Pakistani Medicinal Plant, <i>Withania coagulans</i>

Antimicrobial activity of the extracts and physalin D fromPhysalis alkekengiand evaluation of antioxidant potential of physalin D

Actividad antinflamatoria de extractos y fracciones obtenidas de cálices de Physalis peruviana L.

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