Women age ≤ 35 years with primary breast carcinoma

González-Angulo, Ana M.; Broglio, Kristine; Kau, Shu Wan; Eralp, Y.; Erlichman, Julie; Valero, Vicente; Theriault, Richard L.; Booser, Daniel J.; Buzdar, Aman U.; Hortobágyi, Gabriel N.; Arun, Banu K.

doi:10.1002/cncr.21070

Cited by 80 publications

(45 citation statements)

References 24 publications

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“…These results are substantiated by a recent study from investigators at the MD Anderson Cancer Center, showing that among very young breast cancer patients (p35 years), a family history of ovarian cancer strongly impaired disease-free and overall survival (Gonzalez-Angulo et al, 2005). Nevertheless, the low number of cases prevented us from drawing definite conclusions and the results should be used only to generate hypotheses.…”

Section: Discussionmentioning

confidence: 61%

“…Some studies have shown improved survival rates among breast cancer patients with affected relatives compared to those without a family history (Malone et al, 1996;Mohammed et al, 1998), some reported poorer survival rates (Slattery et al, 1993;Gonzalez-Angulo et al, 2005), and others did not find any survival difference between patients with or without a family history (Greenberg et al, 1985;Kinoshita et al, 2004). Although most of these studies used multivariate analysis to adjust mortality risks for other prognostic variables, none of them adjusted for use of systemic therapy.…”

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confidence: 99%

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Impact of familial risk factors on management and survival of early-onset breast cancer: a population-based study

et al. 2005

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This population-based study evaluates the impact of a strong family history of breast cancer on management and survival of women with early-onset disease. We identified all breast cancer patients p50 years, recorded between 1990 and 2001 at the Geneva familial breast cancer registry. We compared patients at high familial risk and low familial risk in terms of tumour characteristics, method of detection, treatment, survival and breast cancer mortality risk. Compared to patients at low familial risk (n ¼ 575), those at high familial risk (n ¼ 58) received significantly more often systemic therapy, especially for node-negative or receptor-positive disease. Five-year disease-specific survival rates of patients at high vs low familial risk were 86 and 90%, respectively. After adjustment, there was no difference in breast cancer mortality in general. A strong family history nonsignificantly increased breast cancer mortality in patients p40 years (adjusted hazard ratio (HR) 4.0, 95% CI 0.8 -19.7) and in patients treated without chemotherapy (adjusted HR 2.7, 95% CI 0.6 -12.5). A strong family history of breast cancer is associated with an increased use of systemic therapy in early-onset patients. Although a strong family history does not seem to affect survival in general, it may impair survival of very young patients and patients treated without adjuvant chemotherapy. Owing to the limited number of patients in this study, these results should be used only to generate hypotheses.

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Section: Discussionmentioning

confidence: 61%

mentioning

confidence: 99%

Impact of familial risk factors on management and survival of early-onset breast cancer: a population-based study

et al. 2005

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“…Given the delayed diagnosis, ~75% of these cancer cases are diagnosed at an advanced stage, with 50-80% lymph node involvement and higher SBR grading (40% SBR 2 and 50% SBR 3). Hormone receptors are less likely to be positive (68% of those <40 years of age vs. 80% of ≥40 years), and HER2 is more frequently over expressed in younger patients than in postmenopausal females (19,20). Triple-negative tumors (negative for ER, PR and HER2) are more common in younger patients (21).…”

