Wnt Signaling Regulates Neuronal Differentiation of Cortical Intermediate Progenitors

Development of the hypothalamus: conservation, modification and innovation

“…There are two alternate interpretations of this finding: either Wnt-responsive cells are postmitotic committed progenitors poised for differentiation or, as in the cortex (Munji et al, 2011;Gan et al, 2014), they are progenitor cells that can re-enter the cell cycle and divide symmetrically or asymmetrically. The latter possibility offers a potentially novel mechanism for hypothalamic neurogenesis, and these scenarios can be resolved experimentally by performing lineage tracing, for instance by using inducible Cre recombination driven in Wnt-responsive cells (Bowman et al, 2013).…”

Canonical and noncanonical Wnt signaling in neural stem/progenitor cells

“…In the nervous system, Wnt-3a knockout (KO) mice exhibit under-development of the hippocampus, as a result of a reduction in proliferation [42]. In contrast to this, ectopic expression of Wnt-3a induces the differentiation of intermediate cortical progenitors during mid-and late-cortical neurogenesis [43]. These contradictory findings show that one Wnt ligand can have different outputs depending in the cellular context: given that these molecules can compete with each other, other agonists and antagonists, and that they can interact with a wide range of receptors and co-receptors, it is not surprising that they can exert such different effects on developing cortical and hippocampal precursors.…”

“…Wnt-1 KO Altered central and peripheral neuronal development during initial axonogenesis [54] Wnt-1 KO Impaired midbrain development [55] Wnt-1 dominant negative Impaired hippocampal neurogenesis and spatial and object recognition memory [56,57] Wnt-1 overexpression Reduced neural differentiation of mESCs (also by treatment with lithium chloride) [58] Wnt-1 KO Increased differentiation into DA neurons in KO mESCs [59] Wnt-2 KO Decreased progenitor proliferation and neurogenesis in the ventral midbrain [60] Wnt-2 overexpression Induced dendritic arborization in hippocampal progenitors [61] Wnt-3 overexpression Increased differentiation of cortical intermediate [43] progenitors Wnt-3 overexpression Induced differentiation through cleavage of RYK in cortical progenitors [62] Wnt-3a KO Loss of the hippocampus [42] Recombinant Wnt-3a Induced GABAergic neuronal differentiation through RYK, reduced oligodendrogenesis [63] Recombinant Wnt-3a Induced differentiation of hESCs [64] Recombinant/purified Wnt-3a…”

Anti–viral effects of curcumin on influenza A virus–induced myocarditis via inhibiting Wnt/β–catenin signaling

“…Recently, a systemic profiling has shown that Wnt/β-catenin signaling pathway may play an important role in influenza replication in primary human bronchial epithelial cells [12]. Wnt/β-catenin signaling pathway is a multifunctional pathway, which is crucial for embryonic heart development and cardiovascular disease [13][14][15]. However, there is no direct evidence of the molecular relationship between influenza A virus and Wnt/β-catenin signaling on pathogenesis of VMC caused by influenza virus infection.…”