Wnt/β-catenin antagonist pyrvinium rescues high dose isoproterenol induced cardiotoxicity in rats: Biochemical and immunohistological evidences

Pleiotropic attenuating effect of Ginkgo biloba against isoprenaline-induced myocardial infarction via improving Bcl-2/mTOR/ERK1/2/Na+, K+-ATPase activities

“…Significantly, ISO-exposed animals had higher level of cardiac MDA whereas receiving GBE treatment resulted in a notable reduction in lipid peroxidation, thus enhancing the cardio protective function. The findings of our study also demonstrated a significant increase in cardiac nitrite levels in ISO-treated rats, indicating a dysregulation of nitric oxide signalling that may further contributed to the animals’ poor cardiovascular performance ( Srivastava et al, 2022 ). Accordingly, NO was thought to mediate glutamatergic excitotoxicity via synergistic and cooperative release of glutamate and inflammatory cytokines like TNF-α by cardiac cells, thereby creating a favourable environment that exacerbated cardiac damage and heart failure ( Ben-Azu et al, 2022 , Asiwe et al, 2022b , Asiwe et al, 2024 ).…”

Pyrvinium Pamoate: Past, Present, and Future as an Anti-Cancer Drug

“…Although the use of PP as an anthelminthic has dwindled over the years, since the early 2000s, interest in PP has surged due to its potential utilization to target other diseases-causing organisms at every level from viral [ 27 , 28 ] through bacterial [ 29 , 30 , 31 ], plasmodium [ 32 ], and fungi [ 33 , 34 , 35 ] to multicellular organisms [ 36 ] ( Figure 2 ). PP has also shown significant potential in multiple disease types for the ability to reduce toxicity, promote wound repair, and inhibit fibrotic tissue development [ 37 , 38 , 39 , 40 , 41 , 42 ]. Perhaps most importantly, PP has received significant interest from cancer researchers due to its ability to target multiple types of human cancers, in particular cancer stem cells.…”

The role of β-catenin in cardiac diseases

“…Overexpression of β-catenin in cardiac myocytes could lead to cell volume increases, actin formation, pathological hypertrophy marker (kinase p38, JNK1/2, ERK1/2, ERK5) activation, and ANP and BNP increases ( Lee et al, 2017 ). Knockout or inhibition of myocardial β-catenin reduced MH ( Srivastava et al, 2022 ). After the slow administration of Ang II in mice, eight Wnt ligands in the heart were upregulated, and the Wnt/β-catenin pathway was activated ( Zhao et al, 2018 ).…”