Section: Discussionmentioning

confidence: 99%

Breast cancer cases of female patients under 35ï¿½years of age in Togo: A series of 158ï¿½cases

et al. 2017

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Abstract. Breast cancer in young female patients represents a public health problem in developing countries. The objectives of the study were to study the epidemiological and histological characteristics of breast cancer in female patients under 35 years of age. This was a retrospective analytical study of a series of 158 cases of breast cancer in female patients under 35 years of age, conducted at the University Teaching Hospital of Lomé between 2000 and 2015. A total of 158 cases were collected, representing 36.2% (436) of all breast cancer cases. The average age of the patients was 30.9 years (range, 16-35 years). A family history of breast cancer at the 1st or 2nd degree was identified in 13.9% of cases. Genetic mutation studies were carried out for 7 patients, 5 of which revealed mutations (4 BRCA1 and 1 BRCA2). According to the locus, the cancer was located preferentially in the left breast in 88 cases (55.7%). Malignant mammary lesions were epithelial tumors (n=144 cases, 91.1%), infiltrating (n=125 cases, 79.1%) and non-infiltrating (n=19 cases, 12.0%). The other histological groups consisted of 8 cases of sarcomas (5 cases of angiosarcoma, 2 cases of fibrosarcoma and 1 case of Kaposi's sarcoma), 5 cases of lymphomas and one case of melanoma. Not otherwise specified infiltrating ductal carcinomas were SBR II and III in 43.2 and 35.2% of cases, respectively. The tumors classified as T4 were the most frequent (30.4%). Regarding the lymph node status, lymph node metastasis was noted in 22.8% of cases. Studies of hormone receptors were carried out in 23 patients and were positive for 11 patients: Estrogen receptor (ER)+plus progesterone receptor (PR)+(7 patients), ER+PR-(4 patients). Of the aforementioned 8 cases of sarcoma, 5 were angiosarcoma. The lymphomas were predominantly Burkitt's type for 4 cases. Mammary ultrasonography was performed in 45.6% of the patients and 54.4% underwent the combined ultrasonography and mammography. Ultrasound identified one or more sign of malignancy in 67 patients (42.4%), and combined ultrasonography and mammography classified 51.9% of lesions in BIRADS 4 and 5. The incidence of breast cancer in young Togolese patients is high. It is a disease distinguished by a delay in diagnosis, which contributes to the high number of cases that initially diagnosed at an advanced stage, particularly the high histo-prognosis grades of infiltrating ductal carcinoma. These results indicate a genetic origin; therefore, a thorough investigation into genetic mutations should be carried. In addition, further collaborative studies are required to verify these results.

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“…recurrence. Some studies have shown improved survival rates among breast cancer patients with affected relatives compared to those without an FH [9,10], some reported poorer survival rates [11], and others did not find any survival difference between patients with or without an FH [12,13]. Most of these studies are case-control studies with relatively small numbers of patients with no long-term follow-up.…”

Section: Introductionmentioning

confidence: 99%

Long-term effects of first degree family history of breast cancer in young women: Recurrences and bilateral breast cancer

et al. 2015

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Background. The aim of this study is to analyze the impact of first degree relative (FDR) of young breast cancer patients. Methods. Data were used from our prospective population-based cohort study which started in 1983. The family history (FH) was registered with regard to FDR: the presence or absence of invasive breast cancer in none vs. one or more FDRs at any age. Results. A total of 1109 women, 50 years with 1128 breast conserving treatments was seen. The incidence of FDR was 17.0% for one FDR and 3.2% 2 FDR. The three groups, none, 1 or 2 FDR, were comparable. The local failure rate is comparable for all three groups. Women with a positive FH and metachronous bilateral breast cancer (MBBC) showed a lower local failure (HR 0.2; 95% CI 0.05-0.8). A positive FH was an independent predictor for a better disease-specific survival (HR 0.6; 95% CI 0.4-0.9). Conclusion. A positive FH, based on FDR implies a better prognosis in relation to survival for young women treated with BCT. In contrast to no FH for FDR, MBBC in women with a positive FH was not associated with an increased risk of local recurrence.

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Women age ≤ 35 years with primary breast carcinoma

Cited by 80 publications

References 24 publications

Impact of familial risk factors on management and survival of early-onset breast cancer: a population-based study

Impact of familial risk factors on management and survival of early-onset breast cancer: a population-based study

Breast cancer cases of female patients under 35ï¿½years of age in Togo: A series of 158ï¿½cases

Long-term effects of first degree family history of breast cancer in young women: Recurrences and bilateral breast cancer

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